Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

(2012) Pedro M Quirós et al.   EMBO JOURNAL

Rsk-mediated phosphorylation and 14-3-3ε binding of Apaf-1 suppresses cytochromec-induced apoptosis

(2012) Jiyeon Kim et al.   EMBO JOURNAL

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

A Nuclear-Localized Fluorescent Hydrogen Peroxide Probe for Monitoring Sirtuin-Mediated Oxidative Stress Responses In Vivo

(2011) Bryan C. Dickinson et al.   CHEMISTRY & BIOLOGY

Specific nitration of tyrosines 46 and 48 makes cytochromecassemble a non-functional apoptosome

(2011) José M. García-Heredia et al.   FEBS LETTERS

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

(2011) Patricia Back et al.   FREE RADICAL BIOLOGY AND MEDICINE

Permeabilization of the Mitochondrial Outer Membrane by Bax/Truncated Bid (tBid) Proteins as Sensitized by Cardiolipin Hydroperoxide Translocation

(2011) Witold Korytowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl-xLregulates mitochondrial energetics by stabilizing the inner membrane potential

(2011) Ying-bei Chen et al.   JOURNAL OF CELL BIOLOGY

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3

(2011) Shujun Yuan et al.   STRUCTURE

Crystal Structure of Full-Length Apaf-1: How the Death Signal Is Relayed in the Mitochondrial Pathway of Apoptosis

(2011) Thomas Frank Reubold et al.   STRUCTURE

The Frequency of 1,4-Benzoquinone-Lysine Adducts in Cytochrome c Correlate with Defects in Apoptosome Activation

(2011) Ashley A. Fisher et al.   TOXICOLOGICAL SCIENCES

Cytochrome c is rapidly reduced in the cytosol after mitochondrial outer membrane permeabilization

(2010) Maureen O. Ripple et al.   APOPTOSIS

A genetically encoded sensor for H2O2 with expanded dynamic range

(2010) Kseniya N. Markvicheva et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of the Apaf-1-caspase-9 apoptosome

(2010) S. B. Bratton et al.   JOURNAL OF CELL SCIENCE

Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice

(2010) Nicolas Godin et al.   KIDNEY INTERNATIONAL

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Structure of an Apoptosome-Procaspase-9 CARD Complex

(2010) Shujun Yuan et al.   STRUCTURE

Essentials for ATP Synthesis by F1F0ATP Synthases

(2009) Christoph von Ballmoos et al.   Annual Review of Biochemistry

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1

(2009) Yong Zuo et al.   CELL RESEARCH

Cardiac-Specific Overexpression of Catalase Identifies Hydrogen Peroxide-Dependent and -Independent Phases of Myocardial Remodeling and Prevents the Progression to Overt Heart Failure in Gαq-Overexpressing Transgenic Mice

(2009) Fuzhong Qin et al.   Circulation-Heart Failure

The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

(2009) Srinivas Malladi et al.   EMBO JOURNAL

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

(2009) Soumya Sinha Roy et al.   EMBO REPORTS

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis

(2009) C. Morel et al.   MOLECULAR AND CELLULAR BIOLOGY

Disruption of the M80-Fe ligation stimulates the translocation of cytochromecto the cytoplasm and nucleus in nonapoptotic cells

(2009) Luiz C. Godoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of caspase-3 activity and activation by protein glutathionylation

(2008) Zhishan Huang et al.   BIOCHEMICAL PHARMACOLOGY

Marked difference in cytochrome c oxidation mediated by HO· and/or O2·− free radicals in vitro

(2008) Juliette Thariat et al.   BIOCHIMIE

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

(2008) Anne Seifert et al.   FEBS Journal

Oxidative modification of cytochrome c by singlet oxygen

(2008) Junhwan Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitration of Solvent-exposed Tyrosine 74 on CytochromecTriggers Heme Iron-Methionine 80 Bond Disruption

(2008) Luciano A. Abriata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

(2008) Ryuji Yamaguchi et al.   MOLECULAR CELL

PHAPI, CAS, and Hsp70 Promote Apoptosome Formation by Preventing Apaf-1 Aggregation and Enhancing Nucleotide Exchange on Apaf-1

(2008) Hyun-Eui Kim et al.   MOLECULAR CELL

Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins

(2008) M. Benhar et al.   SCIENCE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY