Epigallocatechin Gallate Attenuates β-Amyloid Generation and Oxidative Stress Involvement of PPARγ in N2a/APP695 Cells

Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation

(2016) Neha Rani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

(-)-Epigallocatechin-3-gallate (EGCG) attenuates arsenic-induced cardiotoxicity in rats

(2016) Tao-Li Sun et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice

(2016) Kunmu Zheng et al.   MOLECULAR NEUROBIOLOGY

Astragaloside IV, a Natural PPARγ Agonist, Reduces Aβ Production in Alzheimer’s Disease Through Inhibition of BACE1

(2016) Xu Wang et al.   MOLECULAR NEUROBIOLOGY

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways

(2016) Zhao Gao et al.   PLoS One

The Effect of (-)-Epigallocatechin-3-Gallate on IL-1β Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated Ophthalmopathy

(2016) Ji-Young Lee et al.   PLoS One

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

All-trans-retinoic Acid ReducesBACE1Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling

(2015) Ruishan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells

(2015) Nan Lin et al.   MOLECULAR NEUROBIOLOGY

Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage byZanthoxylum alatum

(2015) Indrajit Karmakar et al.   PHARMACEUTICAL BIOLOGY

Neuroprotective effects of pioglitazone against transient cerebral ischemic reperfusion injury in diabetic rats: Modulation of antioxidant, anti-inflammatory, and anti-apoptotic biomarkers

(2015) Ayman E. El-Sahar et al.   Pharmacological Reports

Cognitive Enhancing Treatment with a PPARγ Agonist Normalizes Dentate Granule Cell Presynaptic Function in Tg2576 APP Mice

(2014) Miroslav N. Nenov et al.   JOURNAL OF NEUROSCIENCE

PPARα Activation Sensitizes Cancer Cells to Epigallocatechin-3-Gallate (EGCG) Treatment via Suppressing Heme Oxygenase-1

(2014) Shuyu Zhang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation

(2013) Li-ping Liu et al.   ACTA PHARMACOLOGICA SINICA

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice

(2013) Emma Barroso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

(2013) Ruishan Wang et al.   Cell Metabolism

Involvement of α7 nAChR Signaling Cascade in Epigallocatechin Gallate Suppression of β-Amyloid-Induced Apoptotic Cortical Neuronal Insults

(2013) Xijing Zhang et al.   MOLECULAR NEUROBIOLOGY

Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

(2013) Mágada T. Schwalm et al.   MOLECULAR NEUROBIOLOGY

Ginsenoside Rg1 Decreases Aβ1–42 Level by Upregulating PPARγ and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease

(2013) QianKun Quan et al.   PLoS One

PPARγ Agonist Pioglitazone Reverses Memory Impairment and Biochemical Changes in a Mouse Model of Type 2 Diabetes Mellitus

(2012) Li-Ying Jiang et al.   CNS Neuroscience & Therapeutics

The neurotoxicity of β-amyloid peptide toward rat brain is associated with enhanced oxidative stress, inflammation and apoptosis, all of which can be attenuated by scutellarin

(2012) Li-Li Guo et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)

(2012) Yingjun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects

(2012) Brian Hitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Autophagy in nuclear receptor PPARγ-deficient mouse prostatic carcinogenesis

(2010) Ming Jiang et al.   Autophagy

Anticonvulsant potential of the peroxisome proliferator-activated receptor gamma agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice

(2010) Dalaal M. Abdallah   BRAIN RESEARCH

Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents

(2010) R.K. Kaundal et al.   DRUG NEWS & PERSPECTIVES

BACE1 Gene Promoter Single-Nucleotide Polymorphisms in Alzheimer’s Disease

(2010) Weihui Zhou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The nuclear receptor PPARγ as a therapeutic target for cerebrovascular and brain dysfunction in Alzheimer's disease

(2010) Nektaria Nicolakakis   Frontiers in Aging Neuroscience

Neuroprotective effects of (−)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition

(2009) Sujeong Jang et al.   BRAIN RESEARCH

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

(2009) Soraya L. Valles et al.   BRAIN RESEARCH

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation

(2009) Yoshiari Shimmyo et al.   NEUROREPORT

Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation

(2008) M. S. Song et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Translational Control of BACE1 May Go Awry in Alzheimer's Disease

(2008) Philip C. Wong   NEURON

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE