Strategies in regenerative medicine for intervertebral disc repair using mesenchymal stem cells and bioscaffolds

Modulation of the gene expression of annulus fibrosus-derived stem cells using poly(ether carbonate urethane)urea scaffolds of tunable elasticity

(2016) Caihong Zhu et al.   Acta Biomaterialia

Thermally triggered injectable hydrogel, which induces mesenchymal stem cell differentiation to nucleus pulposus cells: Potential for regeneration of the intervertebral disc

(2016) A.A. Thorpe et al.   Acta Biomaterialia

Transplantation of CXCR4 Overexpressed Mesenchymal Stem Cells Augments Regeneration in Degenerated Intervertebral Discs

(2016) Ji-Nan Wei et al.   DNA AND CELL BIOLOGY

Tumor Necrosis Factor-stimulated Gene 6 (TSG-6)-mediated Interactions with the Inter-α-inhibitor Heavy Chain 5 Facilitate Tumor Growth Factor β1 (TGFβ1)-dependent Fibroblast to Myofibroblast Differentiation

(2016) John Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The development and characterization of SDF1α-elastin-like-peptide nanoparticles for wound healing

(2016) Agnes Yeboah et al.   JOURNAL OF CONTROLLED RELEASE

Tissue adhesives for meniscus tear repair: an overview of current advances and prospects for future clinical solutions

(2016) A. I. Bochyńska et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

A Tailor-Made Synthetic Polymer for Cell Encapsulation: Design Rationale, Synthesis, Chemical-Physics and Biological Characterizations

(2016) Irini Gerges et al.   MACROMOLECULAR BIOSCIENCE

Characterization of slow-gelling alginate hydrogels for intervertebral disc tissue-engineering applications

(2016) Emily A. Growney Kalaf et al.   Materials Science & Engineering C-Materials for Biological Applications

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Glycosaminoglycan Chemical Exchange Saturation Transfer of Lumbar Intervertebral Discs in Healthy Volunteers

(2016) Christoph Schleich et al.   SPINE

Bone Marrow Stem Cells in Response to Intervertebral Disc-Like Matrix Acidity and Oxygen Concentration

(2016) Syeda M. Naqvi et al.   SPINE

Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort

(2016) Florence P.S. Mok et al.   Spine Journal

Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification

(2016) Rik Osinga et al.   Stem Cells Translational Medicine

Novel Immortal Cell Lines Support Cellular Heterogeneity in the Human Annulus Fibrosus

(2016) Guus G. H. van den Akker et al.   PLoS One

BMP7-Based Functionalized Self-Assembling Peptides for Nucleus Pulposus Tissue Engineering

(2015) Hui Tao et al.   ACS Applied Materials & Interfaces

A radiopaque electrospun scaffold for engineering fibrous musculoskeletal tissues: Scaffold characterization and in vivo applications

(2015) John T. Martin et al.   Acta Biomaterialia

Effect of the mixture of bone marrow mesenchymal stromal cells and annulus fibrosus cells in repairing the degenerative discs of rabbits

(2015) Y.H. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Adipose-Derived Stromal Cells Protect Intervertebral Disc Cells in Compression: Implications for Stem Cell Regenerative Disc Therapy

(2015) Zhen Sun et al.   International Journal of Biological Sciences

3D-Printed ABS and PLA Scaffolds for Cartilage and Nucleus Pulposus Tissue Regeneration

(2015) Derek Rosenzweig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Study design: in vitro and in vivo assessment of bone morphogenic protein 2 combined with platelet-rich plasma on treatment of disc degeneration

(2015) Yang Hou et al.   INTERNATIONAL ORTHOPAEDICS

Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments

(2015) Syeda M. Naqvi et al.   JOURNAL OF ANATOMY

Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts

(2015) Aya Nagaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosaminoglycan chemical exchange saturation transfer of lumbar intervertebral discs in patients with spondyloarthritis

(2015) Christoph Schleich et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

(2015) Makarand V. Risbud et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Age- and degeneration-related variations in cell density and glycosaminoglycan content in the human cervical intervertebral disc and its endplates

(2015) Krzysztof A. Tomaszewski et al.   POLISH JOURNAL OF PATHOLOGY

Differentiation of Human Ligamentum Flavum Stem Cells Toward Nucleus Pulposus-Like Cells Induced by Coculture System and Hypoxia

(2015) Xiao-Bo Han et al.   SPINE

Autophagy in the Degenerating Human Intervertebral Disc

(2015) Helen E. Gruber et al.   SPINE

Transplantation of human Wharton’s jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration

(2015) Jongchan Ahn et al.   Stem Cell Research & Therapy

Nucleus Pulposus Mesenchymal Stem Cells in Acidic Conditions Mimicking Degenerative Intervertebral Discs Give Better Performance than Adipose Tissue-Derived Mesenchymal Stem Cells

(2015) Bin Han et al.   CELLS TISSUES ORGANS

Three-dimensional hypoxic culture of human mesenchymal stem cells encapsulated in a photocurable, biodegradable polymer hydrogel: A potential injectable cellular product for nucleus pulposus regeneration

(2014) Deepak Kumar et al.   Acta Biomaterialia

Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: Effect of TGF-β3 supplementation and oxygen culture conditions

(2014) Olivier Guillaume et al.   Acta Biomaterialia

Duration of TGF-β3 Exposure Impacts the Chondrogenic Maturation of Human MSCs in Photocrosslinked Carboxymethylcellulose Hydrogels

(2014) Michelle S. Gupta et al.   ANNALS OF BIOMEDICAL ENGINEERING

The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs

(2014) Catarina Leite Pereira et al.   BIOMATERIALS

Short-term follow-up of disc cell therapy in a porcine nucleotomy model with an albumin–hyaluronan hydrogel: in vivo and in vitro results of metabolic disc cell activity and implant distribution

(2014) G. W. Omlor et al.   EUROPEAN SPINE JOURNAL

Axial T1ρ MRI as a diagnostic imaging modality to quantify proteoglycan concentration in degenerative disc disease

(2014) Kyle R. Mulligan et al.   EUROPEAN SPINE JOURNAL

Enhancing cell migration in shape-memory alginate–collagen composite scaffolds: In vitro and ex vivo assessment for intervertebral disc repair

(2014) Olivier Guillaume et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Effect of demineralized bone particle/poly(lactic-co-glycolic acid) scaffolds on the attachment and proliferation of mesenchymal stem cells

(2014) Kap-Soo Han et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Preparation and Biomedical Applications of Chitin and Chitosan Nanofibers

(2014) Kazuo Azuma et al.   Journal of Biomedical Nanotechnology

Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R1ρdispersion and −OH chemical exchange saturation transfer (RROC)

(2014) Qi Liu et al.   MAGNETIC RESONANCE IN MEDICINE

Silk fibroin porous scaffolds for nucleus pulposus tissue engineering

(2014) Chao Zeng et al.   Materials Science & Engineering C-Materials for Biological Applications

Intervertebral disc regeneration: do nutrients lead the way?

(2014) Yong-Can Huang et al.   Nature Reviews Rheumatology

Specific Sizes of Hyaluronan Oligosaccharides Stimulate Fibroblast Migration and Excisional Wound Repair

(2014) Cornelia Tolg et al.   PLoS One

Sox9 Gene Transfer Enhanced Regenerative Effect of Bone Marrow Mesenchymal Stem Cells on the Degenerated Intervertebral Disc in a Rabbit Model

(2014) Wei Sun et al.   PLoS One

Effects of Transplantation of hTIMP-1–Expressing Bone Marrow Mesenchymal Stem Cells on the Extracellular Matrix of Degenerative Intervertebral Discs in an In Vivo Rabbit Model

(2014) Zhou Yi et al.   SPINE

Differentiation of Menstrual Blood–Derived Stem Cells Toward Nucleus Pulposus-Like Cells in a Coculture System With Nucleus Pulposus Cells

(2014) Xuqi Hu et al.   SPINE

Intervertebral disc and stem cells cocultured in biomimetic extracellular matrix stimulated by cyclic compression in perfusion bioreactor

(2014) Tsung-Lin Tsai et al.   Spine Journal

Effects of hypoxia on differentiation from human placenta-derived mesenchymal stem cells to nucleus pulposus-like cells

(2014) Li Ni et al.   Spine Journal

In Vitro Characterization of a Stem-Cell-Seeded Triple-Interpenetrating-Network Hydrogel for Functional Regeneration of the Nucleus Pulposus

(2014) Lachlan J. Smith et al.   TISSUE ENGINEERING PART A

Inner and Outer Annulus Fibrosus Cells Exhibit Differentiated Phenotypes and Yield Changes in Extracellular Matrix Protein Composition In Vitro on a Polycarbonate Urethane Scaffold

(2014) Jonathan Iu et al.   TISSUE ENGINEERING PART A

Biological Evaluation of Human Degenerated Nucleus Pulposus Cells in Functionalized Self-Assembling Peptide Nanofiber Hydrogel Scaffold

(2014) Hui Tao et al.   TISSUE ENGINEERING PART A

Novel immortal human cell lines reveal subpopulations in the nucleus pulposus

(2014) Guus GH van den Akker et al.   ARTHRITIS RESEARCH & THERAPY

Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration

(2013) Aubrey T. Francisco et al.   Acta Biomaterialia

Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: Biomimetic glycosaminoglycan analogues

(2013) S.S. Sivan et al.   Acta Biomaterialia

Differentiation of GFP-Bcl-2-engineered mesenchymal stem cells towards a nucleus pulposus-like phenotype under hypoxia in vitro

(2013) Zhong Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of bound versus soluble pentosan polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc regeneration

(2013) Jessica E. Frith et al.   BIOMATERIALS

Influence of Hypoxia in the Intervertebral Disc on the Biological Behaviors of Rat Adipose- and Nucleus Pulposus-Derived Mesenchymal Stem Cells

(2013) Hao Li et al.   CELLS TISSUES ORGANS

Cell sources for nucleus pulposus regeneration

(2013) Nevenka Kregar Velikonja et al.   EUROPEAN SPINE JOURNAL

Mechanical stress-induced apoptosis of nucleus pulposus cells: an in vitro and in vivo rat model

(2013) Yi-Jie Kuo et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced-field-of-view turbo spin echo at 3.0 T

(2013) Qi Liu et al.   NMR IN BIOMEDICINE

Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells—a potential novel treatment for intervertebral disc degeneration

(2013) Qihai Liu et al.   Spine Journal

Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells

(2013) Marianna Peroglio et al.   Spine Journal

Modulation of annulus fibrosus cell alignment and function on oriented nanofibrous polyurethane scaffolds under tension

(2013) Kathleen G. Turner et al.   Spine Journal

Human umbilical cord mesenchymal stromal cells in regenerative medicine

(2013) Michael S Detamore   Stem Cell Research & Therapy

Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system

(2013) Brian H Chon et al.   Stem Cell Research & Therapy

Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System

(2013) Christian Bucher et al.   Stem Cells International

Novel Cartilage-derived Biomimetic Scaffold for Human Nucleus Pulposus Regeneration: a Promising Therapeutic Strategy for Symptomatic Degenerative Disc Diseases

(2013) Qiang Yang et al.   Orthopaedic Surgery

Oriented lamellar silk fibrous scaffolds to drive cartilage matrix orientation: Towards annulus fibrosus tissue engineering

(2012) Maumita Bhattacharjee et al.   Acta Biomaterialia

Dual delivery for stem cell differentiation using dexamethasone and bFGF in/on polymeric microspheres as a cell carrier for nucleus pulposus regeneration

(2012) C. Z. Liang et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Anabolic Effects of Peniel 2000, a Peptide That Regulates TGF-β1 Signaling on Intervertebral Disc Degeneration

(2012) Young-Joon Kwon et al.   SPINE

Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells

(2012) Marius Strioga et al.   STEM CELLS AND DEVELOPMENT

The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells

(2012) John Antoniou et al.   ARTHRITIS RESEARCH & THERAPY

Effects of hypoxias and scaffold architecture on rabbit mesenchymal stem cell differentiation towards a nucleus pulposus-like phenotype

(2011) Ganjun Feng et al.   BIOMATERIALS

Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells

(2011) Alessandro Bertolo et al.   EUROPEAN SPINE JOURNAL

A Viscoelastic Chitosan-Modified Three-Dimensional Porous Poly(L-Lactide-co-ε-Caprolactone) Scaffold for Cartilage Tissue Engineering

(2011) Chao Li et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Functionalized self-assembling peptide nanofiber hydrogel as a scaffold for rabbit nucleus pulposus cells

(2011) Baichuan Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Incorporation of biomimetic matrix molecules in PEG hydrogels enhances matrix deposition and reduces load-induced loss of chondrocyte-secreted matrix

(2011) Justine J. Roberts et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell sheets and silk scaffolds for annulus fibrosus regeneration

(2011) Eugene Yong-Shun See et al.   Journal of Tissue Engineering and Regenerative Medicine

Regeneration of the Intervertebral Disc With Nucleus Pulposus Cell-Seeded Collagen II/Hyaluronan/Chondroitin-6-Sulfate Tri-Copolymer Constructs in a Rabbit Disc Degeneration Model

(2011) Bo Huang et al.   SPINE

Transforming Growth Factor-Beta 3 Stimulates Cartilage Matrix Elaboration by Human Marrow-Derived Stromal Cells Encapsulated in Photocrosslinked Carboxymethylcellulose Hydrogels: Potential for Nucleus Pulposus Replacement

(2011) Michelle S. Gupta et al.   TISSUE ENGINEERING PART A

Silk-Fibrin/Hyaluronic Acid Composite Gels for Nucleus Pulposus Tissue Regeneration

(2011) Sang-Hyug Park et al.   TISSUE ENGINEERING PART A

Intervertebral Disk Tissue Engineering Using Biphasic Silk Composite Scaffolds

(2011) Sang-Hyug Park et al.   TISSUE ENGINEERING PART A

Development of Gellan Gum-Based Microparticles/Hydrogel Matrices for Application in the Intervertebral Disc Regeneration

(2011) Diana Ribeiro Pereira et al.   TISSUE ENGINEERING PART C-METHODS

Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study

(2011) Lluis Orozco et al.   TRANSPLANTATION

The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration

(2011) Fackson Mwale et al.   ARTHRITIS RESEARCH & THERAPY

The Effect of Sustained Compression on Oxygen Metabolic Transport in the Intervertebral Disc Decreases with Degenerative Changes

(2011) Andrea Malandrino et al.   PLoS Computational Biology

The response of annulus fibrosus cell to fibronectin-coated nanofibrous polyurethane-anionic dihydroxyoligomer scaffolds

(2010) Menat Attia et al.   BIOMATERIALS

Matricryptins derived from collagens and proteoglycans

(2010) Sylvie Ricard-Blum   Frontiers in Bioscience-Landmark

Novel tissue-derived biomimetic scaffold for regenerating the human nucleus pulposus

(2010) Jeremy J. Mercuri et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Synthesis and characterization of injectable composites of poly[D,L-lactide-co-(ε-caprolactone)] reinforced with β-TCP and CaCO3 for intervertebral disk augmentation

(2010) Alejandro López et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Electrospun Nanofibrous Polycaprolactone Scaffolds for Tissue Engineering of Annulus Fibrosus

(2010) Laura Koepsell et al.   MACROMOLECULAR BIOSCIENCE

Injectable Biodegradable Poly(ethylene glycol)/RGD Peptide Hybrid Hydrogels for in vitro Chondrogenesis of Human Mesenchymal Stem Cells

(2010) Shao Qiong Liu et al.   MACROMOLECULAR RAPID COMMUNICATIONS

A Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc Degeneration

(2010) Meredith L. Schollum et al.   SPINE

A Novel Thiol-Modified Hyaluronan and Elastin-Like Polypetide Composite Material for Tissue Engineering of the Nucleus Pulposus of the Intervertebral Disc

(2010) Isaac L. Moss et al.   SPINE

Age-Related Variation in Cell Density of Human Lumbar Intervertebral Disc

(2010) Thomas Liebscher et al.   SPINE

Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-β1 decrease rabbit intervertebral disc degeneration

(2010) Huilin Yang et al.   Spine Journal

Effect of Synthetic Link N Peptide on the Expression of Type I and Type II Collagens in Human Intervertebral Disc Cells

(2010) Alain Petit et al.   TISSUE ENGINEERING PART A

MSC response to pH levels found in degenerating intervertebral discs

(2009) Karin Wuertz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Frog glue enhances rotator cuff repair in a laboratory cadaveric model

(2009) Neal L. Millar et al.   JOURNAL OF SHOULDER AND ELBOW SURGERY

The Role of Hypoxia in Stem Cell Differentiation and Therapeutics

(2009) Hamid Abdollahi et al.   JOURNAL OF SURGICAL RESEARCH

Behavior of Mesenchymal Stem Cells in the Chemical Microenvironment of the Intervertebral Disc

(2009) Karin Wuertz et al.   SPINE

Coculture of Bone Marrow Mesenchymal Stem Cells and Nucleus Pulposus Cells Modulate Gene Expression Profile Without Cell Fusion

(2009) Gianluca Vadalà et al.   SPINE

Differential Phenotype of Intervertebral Disc Cells

(2009) Daisuke Sakai et al.   SPINE

Coculture of Synovium-Derived Stem Cells and Nucleus Pulposus Cells in Serum-Free Defined Medium With Supplementation of Transforming Growth Factor-β1

(2009) Song Chen et al.   SPINE

Intervertebral Disc Repair Using Adipose Tissue-Derived Stem and Regenerative Cells

(2009) Timothy Ganey et al.   SPINE

Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model

(2009) Wayne Murrell et al.   Spine Journal

Chondrogenesis of Adult Stem Cells from Adipose Tissue and Bone Marrow: Induction by Growth Factors and Cartilage-Derived Matrix

(2009) Brian O. Diekman et al.   TISSUE ENGINEERING PART A

All MSCs Are Pericytes?

(2008) Arnold I. Caplan   Cell Stem Cell

Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies

(2008) James Melrose et al.   EUROPEAN SPINE JOURNAL

Characterization of photocrosslinked alginate hydrogels for nucleus pulposus cell encapsulation

(2008) Alice I. Chou et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future

(2008) R. J. W. Hoogendoorn et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Highly Open Porous Biodegradable Microcarriers: In Vitro Cultivation of Chondrocytes for Injectable Delivery

(2008) Hyun Jung Chung et al.   TISSUE ENGINEERING PART A

Cell viability, proliferation and extracellular matrix production of human annulus fibrosus cells cultured within PDLLA/Bioglass® composite foam scaffolds in vitro

(2007) Wilda Helen et al.   Acta Biomaterialia