Synthetic strategies for polypeptides and proteins by chemical ligation

Examination of mercaptobenzyl sulfonates as catalysts for native chemical ligation: application to the assembly of a glycosylated Glucagon-Like Peptide 1 (GLP-1) analogue

(2015) Ben Cowper et al.   CHEMICAL COMMUNICATIONS

One-pot chemical synthesis of small ubiquitin-like modifier protein–peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates

(2015) Emmanuelle Boll et al.   Nature Protocols

Template-directed ligation on repetitive DNA sequences: a chemical method to probe the length of Huntington DNA

(2015) Anika Kern et al.   Chemical Science

Peptideo-Aminoanilides as Crypto-Thioesters for Protein Chemical Synthesis

(2014) Jia-Xing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6

(2014) Andreas Reif et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of A Pore-Forming Antimicrobial Protein, Caenopore-5, by Using Native Chemical Ligation at a Glu-Cys Site

(2014) Karima Medini et al.   CHEMBIOCHEM

Chemical Synthesis of a Synthetic Analogue of the Sialic Acid-Binding Lectin Siglec-7

(2014) Masayuki Izumi et al.   CHEMBIOCHEM

Native chemical ubiquitination using a genetically incorporated azidonorleucine

(2014) Renliang Yang et al.   CHEMICAL COMMUNICATIONS

In situ generation of redox active peptides driven by selenoester mediated native chemical ligation

(2014) Dnyaneshwar B. Rasale et al.   CHEMICAL COMMUNICATIONS

From protein total synthesis to peptide transamidation and metathesis: playing with the reversibility of N,S-acyl or N,Se-acyl migration reactions

(2014) Oleg Melnyk et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins

(2014) Lara R Malins et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis of lucifensin by native chemical ligation and characteristics of its isomer having different disulfide bridge pattern

(2014) Stancho Stanchev et al.   JOURNAL OF PEPTIDE SCIENCE

Templated native chemical ligation: peptide chemistry beyond protein synthesis

(2014) Olalla Vázquez et al.   JOURNAL OF PEPTIDE SCIENCE

Reversible Native Chemical Ligation: A Facile Access to Dynamic Covalent Peptides

(2014) Yves Ruff et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry

(2014) Robert E. Thompson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Native Chemical Ligation: A Boon to Peptide Chemistry

(2014) Parashar Thapa et al.   MOLECULES

Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation

(2014) H. van de Langemheen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient Synthesis of Protein Mimics by Sequential Native Chemical Ligation

(2014) Helmus van de Langemheen et al.   ORGANIC LETTERS

Total Synthesis of Polydiscamides B, C, and D via a Convergent Native Chemical Ligation–Oxidation Strategy

(2014) Gajan Santhakumar et al.   ORGANIC LETTERS

Selenopeptide Transamidation and Metathesis

(2014) Nathalie Ollivier et al.   ORGANIC LETTERS

Access to Large Cyclic Peptides by a One-Pot Two-Peptide Segment Ligation/Cyclization Process

(2014) Emmanuelle Boll et al.   ORGANIC LETTERS

Ionic liquid 1-ethyl-3-methylimidazolium acetate: an attractive solvent for native chemical ligation of peptides

(2014) Toni Kühl et al.   TETRAHEDRON LETTERS

Expressed Protein Ligation at Methionine: N-Terminal Attachment of Homocysteine, Ligation, and Masking

(2013) Tomohiro Tanaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Efficient Catalyst for Oxime Ligation and Hydrazone–Oxime Exchange Suitable for Bioconjugation

(2013) Mohammad Rashidian et al.   BIOCONJUGATE CHEMISTRY

Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

(2013) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Total synthesis of biotinylated N domain of human hepatocyte growth factor

(2013) Laurent Raibaut et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Large scale modification of biomolecules using immobilized sortase A from Staphylococcus aureus

(2013) Max Steinhagen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The role of reactivity in DNA templated native chemical PNA ligation during PCR

(2013) Alexander Roloff et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of antimicrobial activity of N-terminal modified Leucocin A analogues

(2013) Krishna Chaitanya Bodapati et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Examination of native chemical ligation using peptidyl prolyl thioesters

(2013) Takahiro Nakamura et al.   CHEMICAL COMMUNICATIONS

Ionic liquids as reaction media for oxidative folding and native chemical ligation of cysteine-containing peptides

(2013) Miriam Böhm et al.   JOURNAL OF MOLECULAR LIQUIDS

Peptide ligation chemistry at selenol amino acids

(2013) Lara R. Malins et al.   JOURNAL OF PEPTIDE SCIENCE

Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography

(2013) Bobo Dang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Methods for Peptide and Protein Production

(2013) Saranya Chandrudu et al.   MOLECULES

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates

(2013) Ji-Shen Zheng et al.   Nature Protocols

Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine

(2013) B. Lewandowski et al.   SCIENCE

Toward waste-free peptide synthesis using ionic reagents and ionic liquids as solvents

(2013) Nicolas Galy et al.   TETRAHEDRON LETTERS

Highly efficient one-pot ligation and desulfurization

(2013) Tal Moyal et al.   Chemical Science

Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

(2012) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Protein Synthesis by Chemoselective α-Ketoacid-Hydroxylamine (KAHA) Ligations with 5-Oxaproline

(2012) Vijaya R. Pattabiraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential α-Ketoacid-Hydroxylamine (KAHA) Ligations: Synthesis of C-Terminal Variants of the Modifier Protein UFM1

(2012) Ayodele O. Ogunkoya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strategic Use of Non-Native Diselenide Bridges to Steer Oxidative Protein Folding

(2012) Norman Metanis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

(2012) Pieter Van de Vijver et al.   CHEMICAL COMMUNICATIONS

Sequential native peptide ligation strategies for total chemical protein synthesis

(2012) Laurent Raibaut et al.   CHEMICAL SOCIETY REVIEWS

Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation

(2012) Sunithi Gunasekera et al.   International Journal of Peptide Research and Therapeutics

Native chemical ligation in dimethylformamide can be performed chemoselectively without racemization

(2012) Marc Dittmann et al.   JOURNAL OF PEPTIDE SCIENCE

Reverse thioether ligation route to multimeric peptide antigens

(2012) Marta Monsó et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Utility of β-Selenol-Phenylalanine for Native Chemical Ligation–Deselenization Chemistry

(2012) Lara R. Malins et al.   ORGANIC LETTERS

Access to Cyclic or Branched Peptides Using Bis(2-sulfanylethyl)amido Side-Chain Derivatives of Asp and Glu

(2012) Emmanuelle Boll et al.   ORGANIC LETTERS

Native Chemical Ligation at Glutamine

(2012) Peter Siman et al.   ORGANIC LETTERS

A Pictet-Spengler ligation for protein chemical modification

(2012) P. Agarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-directed formation of peptide bond: a model study toward DNA-programmed peptide ligation

(2012) Chi Zhang et al.   TETRAHEDRON

Bioorthogonal reactions challenged: DNA templated native chemical ligation during PCR

(2012) Alexander Roloff et al.   Chemical Science

Combinatorial Synthesis of Peptidomimetics Using Digital Microfluidics

(2012) Mais J. Jebrail et al.   Journal of Flow Chemistry

A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

(2011) Nathalie Ollivier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preformed Selenoesters Enable Rapid Native Chemical Ligation at Intractable Sites

(2011) Thomas Durek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides

(2011) Anne Erben et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The availability of urinary gamma-glutamyltransferase as a screening for osteoporosis

(2011) S. Tanaka et al.   BONE

Ascorbate as an Alternative to Thiol Additives in Native Chemical Ligation

(2011) Heike Rohde et al.   CHEMBIOCHEM

N-Sulfanylethylanilide Peptide as a Crypto-Thioester Peptide

(2011) Kohei Sato et al.   CHEMBIOCHEM

Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2

(2011) Jason P. Hallett et al.   CHEMICAL REVIEWS

Synthesis and Functional Characterization of Tridegin and Its Analogues: Inhibitors and Substrates of Factor XIIIa

(2011) Miriam Böhm et al.   ChemMedChem

Fmoc Synthesis of Peptide Thioesters without Post-Chain-Assembly Manipulation

(2011) Ji-Shen Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aziridine-Mediated Ligation and Site-Specific Modification of Unprotected Peptides

(2011) Frank Brock Dyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microwave-assisted chemical ligation of S-acyl peptides containing non-terminal cysteine residues

(2011) Finn K. Hansen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-to-C Sequential Ligation Using Peptidyl N,N-Bis(2-mercaptoethyl)amide Building Blocks

(2011) Renliang Yang et al.   ORGANIC LETTERS

Orthogonal ligation to spherical polymeric microparticles: Modular approaches for surface tailoring

(2011) Anja S. Goldmann et al.   PROGRESS IN POLYMER SCIENCE

Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide

(2011) Youhei Sohma et al.   TETRAHEDRON LETTERS

Synthesis of human GLP-1 (7–36) by chemoselective α-ketoacid–hydroxylamine peptide ligation of unprotected fragments

(2011) Jian Wu et al.   Chemical Science

Traceless Ligation of Cysteine Peptides Using Selective Deselenization

(2010) Norman Metanis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native chemical ligation in the synthesis of internally modified oligonucleotide-peptide conjugates

(2010) Franziska Diezmann et al.   BIOPOLYMERS

Native chemical ligation with Nα acyl transfer auxiliaries

(2010) John Offer   BIOPOLYMERS

Chemoselective Peptidomimetic Ligation Using Thioacid Peptides and Aziridine Templates

(2010) Naila Assem et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bis(2-sulfanylethyl)amino Native Peptide Ligation

(2010) Nathalie Ollivier et al.   ORGANIC LETTERS

PeptidylN,N-Bis(2-mercaptoethyl)-amides as Thioester Precursors for Native Chemical Ligation†

(2010) Wen Hou et al.   ORGANIC LETTERS

Peptide ligation assisted by an auxiliary attached to amidyl nitrogen

(2010) Juan Li et al.   TETRAHEDRON LETTERS

Design and Synthesis of Lipopeptide–Carbohydrate Assembled Multivalent Vaccine Candidates Using Native Chemical Ligation

(2009) Wei Zhong et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Using chemical approaches to study selenoproteins—Focus on thioredoxin reductases

(2009) Robert J. Hondal   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Design, synthesis, and immunochemical characterization of a chimeric glycopeptide corresponding to the Shigella flexneri Y O-polysaccharide and its peptide mimic MDWNMHAA

(2009) B. Rehana Hossany et al.   CARBOHYDRATE RESEARCH

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Biomimetic Synthesis of Lispro Insulin via a Chemically Synthesized “Mini-Proinsulin” Prepared by Oxime-Forming Ligation

(2009) Youhei Sohma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-Phase Peptide Synthesis in Water Using Microwave-Assisted Heating

(2009) Athanassios S. Galanis et al.   ORGANIC LETTERS

Chemoselective Ligation and Modification Strategies for Peptides and Proteins

(2008) Christian P. R. Hackenberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native Chemical Ligation at Valine

(2008) Christian Haase et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoretentive Synthesis and Chemoselective Amide-Forming Ligations of C-Terminal Peptide α-Ketoacids

(2008) Lei Ju et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical synthesis and semisynthesis of membrane proteins

(2008) Diana Olschewski et al.   Molecular BioSystems

2′,2′-Ligation demonstrates the thermal dependence of DNA-directed positional control

(2008) Yu Liu et al.   TETRAHEDRON

Microwave-assisted Boc-solid phase peptide synthesis of cyclic cysteine-rich peptides

(2007) Maša Čemažar et al.   JOURNAL OF PEPTIDE SCIENCE