Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

Impact of the CD40-CD40L Dyad in Alzheimers Disease

(2012) Brian Giunta et al.   CNS & Neurological Disorders-Drug Targets

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial

(2012) Evan A Stein et al.   LANCET

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles

(2012) Benjamin P Fairfax et al.   NATURE GENETICS

Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol

(2012) Evan A. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

The CD40-CD40L system in cardiovascular disease

(2011) Burak Pamukcu et al.   ANNALS OF MEDICINE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

(2011) J. Xu et al.   SCIENCE

Reengineering Translational Science: The Time Is Right

(2011) F. S. Collins   Science Translational Medicine

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

(2011) R. Huang et al.   Science Translational Medicine

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

(2011) Rudolf S. N. Fehrmann et al.   PLoS Genetics

The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice

(2010) N Shiota et al.   BRITISH JOURNAL OF PHARMACOLOGY

Research Article: Effective and Specific Inhibition of the CD40-CD154 Costimulatory Interaction by a Naphthalenesulphonic Acid Derivative

(2010) Emilio Margolles-Clark et al.   Chemical Biology & Drug Design

Inhibition of Osteoclast Bone Resorption by Disrupting Vacuolar H+-ATPasea3-B2 Subunit Interaction

(2010) Norbert Kartner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Cell-Based Assays for High-Throughput Screening

(2010) W. Frank An et al.   MOLECULAR BIOTECHNOLOGY

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes

(2010) S. Y. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis

(2010) Xiufen Zheng et al.   ARTHRITIS RESEARCH & THERAPY

GWASs and the age of human as the model organism for autoimmune genetic research

(2010) Robert Plenge   GENOME BIOLOGY

Primary B Cell Immunodeficiencies: Comparisons and Contrasts

(2009) Mary Ellen Conley et al.   Annual Review of Immunology

CD40/CD40L signaling and its implication in health and disease

(2009) Antonios Chatzigeorgiou et al.   BIOFACTORS

Rheumatoid arthritis

(2009) Lars Klareskog et al.   LANCET

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

(2009) Sekar Kathiresan et al.   NATURE GENETICS

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

(2008) Soumya Raychaudhuri et al.   NATURE GENETICS

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of  -thalassemia

(2008) M. Uda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE