Article
Cell Biology
Georgia Margioula-Siarkou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Kosmas Margaritis, Eleftherios Vavoulidis, Giuseppe Gullo, Maria Alexandratou, Konstantinos Dinas, Alexandros Sotiriadis, Georgios Mavromatidis
Summary: Preeclampsia, a leading cause of maternal and fetal morbidity and mortality, involves dysfunction of the placenta leading to imbalance of angiogenic and anti-angiogenic factors. Endoglin and soluble endoglin play significant roles in the pathophysiology of preeclampsia by interfering with signaling pathways that regulate angiogenesis and endothelial function. Further research is needed to explore the potential prognostic, diagnostic, and therapeutic implications of these molecules in clinical management of preeclampsia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Haiyan Chu, Anastasia Sacharidou, An Nguyen, Chun Li, Ken L. Chambliss, Jane E. Salmon, Yu-Min Shen, Julie Lo, Gustavo W. Leone, Joachim Herz, David Y. Hui, Denise K. Marciano, Vikki M. Abrahams, Bryony Natale, Alina P. Montalbano, Xue Xiao, Lin Xu, David R. Natale, Philip W. Shaul, Chieko Mineo
Summary: In this study, it was found that antiphospholipid antibodies (aPL) can induce preeclampsia by influencing placental trophoblast function and endangering the fetus. The results suggest that aPL affect preeclampsia by altering gene expression related to preeclampsia through the regulation of PP2A protein phosphatase activity. Overall, the findings indicate that the impact of aPL on trophoblast cells is crucial for the development of preeclampsia, involving modulation of various signaling pathways.
CIRCULATION RESEARCH
(2021)
Article
Developmental Biology
Fiona Brownfoot, Natalie Binder, Roxanne Hastie, Alesia Harper, Sally Beard, Laura Tuohey, Emerson Keenan, Stephen Tong, Natalie Hannan
Summary: The study found that nicotinamide (vitamin B3) did not show an effect on reducing markers of preeclampsia in primary human placental tissues and vascular cells.
Article
Cell Biology
Melanie Young, Ming Tang, Huika Li, Derek J. Richard, Donald S. A. McLeod, Michael C. d'Emden, Kerry Richard
Summary: Preeclampsia is a life-threatening condition caused by poor placentation during pregnancy. The study suggests that transthyretin, a thyroid hormone binding protein, binds to soluble endoglin (sEng) and enhances its uptake by hepatocytes. This finding may lead to potential treatment options for reducing sEng-induced vascular dysfunction.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Ayae Ozeki, Yuka Oogaki, Yuka Henmi, Tadayoshi Karasawa, Masafumi Takahashi, Hironori Takahashi, Akihide Ohkuchi, Koumei Shirasuna
Summary: This study found that S100A9 is associated with the pathogenesis of hypertensive disorders of pregnancy and can activate the NLRP3 inflammasome. Animal experiments also confirmed that injection of S100A9 can cause hypertension and neutrophil accumulation in pregnant mice.
JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Francesca Gaccioli, Ulla Sovio, Sungsam Gong, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to investigate the relationship between protein levels of sFLT1 and PlGF in maternal serum and placental tissue lysates. The findings showed that the sFLT1:PlGF ratio is increased in both preeclampsia and FGR, but in preeclampsia, it is primarily driven by increased placental sFLT1 levels, while in FGR, it is primarily driven by decreased placental PlGF levels.
Article
Physiology
Shunping Gui, Shengping Zhou, Min Liu, Yanping Zhang, Linbo Gao, Tao Wang, Rong Zhou
Summary: In patients with severe preeclampsia (sPE), the upregulation of soluble Axl (sAxl) in maternal plasma is positively correlated with elevated levels of sFlt-1 and negatively correlated with placental NO synthase (eNOS). Elevated sAxl levels suppress proliferation and tube formation of endothelial cells, and promote cytotoxicity. The study also demonstrates that sAxl plays a role in systemic vascular injury through the regulation of key molecules of angiogenesis, contributing to the development of sPE.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Biochemistry & Molecular Biology
Anna Maria Nuzzo, Laura Moretti, Paolo Mele, Tullia Todros, Carola Eva, Alessandro Rolfo
Summary: The conditioned media derived from human placenta-derived mesenchymal stromal cells (hPDMSCs) has shown pro-angiogenic and anti-inflammatory effects on a mouse model of preeclampsia, a severe pregnancy-related syndrome characterized by hypertension, proteinuria, inflammation, and fetal growth restriction. It was found that the hPDMSCs-derived conditioned media could reverse the preeclampsia-like features, including reducing maternal blood pressure, proteinuria, and levels of inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Matej Vicen, Ivone Cristina Igreja Sa, Katarina Tripska, Barbora Vitverova, Iveta Najmanova, Samira Eissazadeh, Stanislav Micuda, Petr Nachtigal
Summary: Membrane endoglin (Eng) and soluble endoglin (sEng) play important roles in metabolic syndrome-related disorders, including endothelial dysfunction, arterial hypertension, hyperglycemia, and diabetes. Reduced Eng expression is a hallmark of chronic pathologies related to metabolic syndrome, while sEng is considered a biomarker of preeclampsia.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Article
Biochemistry & Molecular Biology
Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Liang
Summary: This study confirmed the protective effects of paeoniflorin against preeclampsia-related endothelial damage by upregulating VEGFA to alleviate the injury caused by overexpression of sFlt-1 and sEng.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Mingyu Hu, Ji Li, Philip N. Baker, Chao Tong
Summary: Preeclampsia is a major threat to the health of mothers and newborns worldwide, primarily due to placental metabolic abnormalities leading to placental dysfunction.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Biochemistry & Molecular Biology
Margarita L. Martinez-Fierro, Idalia Garza-Veloz, Maria Eugenia Castaneda-Lopez, Dorothy Wasike, Claudia Castruita-De la Rosa, Iram Pablo Rodriguez-Sanchez, Ivan Delgado-Enciso, Jose Flores-Mendoza
Summary: In this study, the administration of FGF2 in a rat model of preeclampsia reduced proteinuria and elevated blood pressure, as well as the expression of genes involved in angiogenesis, apoptosis, and oxidative stress. These results provide valuable insights into the molecular targets and pathogenesis of preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Cristina Egido-Turrion, Elisa Rossi, Claudia Ollauri-Ibanez, Maria L. Perez-Garcia, Maria A. Sevilla, Jose Maria Bastida, Jose Ramon Gonzalez-Porras, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder characterized by blood vessel abnormalities and recurrent bleeding. This study investigated the mechanisms of impaired hemostasis in HHT mouse models and found deficiencies in platelet-endothelium interactions and overactivation of the fibrinolysis system. These findings offer new therapeutic approaches for HHT patients' epistaxis.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Francisco S. Lozano Sanchez, Jose A. Carnicero Martinez, Lucia Mendez-Garcia, M. Begona Garcia-Cenador, Miguel Pericacho
Summary: This study aimed to investigate the expression of angiogenesis-related molecules, including endoglin, in patients with varicose veins. The results showed that patients with recurrent varicose veins had higher expression of endoglin and other markers in the proximal venous wall compared to those with primary varicose veins. The presence of endoglin in the blood did not appear to have a significant role in recurrent varicose veins.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Josune Garcia-Sanmartin, Judit Narro-Iniguez, Alicia Rodriguez-Barbero, Alfredo Martinez
Summary: Hereditary hemorrhagic telangiectasia (HHT) is a rare disease characterized by vascular malformations and profuse bleeding. Recent research has found that HHT patients have higher levels of adrenomedullin (AM) in their blood. However, a study using mutant mice showed that the mutations responsible for HHT did not consistently affect the expression of AM. Some organs had no changes in AM levels, while others had lower or higher expression. These findings suggest that the genes and molecules related to HHT may have yet-to-be-investigated functions.
Article
Biochemistry & Molecular Biology
Pilar Puerto-Camacho, Juan Diaz-Martin, Joaquin Olmedo-Pelayo, Alfonso Bolado-Carrancio, Carmen Salguero-Aranda, Carmen Jordan-Perez, Marina Esteban-Medina, Inmaculada Alamo-Alvarez, Daniel Delgado-Bellido, Laura Lobo-Selma, Joaquin Dopazo, Ana Sastre, Javier Alonso, Thomas G. P. Gruenewald, Carmelo Bernabeu, Adam Byron, Valerie G. Brunton, Ana Teresa Amaral, Enrique De Alava
Summary: This study found that the expression of endoglin (ENG) and matrix metalloproteinase 14 (MMP14) is significantly associated with poor prognosis in Ewing sarcoma (ES) patients. Further experiments demonstrated the key role of ENG and MMP14 in cell mechanotransduction and their impact on migration and adhesion in ES cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Arturo Ibanez-Fonseca, Ana Rico, Silvia Preciado, Fernando Gonzalez-Perez, Sandra Muntion, Jesus Garcia-Brinon, Maria-Carmen Garcia-Macias, Jose Carlos Rodriguez-Cabello, Miguel Pericacho, Matilde Alonso, Fermin Sanchez-Guijo
Summary: Combination of an elastin-like recombinamer (ELR)-based hydrogel with mesenchymal stromal cells (MSCs) shows potential in improving tissue reperfusion and blood vessel density in a murine hindlimb ischemia model, suggesting a promising approach for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Katarina Tripska, Ivone Cristina Igreja Sa, Martina Vasinova, Matej Vicen, Radim Havelek, Samira Eissazadeh, Zuzana Svobodova, Barbora Vitverova, Charles Theuer, Carmelo Bernabeu, Petr Nachtigal
Summary: This study found that blocking the endoglin receptor using TRC105 can counteract endothelial dysfunction induced by high cholesterol and high glucose, suggesting that endoglin may be a potential therapeutic target for disorders associated with elevated cholesterol and glucose levels.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ivone Cristina Igreja Sa, Katarina Tripska, Fatemeh Alaei Faradonbeh, Milos Hroch, Hana Lastuvkova, Jolana Schreiberova, Marian Kacerovsky, Miguel Pericacho, Petr Nachtigal, Stanislav Micuda
Summary: Labetalol exacerbates the accumulation of bile acids (BA) in estrogen-induced cholestasis and soluble endoglin (sEng) aggravates this retention. Increased sEng levels might explain the coincidence of intrahepatic cholestasis of pregnancy (ICP) with preeclampsia. Monitoring of BA in pregnant women with preeclampsia and labetalol therapy is recommended.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Hematology
Carmelo Bernabeu
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Parasitology
Maria del Pilar Perez Rodriguez, Claudia Alarcon-Torrecillas, Miguel Pericacho, Ivan Rodriguez-Escolar, Elena Carreton, Rodrigo Morchon
Summary: This study analyzed the interaction between the somatic antigen of adult D. repens worms and the angiogenic mechanism, cell proliferation and migration, and formation of pseudo-capillaries. The results showed that the somatic antigen of adult D. repens worms synergistically enhanced the expression of VEGF-A, VEGFR-2 and mEnd, promoted cell proliferation and migration, and increased the formation of pseudo-capillaries.
PARASITES & VECTORS
(2023)
Article
Hematology
Elisa Rossi, Miguel Pericacho, Alexandre Kauskot, Luis Gamella-Pozuelo, Etienne Reboul, Alexandre Leuci, Cristina Egido-Turrion, Divina El Hamaoui, Aurore Marchelli, Francisco J. Fernandez, Isabelle Margaill, Cristina Vega, Pascale Gaussem, Samuela Pasquali, David M. Smadja, Christilla Bachelot-Loza, Carmelo Bernabeu
Summary: The results of this study demonstrate that sEng interferes with thrombus formation and stabilization by binding to platelet αIIbβ3, suggesting its involvement in primary hemostasis control.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Hematology
Elisa Rossi, Carmelo Bernabeu
Summary: This study suggests that membrane-bound endoglin and circulating endoglin play important roles in vascular homeostasis and hemostasis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)