Bioconjugation – using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

(2016) Scott H. Medina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optimal Synthetic Glycosylation of a Therapeutic Antibody

(2016) Thomas B. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Protein Modification through Cysteine

(2016) Smita B. Gunnoo et al.   CHEMBIOCHEM

Towards the next generation of biomedicines by site-selective conjugation

(2016) Qi-Ying Hu et al.   CHEMICAL SOCIETY REVIEWS

Half-life extended biotherapeutics

(2016) Roland E. Kontermann   EXPERT OPINION ON BIOLOGICAL THERAPY

Erratum: Corrigendum: Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

Targeting anti-apoptotic Bcl2 proteins with scyllatoxin-based BH3 domain mimetics

(2016) M. Margaret Harris et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Selective chemical labeling of proteins

(2016) Xi Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

(2016) Shayli Varasteh Moradi et al.   Chemical Science

Polymyxins facilitate entry into mammalian cells

(2016) Kristina M. Hamill et al.   Chemical Science

Boronic Acid for the Traceless Delivery of Proteins into Cells

(2015) Kristen A. Andersen et al.   ACS Chemical Biology

Synthetic strategies for polypeptides and proteins by chemical ligation

(2015) Ming Chen et al.   AMINO ACIDS

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates

(2015) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Antibody–Drug Conjugates for Tumor Targeting—Novel Conjugation Chemistries and the Promise of non-IgG Binding Proteins

(2015) Hannes Merten et al.   BIOCONJUGATE CHEMISTRY

Field Guide to Challenges and Opportunities in Antibody–Drug Conjugates for Chemists

(2015) Mallory R. Gordon et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics

(2015) Eunhee G. Kim et al.   Biomolecules & Therapeutics

Modification of daunorubicin-GnRH-III bioconjugates with oligoethylene glycol derivatives to improve solubility and bioavailability for targeted cancer chemotherapy

(2015) Rózsa Hegedüs et al.   BIOPOLYMERS

Modulating protein–protein interactions: the potential of peptides

(2015) Laura Nevola et al.   CHEMICAL COMMUNICATIONS

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

(2015) Oleksandr Koniev et al.   CHEMICAL SOCIETY REVIEWS

Peptide stapling techniques based on different macrocyclisation chemistries

(2015) Yu Heng Lau et al.   CHEMICAL SOCIETY REVIEWS

Generating Site-Specifically Modified Proteins via a Versatile and Stable Nucleophilic Carbon Ligation

(2015) Romas Kudirka et al.   CHEMISTRY & BIOLOGY

Protein–polymer conjugation—moving beyond PEGylation

(2015) Yizhi Qi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Challenges and opportunities for non-antibody scaffold drugs

(2015) Rodrigo Vazquez-Lombardi et al.   DRUG DISCOVERY TODAY

Site-Specific PEGylation of Therapeutic Proteins

(2015) Jonathan Dozier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

(2015) Jesper Lau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug delivery and release systems for targeted tumor therapy

(2015) David Böhme et al.   JOURNAL OF PEPTIDE SCIENCE

Head to Head Comparison of the Formulation and Stability of Concentrated Solutions of HESylated versus PEGylated Anakinra

(2015) Robert Liebner et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Octreotide-Mediated Tumor-Targeted Drug Delivery via a Cleavable Doxorubicin–Peptide Conjugate

(2015) Marco Lelle et al.   MOLECULAR PHARMACEUTICS

Using GlycoDelete to produce proteins lacking plant-specific N-glycan modification in seeds

(2015) Robin Piron et al.   NATURE BIOTECHNOLOGY

Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake

(2015) Abhishek Iyer et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Non-immunoglobulin scaffolds: a focus on their targets

(2015) Katja Škrlec et al.   TRENDS IN BIOTECHNOLOGY

Designing logical codon reassignment – Expanding the chemistry in biology

(2015) Anaëlle Dumas et al.   Chemical Science

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

(2014) Christopher H. Douse et al.   ACS Chemical Biology

Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability

(2014) Nicole Nischan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

(2014) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developments in the Field of Bioorthogonal Bond Forming Reactions—Past and Present Trends

(2014) Mathias King et al.   BIOCONJUGATE CHEMISTRY

Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

(2014) Penelope M. Drake et al.   BIOCONJUGATE CHEMISTRY

A GLP-1 receptor agonist conjugated to an albumin-binding domain for extended half-life

(2014) Joel Lindgren et al.   BIOPOLYMERS

Co-opting biology to deliver drugs

(2014) Parisa Yousefpour et al.   BIOTECHNOLOGY AND BIOENGINEERING

Albumin and its application in drug delivery

(2014) Darrell Sleep   Expert Opinion on Drug Delivery

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins

(2014) Leander Meuris et al.   NATURE BIOTECHNOLOGY

A survey of breakthrough therapy designations

(2014) Saurabh (Rob) Aggarwal   NATURE BIOTECHNOLOGY

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

A general approach to site-specific antibody drug conjugates

(2014) Feng Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

Structural basis of IL-23 antagonism by an Alphabody protein scaffold

(2014) Johan Desmet et al.   Nature Communications

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies

(2013) Patrizia Limonta et al.   CANCER TREATMENT REVIEWS

Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

(2013) Kurt Hoogewijs et al.   CHEMICAL COMMUNICATIONS

Site-specific fatty acid-conjugation to prolong protein half-life in vivo

(2013) Sung In Lim et al.   JOURNAL OF CONTROLLED RELEASE

Conjugates of Modified Cryptophycins and RGD-Peptides Enter Target Cells by Endocytosis

(2013) Markus Nahrwold et al.   JOURNAL OF MEDICINAL CHEMISTRY

Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

(2013) A. Orlova et al.   JOURNAL OF NUCLEAR MEDICINE

Site-Specific Antibody–Polymer Conjugates for siRNA Delivery

(2013) Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increasing the Antitumor Effect of an EpCAM-Targeting Fusion Toxin by Facile Click PEGylation

(2013) M. Simon et al.   MOLECULAR CANCER THERAPEUTICS

Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications

(2013) Sue Hyun Lee et al.   Advanced Healthcare Materials

Folate-mediated delivery of macromolecular anticancer therapeutic agents

(2012) Yingjuan Lu et al.   ADVANCED DRUG DELIVERY REVIEWS

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

(2012) Christopher A. Lipinski et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of Copper-Catalyzed Azide–Alkyne Cycloaddition for Increased in Vivo Efficacy of Interferon β-1b by Site-Specific PEGylation

(2012) Natalie W. Nairn et al.   BIOCONJUGATE CHEMISTRY

Newly Designed Modifier Prolongs the Action of Short-Lived Peptides and Proteins by Allowing Their Binding to Serum Albumin

(2012) Yoram Shechter et al.   BIOCONJUGATE CHEMISTRY

Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats

(2012) Adam R. Mezo et al.   BIOCONJUGATE CHEMISTRY

Bicyclization and Tethering to Albumin Yields Long-Acting Peptide Antagonists

(2012) Alessandro Angelini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of an Orally Active Glycosylated Endomorphin-1

(2012) Pegah Varamini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sequence Specific DNA Cross-Linking Triggered by Visible Light

(2012) Marieke Op de Beeck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Boronate-Mediated Biologic Delivery

(2012) Gregory A. Ellis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4

(2011) Marilena Manea et al.   BIOCONJUGATE CHEMISTRY

Site-specific folate conjugation to a cytotoxic protein

(2011) Bryan D. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

(2011) Michael M. Madden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links

(2011) Conor M. Haney et al.   CHEMICAL COMMUNICATIONS

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydrogen Peroxide Inducible DNA Cross-Linking Agents: Targeted Anticancer Prodrugs

(2011) Yunyan Kuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Optimized clinical performance of growth hormone with an expanded genetic code

(2011) H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

(2010) J. R. Junutula et al.   CLINICAL CANCER RESEARCH

Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications

(2010) J. Löfblom et al.   FEBS LETTERS

Folate-Targeted Therapies for Cancer

(2010) Wei Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

Adnectins: engineered target-binding protein therapeutics

(2010) D. Lipovsek   PROTEIN ENGINEERING DESIGN & SELECTION

New Strategy for the Extension of the Serum Half-Life of Antibody Fragments

(2009) Sabrina Trüssel et al.   BIOCONJUGATE CHEMISTRY

Glycosylated DOTA−α-Melanocyte-Stimulating Hormone Analogues for Melanoma Targeting: Influence of the Site of Glycosylation on in Vivo Biodistribution

(2009) Jean-Philippe Bapst et al.   BIOCONJUGATE CHEMISTRY

Safety, tolerability, pharmacodynamics and pharmacokinetics of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in healthy subjects

(2009) M. A. Bush et al.   DIABETES OBESITY & METABOLISM

Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives

(2009) Eun Ju Oh et al.   JOURNAL OF CONTROLLED RELEASE

Methoxy poly (ethylene glycol) thiosulfonate: new activated polymer derivatives for thiol-specific modification

(2009) Yong-Jiang Zhao et al.   POLYMERS FOR ADVANCED TECHNOLOGIES

Novel Chemically Modified Analogues of Neuropeptide Y for Tumor Targeting§

(2008) Denise Zwanziger et al.   BIOCONJUGATE CHEMISTRY

Poly(2-methacryloyloxyethyl phosphorylcholine) for Protein Conjugation

(2008) Andrew Lewis et al.   BIOCONJUGATE CHEMISTRY

Conjugation of ATIII-Binding Pentasaccharides to Extend the Half-Life of Proteins: Long-Acting Insulin

(2008) Martin de Kort et al.   ChemMedChem

Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery

(2008) Andreas Lehmann   EXPERT OPINION ON BIOLOGICAL THERAPY

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

(2008) Jagath R. Junutula et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

(2008) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering of a femtomolar affinity binding protein to human serum albumin

(2008) A. Jonsson et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Disulfide bridge based PEGylation of proteins

(2007) Steve Brocchini et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthesis and characterization of poly(2-ethyl 2-oxazoline)-conjugates with proteins and drugs: Suitable alternatives to PEG-conjugates?

(2007) Anna Mero et al.   JOURNAL OF CONTROLLED RELEASE