Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells

Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease

(2015) Yuqi Zeng et al.   JOURNAL OF NEUROCHEMISTRY

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

(2014) Virginie Buggia-Prévot et al.   Molecular Neurodegeneration

BACE1 activity regulates cell surface contactin-2 levels

(2014) Vivek Gautam et al.   Molecular Neurodegeneration

Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice

(2013) Nan Lin et al.   BEHAVIOURAL BRAIN RESEARCH

Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice

(2013) Gehad M. Subaiea et al.   NEUROBIOLOGY OF AGING

Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents

(2011) Kwong-Fai Wong et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

(2010) David W. Klaver et al.   BIOLOGICAL CHEMISTRY

Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons

(2009) Hyun Jin Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tripchlorolide protects neuronal cells from microglia-mediated β-amyloid neurotoxicity through inhibiting NF-κB and JNK signaling

(2009) Xiao-Dong Pan et al.   GLIA

Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia

(2008) Xiao-dong Pan et al.   BIOCHEMICAL PHARMACOLOGY

Understanding BACE1: essential protease for amyloid-β production in Alzheimer’s disease

(2008) J. H. Stockley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42

(2008) Virginie Buggia-Prevot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY