期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 3, 页码 391-399出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000352
关键词
biological application of polymers; fibers; fluorescence; polycaprolactone; tissue engineering
资金
- University of South Dakota
- South Dakota School of Mines and Technology
- South Dakota Board of Regents [SDBOR/USD 2011-10-07]
The annulus fibrosus comprises concentric lamellae that can be damaged due to intervertebral disc degeneration; to provide permanent repair of these acquired structural defects, one solution is to fabricate scaffolds that are designed to support the growth of annulus fibrosus cells. In this study, electrospun nanofibrous scaffolds of polycaprolactone are fabricated in random, aligned, and round-end configurations. Primary porcine annulus fibrosus cells are grown on the scaffolds and evaluated for attachment, proliferation, and production of extracellular matrix. The scaffold consisting of round-end nanofibers substantially outperforms the random and aligned scaffolds on cell adhesion; additionally, the scaffold with aligned nanofibers strongly affects the orientation of cells.
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