Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins and Enhances ATG8/LC3 in Caenorhabditis elegans

Autophagy in the light of sphingolipid metabolism

(2015) Eva Bang Harvald et al.   APOPTOSIS

Preface to the Special Issue on brain lipids

(2015) Anthony H. Futerman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions

(2015) Ashraf Virmani et al.   MOLECULAR NEUROBIOLOGY

Sphingolipids in Major Depression

(2015) Peter L. Jernigan et al.   NEUROSIGNALS

New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia

(2014) Avia Merenlender-Wagner et al.   Autophagy

Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons

(2014) Wei Shen et al.   JOURNAL OF NEUROCHEMISTRY

Transient Receptor Potential Melastatin (TRPM) Channels Mediate Clozapine-induced Phenotypes inCaenorhabditis elegans

(2014) Xin Wang et al.   JOURNAL OF NEUROGENETICS

Fluphenazine Reduces Proteotoxicity in C. elegans and Mammalian Models of Alpha-1-Antitrypsin Deficiency

(2014) Jie Li et al.   PLoS One

Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs

(2014) Donard S. Dwyer et al.   Frontiers in Pharmacology

Autophagy has a key role in the pathophysiology of schizophrenia

(2013) A Merenlender-Wagner et al.   MOLECULAR PSYCHIATRY

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study

(2013) Michelle M. Mielke et al.   PLoS One

Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans

(2013) Mai-Britt Mosbech et al.   PLoS One

A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target

(2013) Taixiang Saur et al.   PLoS Genetics

Dopamine D2 Receptor Antagonism Suppresses Tau Aggregation and Neurotoxicity

(2012) Allyson V. McCormick et al.   BIOLOGICAL PSYCHIATRY

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Skin Ceramide Alterations in First-Episode Schizophrenia Indicate Abnormal Sphingolipid Metabolism

(2012) Stefan Smesny et al.   SCHIZOPHRENIA BULLETIN

Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs

(2012) Julia Gohlke   Frontiers in Psychiatry

Behavioral effects of clozapine: Involvement of trace amine pathways in C. elegans and M. musculus

(2011) Rakesh Karmacharya et al.   BRAIN RESEARCH

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

Effect of clozapine on the dimerization of serotonin 5-HT2A receptor and its genetic variant 5-HT2AH425Y with dopamine D2 receptor

(2011) Sylwia Łukasiewicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division

(2011) K. H. Nomura et al.   GLYCOBIOLOGY

The effect of clozapine on the AMPK-ACC-CPT1 pathway in the rat frontal cortex

(2011) Min Kyung Kim et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis

(2011) Hongjie Zhang et al.   NATURE CELL BIOLOGY

Sphingolipid abnormalities in psychiatric disorders: a missing link in pathology?

(2010) Sujatha Narayan   Frontiers in Bioscience-Landmark

The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases

(2010) Oshrit Ben-David et al.   NEUROMOLECULAR MEDICINE

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

(2010) Sager J. Gosai et al.   PLoS One

Ceramide-induced autophagy: To junk or to protect cells?

(2009) Sophie Pattingre et al.   Autophagy

Systemic regulation of starvation response in Caenorhabditis elegans

(2009) C. Kang et al.   GENES & DEVELOPMENT

Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells

(2009) E. Marza et al.   JOURNAL OF CELL SCIENCE

Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin-Signaling Pathway in Caenorhabditis elegans

(2009) Rakesh Karmacharya et al.   NEUROPSYCHOPHARMACOLOGY

Behavioral adaptation in C. elegans produced by antipsychotic drugs requires serotonin and is associated with calcium signaling and calcineurin inhibition

(2009) Dallas R. Donohoe et al.   NEUROSCIENCE RESEARCH

Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase

(2009) V. Menuz et al.   SCIENCE

Evidence for disruption of sphingolipid metabolism in schizophrenia

(2008) Sujatha Narayan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

High Throughput Lipidomic Profiling of Schizophrenia and Bipolar Disorder Brain Tissue Reveals Alterations of Free Fatty Acids, Phosphatidylcholines, and Ceramides

(2008) Emanuel Schwarz et al.   JOURNAL OF PROTEOME RESEARCH

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

(2008) J. A. Lieberman et al.   PHARMACOLOGICAL REVIEWS

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

(2008) X. Deng et al.   SCIENCE