Co-opting biology to deliver drugs

Intra-Erythrocyte Infusion of Dexamethasone Reduces Neurological Symptoms in Ataxia Teleangiectasia Patients: Results of a Phase 2 Trial

(2014) Luciana Chessa et al.   Orphanet Journal of Rare Diseases

Albumin as a versatile platform for drug half-life extension

(2013) Darrell Sleep et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

nab-Paclitaxel mechanisms of action and delivery

(2013) Denise A. Yardley   JOURNAL OF CONTROLLED RELEASE

Structural basis for molecular recognition of folic acid by folate receptors

(2013) Chen Chen et al.   NATURE

Drug Delivery Using Platelet Cancer Cell Interaction

(2013) Sounik Sarkar et al.   PHARMACEUTICAL RESEARCH

Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

(2013) Matthew J. Haney et al.   PLoS One

Red Blood Cell-Encapsulated L-Asparaginase: Potential Therapy of Patients with Asparagine Synthetase Deficient Acute Myeloid Leukemia

(2013) Vaidehi Agrawal et al.   PROTEIN AND PEPTIDE LETTERS

Nanosized Multifunctional Polyplexes for Receptor-Mediated SiRNA Delivery

(2012) Christian Dohmen et al.   ACS Nano

Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats

(2012) Adam R. Mezo et al.   BIOCONJUGATE CHEMISTRY

A dual-targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas

(2012) Yan Li et al.   BIOMATERIALS

Comparison of two flow-based imaging methods to measure individual red blood cell area and volume

(2012) Giovanna Tomaiuolo et al.   CYTOMETRY PART A

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

(2012) Anders Etzerodt et al.   JOURNAL OF CONTROLLED RELEASE

Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates

(2012) Timothy Millington et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Transferrin–cisplatin specifically deliver cisplatin to HepG2 cells in vitro and enhance cisplatin cytotoxicity

(2012) Lian-Zhong Luo et al.   Journal of Proteomics

Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein

(2012) R. T. PETERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Peptibodies: A flexible alternative format to antibodies

(2012) Grant Shimamoto et al.   mAbs

Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia

(2012) C.W.G. Redman et al.   PLACENTA

Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

(2012) Christian Dohmen et al.   Molecular Therapy-Nucleic Acids

Endocytic mechanism of transferrin-conjugated nanoparticles and the effects of their size and ligand number on the efficiency of drug delivery

(2012) Takuma Tsuji et al.   Microscopy

Cell-Based Drug Delivery Devices Using Phagocytosis-Resistant Backpacks

(2011) Nishit Doshi et al.   ADVANCED MATERIALS

Biochemically altered human erythrocytes as a carrier for targeted delivery of primaquine: an In Vitro study

(2011) Fars K. Alanazi et al.   ARCHIVES OF PHARMACAL RESEARCH

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Liposome based delivery systems in pancreatic cancer treatment: From bench to bedside

(2011) Feng Yang et al.   CANCER TREATMENT REVIEWS

Cell-mediated drug delivery

(2011) Elena V Batrakova et al.   Expert Opinion on Drug Delivery

Pulmonary Administration of Interferon Beta-1a-Fc Fusion Protein in Non-Human Primates Using an Immunoglobulin Transport Pathway

(2011) Sebastien Vallee et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Engineering of erythrocyte-based drug carriers: control of protein release and bioactivity

(2011) Rongcong Luo et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Belatacept

(2011) Flavio Vincenti et al.   NATURE REVIEWS DRUG DISCOVERY

More Effective Nanomedicines through Particle Design

(2011) Jin Wang et al.   Small

Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation

(2010) S. Zaitsev et al.   BLOOD

Targeted delivery of oligomannose-coated liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancer

(2010) Makoto Matsui et al.   CANCER SCIENCE

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

(2010) Anupa R. Menjoge et al.   DRUG DISCOVERY TODAY

Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7α-APTADD to breast cancer cells

(2010) Yu Zheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

RGD modified albumin nanospheres for tumour vasculature targeting

(2010) Praveen K. Dubey et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

(2010) Stephan Kontos et al.   MOLECULAR PHARMACEUTICS

Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson’s disease

(2010) Anna M Brynskikh et al.   Nanomedicine

Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery

(2010) Sarah R MacEwan et al.   Nanomedicine

Proteomics retrenches

(2010) Peter Mitchell   NATURE BIOTECHNOLOGY

Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues

(2009) Mini Thomas et al.   Annals of the New York Academy of Sciences

CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools

(2009) P. Sathyanarayana et al.   BLOOD

Increasing the selectivity of amikacin in rat peritoneal macrophages using carrier erythrocytes

(2009) Elsa Briones et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis

(2009) C Bracewell et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

(2009) Rongbao Zhao et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Folate-mediated targeting of albumin conjugates of paclitaxel obtained through a heterogeneous phase system

(2009) Franco Dosio et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

L-Asparaginase encapsulated intact erythrocytes for treatment of acute lymphoblastic leukemia (ALL)

(2009) Young Min Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Development of novel 5-fluorouracil carrier erythrocyte with pharmacokinetics and potent antitumor activity in mice bearing malignant ascites

(2009) Guo-Ping Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS

(2009) H. Dou et al.   JOURNAL OF IMMUNOLOGY

Nanoparticle Albumin - Bound (NAB) Technology is a Promising Method for Anti-Cancer Drug Delivery

(2009) Qiang Fu et al.   Recent Patents on Anti-Cancer Drug Discovery

Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery

(2008) Monty Liong et al.   ACS Nano

Targeted drug delivery by in vivo coupling to endogenous albumin: an albumin-binding prodrug of methotrexate (MTX) is better than MTX in the treatment of murine collagen-induced arthritis

(2008) C Fiehn et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies

(2008) Hal M. Hoffman et al.   ARTHRITIS AND RHEUMATISM

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

(2008) D.R. Richardson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Design and synthesis of releasable folate–drug conjugates using a novel heterobifunctional disulfide-containing linker

(2008) Apparao Satyam   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages

(2008) W. Xia et al.   BLOOD

Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide

(2008) Steve Oh et al.   CANCER LETTERS

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

(2008) Karsten Ulbrich et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study of ACE-011 (ActRIIA-IgG1) in Postmenopausal Women*

(2008) Jon Ruckle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transferrin-conjugated liposomal system for improved delivery of 5-fluorouracil to brain

(2008) Vandana Soni et al.   JOURNAL OF DRUG TARGETING

Curbing the appetites of the big eaters

(2008) Friedrich C. Luft   JOURNAL OF MOLECULAR MEDICINE-JMM

Docetaxel–Albumin Conjugates: Preparation, In Vitro Evaluation and Biodistribution Studies

(2008) Farnaz Esmaeili et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial

(2008) David J Kuter et al.   LANCET

Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake

(2008) Leanne Hodson et al.   PROGRESS IN LIPID RESEARCH