Comparison of Engineered Liver 3D Models and the Role of Oxygenation for Patient‐Derived Tumor Cells and Immortalized Cell Lines Cocultured with Tumor Stroma in the Detection of Hepatotoxins

Fabrication of oxygen‐carrying microparticles functionalized with liver ECM‐proteins to improve phenotypic three‐dimensional in vitro liver assembly, function, and responses

(2023) Mona Mansouri et al.   BIOTECHNOLOGY AND BIOENGINEERING

Generation of Oxygenating Fluorinated Methacrylamide Chitosan Microparticles to Increase Cell Survival and Function in Large Liver Spheroids

(2022) Mona Mansouri et al.   ACS Applied Materials & Interfaces

Through a glass, darkly? HepaRG and HepG2 cells as models of human Phase I drug metabolism

(2022) Lesley A. Stanley et al.   DRUG METABOLISM REVIEWS

Therapeutic Targeting of Stromal-Tumor HGF-MET Signaling in an Organotypic Triple-Negative Breast Tumor Model

(2022) Sunil Singh et al.   MOLECULAR CANCER RESEARCH

Naringenin and Quercetin Exert Contradictory Cytoprotective and Cytotoxic Effects on Tamoxifen-Induced Apoptosis in HepG2 Cells

(2022) Zhixiang Xu et al.   Nutrients

Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes

(2021) Douglas MacPherson et al.   Scientific Reports

Exploring Interactions between Primary Hepatocytes and Non-Parenchymal Cells on Physiological and Pathological Liver Stiffness

(2021) Vaishaali Natarajan et al.   Biology-Basel

Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity

(2021) Ivan Rusyn et al.   HEPATOLOGY

Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment

(2021) Eman El-Khateeb et al.   MOLECULAR PHARMACEUTICS

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

(2021) Alican Özkan et al.   Frontiers in Oncology

The Curious Case of the HepG2 Cell Line: 40 Years of Expertise

(2021) Viktoriia A. Arzumanian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Optimization and Validation of a Novel Three-Dimensional Co-Culture System in Decellularized Human Liver Scaffold for the Study of Liver Fibrosis and Cancer

(2021) Kessarin Thanapirom et al.   Cancers

U-shaped relationship between urea level and hepatic decompensation in chronic liver diseases

(2021) Huapeng Lin et al.   Clinical and Molecular Hepatology

Metabolic Alterations in Spheroid-Cultured Hepatic Stellate Cells

(2020) Koichi Fujisawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional Models

(2020) David A. Kukla et al.   GENE EXPRESSION

Reduction in CYP1A1 and 2B2 activity at low oxygen tension

(2020) L. Hernández-Gutiérrez et al.   TOXICOLOGY LETTERS

Effect of laminin, polylysine and cell medium components on the attachment of human hepatocellular carcinoma cells to cellulose nanofibrils analyzed by surface plasmon resonance

(2020) Xue Zhang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative Size-Based Analysis of Tumor Spheroids and Responses to Therapeutics

(2019) Pradip Shahi Thakuri et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis

(2019) Piero Pingitore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spatial control of oxygen delivery to three‐dimensional cultures alters cancer cell growth and gene expression

(2019) William J. Wulftange et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Death Receptor Interactions With the Mitochondrial Cell Death Pathway During Immune Cell-, Drug- and Toxin-Induced Liver Damage

(2019) Valentina Spinnenhirn et al.   Frontiers in Cell and Developmental Biology

Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro

(2019) Marta Osrodek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures

(2018) Yuichi Yokoyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

(2018) Bhagwat Prasad et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Necrotic Core and Hypoxic Zone of Multicellular Spheroids in a Microbioreactor with a U-Shaped Barrier

(2018) Maryam Barisam et al.   Micromachines

Hydrogel microenvironments for cancer spheroid growth and drug screening

(2018) Yunfeng Li et al.   Science Advances

Fluorinated methacrylamide chitosan hydrogel dressings enhance healing in an acute porcine wound model

(2018) Pritam S. Patil et al.   PLoS One

Cyclical Treatment of Colorectal Tumor Spheroids Induces Resistance to MEK Inhibitors

(2018) Pradip Shahi Thakuri et al.   Translational Oncology

Characterisation of a functional rat hepatocyte spheroid model

(2018) Jonathan A. Kyffin et al.   TOXICOLOGY IN VITRO

Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development

(2017) Matthew D. Davidson et al.   Integrative Biology

Bringing 3D tumor models to the clinic - predictive value for personalized medicine

(2017) Kathrin Halfter et al.   Biotechnology Journal

Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo

(2017) Hong-Ryul Jung et al.   Scientific Reports

Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model

(2016) Nina K.L. Ma et al.   BIOMATERIALS

Multiparametric Analysis of Oncology Drug Screening with Aqueous Two-Phase Tumor Spheroids

(2016) Pradip Shahi Thakuri et al.   MOLECULAR PHARMACEUTICS

Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions

(2016) Hon Fai Chan et al.   Small

Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors

(2016) Stephanie L. Ham et al.   Advanced Healthcare Materials

Preparation of a sponge-like biocomposite agarose–chitosan scaffold with primary hepatocytes for establishing an in vitro 3D liver tissue model

(2015) Anuj Tripathi et al.   RSC Advances

Encapsulated Neural Stem Cell Neuronal Differentiation in Fluorinated Methacrylamide Chitosan Hydrogels

(2013) Hang Li et al.   ANNALS OF BIOMEDICAL ENGINEERING

Fluorinated methacrylamide chitosan hydrogel systems as adaptable oxygen carriers for wound healing

(2012) Asanka Wijekoon et al.   Acta Biomaterialia

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids

(2012) Takahisa Anada et al.   BIOMATERIALS

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

A robust high-throughput sandwich cell-based drug screening platform

(2010) Shufang Zhang et al.   BIOMATERIALS

The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

(2010) Hui-Min Yan et al.   TOXICOLOGICAL SCIENCES

Involvement of mTOR and survivin inhibition in tamoxifen-induced apoptosis in human hepatoblastoma cell line HepG2

(2009) Renhua Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Towards an Extended Functional Hepatocyte In Vitro Culture

(2008) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS