A guide to the 3D structure of the ryanodine receptor type 1 by cryoEM

Ultrastructural Analysis of Self-Associated RyR2s

(2016) Vanessa Cabra et al.   BIOPHYSICAL JOURNAL

Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1

(2016) Risheng Wei et al.   CELL RESEARCH

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

(2016) Xiao-Chen Bai et al.   CELL RESEARCH

A Primer to Single-Particle Cryo-Electron Microscopy

(2015) Yifan Cheng et al.   CELL

Nanoscale analysis of ryanodine receptor clusters in dyadic couplings of rat cardiac myocytes

(2015) Yufeng Hou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure of the voltage-gated calcium channel Cav1.1 complex

(2015) J. Wu et al.   SCIENCE

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

(2015) Zhiguang Yuchi et al.   Nature Communications

Single-particle cryo-electron microscopy of macromolecular complexes

(2015) Georgios Skiniotis et al.   Microscopy

The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury

(2014) Christopher M. Lewarchik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Myoplasmic resting Ca2+regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor

(2014) Yanyi Chen et al.   BIOCHEMICAL JOURNAL

Two Regions of the Ryanodine Receptor Calcium Channel Are Involved in Ca2+-Dependent Inactivation

(2014) Angela C. Gomez et al.   BIOCHEMISTRY

Superresolution Modeling of Calcium Release in the Heart

(2014) Mark A. Walker et al.   BIOPHYSICAL JOURNAL

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

Architecture and conformational switch mechanism of the ryanodine receptor

(2014) Rouslan G. Efremov et al.   NATURE

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain

(2014) Kelvin Lau et al.   Nature Communications

Control of Sarcoplasmic Reticulum Ca2+ Release by Stochastic RyR Gating within a 3D Model of the Cardiac Dyad and Importance of Induction Decay for CICR Termination

(2013) M.B. Cannell et al.   BIOPHYSICAL JOURNAL

Single-particle Cryo-EM of calcium release channels: structural validation

(2013) Steven J Ludtke et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Skeletal muscle excitation–contraction coupling: Who are the dancing partners?

(2013) Robyn T. Rebbeck et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structural Determinants of Skeletal Muscle Ryanodine Receptor Gating

(2013) Srinivas Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107

(2013) Yingwu Mei et al.   PLoS One

Conformational Dynamics inside Amino-Terminal Disease Hotspot of Ryanodine Receptor

(2013) Xiaowei Zhong et al.   STRUCTURE

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

(2013) Lynn Kimlicka et al.   Nature Communications

An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity

(2012) Kyoko Takano et al.   HUMAN MOLECULAR GENETICS

Fluorescence Resonance Energy Transfer (FRET) Indicates That Association with the Type I Ryanodine Receptor (RyR1) Causes Reorientation of Multiple Cytoplasmic Domains of the Dihydropyridine Receptor (DHPR) α1SSubunit

(2012) Alexander Polster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-Dimensional Localization of the α and β Subunits and of the II-III Loop in the Skeletal Muscle L-type Ca2+Channel

(2012) John Szpyt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin-binding Locations on the Skeletal and Cardiac Ryanodine Receptors

(2012) Xiaojun Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triadin/Junctin Double Null Mouse Reveals a Differential Role for Triadin and Junctin in Anchoring CASQ to the jSR and Regulating Ca2+ Homeostasis

(2012) Simona Boncompagni et al.   PLoS One

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

(2012) Akshay A. D'Cruz et al.   PROTEIN SCIENCE

Disease Mutations in the Ryanodine Receptor Central Region: Crystal Structures of a Phosphorylation Hot Spot Domain

(2012) Zhiguang Yuchi et al.   STRUCTURE

3D Mapping of the SPRY2 Domain of Ryanodine Receptor 1 by Single-Particle Cryo-EM

(2011) Alex Perálvarez-Marín et al.   PLoS One

Electronic detectors for electron microscopy

(2011) A. R. Faruqi et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Ryanodine receptors

(2011) E Michelle Capes et al.   Skeletal Muscle

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

(2010) Ching-Chieh Tung et al.   NATURE

Ryanodine receptor assembly: A novel systems biology approach to 3D mapping

(2010) Dong Woo Song et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Armadillo-repeat protein functions: questions for little creatures

(2010) Rita Tewari et al.   TRENDS IN CELL BIOLOGY

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin

(2009) Lan Wei et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CLIC2-RyR1 Interaction and Structural Characterization by Cryo-electron Microscopy

(2009) Xing Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

SPRY Domain-Containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding

(2009) Zhihe Kuang et al.   JOURNAL OF MOLECULAR BIOLOGY

Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

(2009) David Baddeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel

(2009) R. L. Cornea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-particle reconstruction of biological macromolecules in electron microscopy – 30 years

(2009) Joachim Frank   QUARTERLY REVIEWS OF BIOPHYSICS

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

(2009) Montserrat Samsó et al.   PLOS BIOLOGY

A dihydropyridine receptor α1s loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor

(2008) Yanfang Cui et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel

(2008) I. I. Serysheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of human chloride intracellular channel protein 2: A disulfide bond with functional implications

(2008) Wei Mi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS