Update on the genetic architecture of rheumatoid arthritis

A twin study of rheumatoid arthritis in the Japanese population

(2016) Chikashi Terao et al.   Modern Rheumatology

Significant impact of miRNA–target gene networks on genetics of human complex traits

(2016) Yukinori Okada et al.   Scientific Reports

A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles

(2016) Kirsten M. Anderson et al.   Arthritis & Rheumatology

Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2016) Kwangwoo Kim et al.   PLoS One

Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis

(2016) Kwangwoo Kim et al.   Scientific Reports

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci

(2015) Gosia Trynka et al.   AMERICAN JOURNAL OF HUMAN GENETICS

UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases

(2015) Myles J. Lewis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies

(2015) Gleb Kichaev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes

(2015) Lude Franke et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels

(2015) T C Messemaker et al.   GENES AND IMMUNITY

The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection

(2015) Cornelia Schuster et al.   IMMUNITY

Association of HLA-DRB1 Haplotypes With Rheumatoid Arthritis Severity, Mortality, and Treatment Response

(2015) Sebastien Viatte et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cutting Edge: Chronic NF-κB Activation in CD4+T Cells in Rheumatoid Arthritis Is Genetically Determined by HLA Risk Alleles

(2015) Charles F. Spurlock et al.   JOURNAL OF IMMUNOLOGY

Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis

(2015) Joanna L. Giles et al.   JOURNAL OF IMMUNOLOGY

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(2015) Jan Freudenberg et al.   MOLECULAR MEDICINE

Super-enhancers delineate disease-associated regulatory nodes in T cells

(2015) Golnaz Vahedi et al.   NATURE

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

(2015) Xinli Hu et al.   NATURE GENETICS

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

(2015) Tobias L Lenz et al.   NATURE GENETICS

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

(2015) Mary D Fortune et al.   NATURE GENETICS

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

(2015) Dorothée Diogo et al.   PLoS One

C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis

(2015) Munitta Muthana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci

(2015) Paul Martin et al.   Nature Communications

The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis

(2015) Hui-Hsin Chang et al.   Arthritis & Rheumatology

Interactions Between Amino Acid-Defined Major Histocompatibility Complex Class II Variants and Smoking in Seropositive Rheumatoid Arthritis

(2015) Kwangwoo Kim et al.   Arthritis & Rheumatology

The Rheumatoid Arthritis Risk GeneLBHRegulates Growth in Fibroblast-like Synoviocytes

(2015) Anna-Karin H. Ekwall et al.   Arthritis & Rheumatology

Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms

(2015) Ole A. Andreassen et al.   PLoS One

Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity

(2014) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

(2014) L Bossini-Castillo et al.   ANNALS OF THE RHEUMATIC DISEASES

High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci

(2014) Kwangwoo Kim et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of novel therapeutics for complex diseases from genome-wide association data

(2014) Mani P Grover et al.   BMC Medical Genomics

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

The intersection of immune deficiency and autoimmunity

(2014) Solrun M. Maggadottir et al.   CURRENT OPINION IN RHEUMATOLOGY

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations

(2014) Yukinori Okada et al.   HUMAN MOLECULAR GENETICS

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene

(2014) Yukinori Okada et al.   PLoS One

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

Targeted exon sequencing fails to identify rare coding variants with large effect in rheumatoid arthritis

(2014) So-Young Bang et al.   ARTHRITIS RESEARCH & THERAPY

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

(2014) Barbara Hrdlickova et al.   Genome Medicine

Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells

(2014) Xinli Hu et al.   PLoS Genetics

Association ofFCGR3AandFCGR3BCopy Number Variations With Systemic Lupus Erythematosus and Rheumatoid Arthritis in Taiwanese Patients

(2014) Ji-Yih Chen et al.   Arthritis & Rheumatology

HLA-DRB1-Associated Rheumatoid Arthritis Risk at Multiple Levels in African Americans: Hierarchical Classification Systems, Amino Acid Positions, and Residues

(2014) Richard J. Reynolds et al.   Arthritis & Rheumatology

Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 ‘shared epitope’ alleles

(2013) Catriona A Wagner et al.   ANNALS OF THE RHEUMATIC DISEASES

Brief Report: Identification ofBACH2andRAD51Bas Rheumatoid Arthritis Susceptibility Loci in a Meta-Analysis of Genome-Wide Data

(2013) Kate McAllister et al.   ARTHRITIS AND RHEUMATISM

Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA

(2013) A Yarwood et al.   GENES AND IMMUNITY

A 129-kb Deletion on Chromosome 12 Confers Substantial Protection Against Rheumatoid Arthritis, Implicating the GeneSLC2A3

(2013) Colin D. Veal et al.   HUMAN MUTATION

Interaction of HLA-DRB1*09:01 and *04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope

(2013) S.-Y. Bang et al.   JOURNAL OF RHEUMATOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

On the Origin of Rheumatoid Arthritis: The Impact of Environment and Genes—A Population Based Twin Study

(2013) Anders J. Svendsen et al.   PLoS One

The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling

(2013) María Luisa de la Puerta et al.   PLoS One

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

Identification of the Tyrosine-Protein Phosphatase Non-Receptor Type 2 as a Rheumatoid Arthritis Susceptibility Locus in Europeans

(2013) Joanna E. Cobb et al.   PLoS One

Measles Contributes to Rheumatoid Arthritis: Evidence from Pathway and Network Analyses of Genome-Wide Association Studies

(2013) Guiyou Liu et al.   PLoS One

Integrative Pathway-Based Approach for Genome-Wide Association Studies: Identification of New Pathways for Rheumatoid Arthritis and Type 1 Diabetes

(2013) Finja Büchel et al.   PLoS One

An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes

(2013) K. Shimane et al.   RHEUMATOLOGY

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

(2013) S. Carpenter et al.   SCIENCE

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

(2013) Gang Li et al.   PLoS Genetics

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

(2013) Ricardo C. Ferreira et al.   PLoS Genetics

Quantifying Missing Heritability at Known GWAS Loci

(2013) Alexander Gusev et al.   PLoS Genetics

Novel Rheumatoid Arthritis Susceptibility Locus at 22q12 Identified in an Extended UK Genome-Wide Association Study

(2013) Gisela Orozco et al.   Arthritis & Rheumatology

Contribution of FunctionalLILRA3, but Not NonfunctionalLILRA3, to Sex Bias in Susceptibility and Severity of Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis

(2013) Yan Du et al.   Arthritis & Rheumatology

Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12

(2012) Fina A.S. Kurreeman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis

(2012) Dorothée Diogo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients

(2012) Sebastien Viatte et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

(2012) Diederik P C de Rooy et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of an activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype with increased susceptibility to rheumatoid arthritis

(2012) Tae-Un Han et al.   ARTHRITIS AND RHEUMATISM

Different effects of biological drugs in rheumatoid arthritis

(2012) Fabiola Atzeni et al.   AUTOIMMUNITY REVIEWS

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Whole-genome detection of disease-associated deletions or excess homozygosity in a case-control study of rheumatoid arthritis

(2012) C.-C. Wu et al.   HUMAN MOLECULAR GENETICS

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

(2012) Yukinori Okada et al.   NATURE GENETICS

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

(2012) Eli A Stahl et al.   NATURE GENETICS

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Genetic Basis of Autoantibody Positive and Negative Rheumatoid Arthritis Risk in a Multi-ethnic Cohort Derived from Electronic Health Records

(2011) Fina Kurreeman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets

(2011) Xinli Hu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects

(2011) C. Terao et al.   ANNALS OF THE RHEUMATIC DISEASES

The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse

(2011) J. T. Eppig et al.   NUCLEIC ACIDS RESEARCH

Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling

(2010) George Stratigopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits

(2010) Ayellet V. Segrè et al.   PLoS Genetics

Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis

(2009) Diane van der Woude et al.   ARTHRITIS AND RHEUMATISM

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS