Beyond pan-B-cell-directed therapy — new avenues and insights into the pathogenesis of SLE
出版年份 2016 全文链接
标题
Beyond pan-B-cell-directed therapy — new avenues and insights into the pathogenesis of SLE
作者
关键词
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出版物
Nature Reviews Rheumatology
Volume 12, Issue 11, Pages 645-657
出版商
Springer Nature
发表日期
2016-10-13
DOI
10.1038/nrrheum.2016.158
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus
- (2016) Madhvi Menon et al. IMMUNITY
- Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells
- (2016) Andrew Getahun et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Resolution of inflammation: a new therapeutic frontier
- (2016) James N. Fullerton et al. NATURE REVIEWS DRUG DISCOVERY
- Plasma cells as an innovative target in autoimmune disease with renal manifestations
- (2016) Falk Hiepe et al. Nature Reviews Nephrology
- Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
- (2015) Caroline von Spee-Mayer et al. ANNALS OF THE RHEUMATIC DISEASES
- Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE
- (2015) Jens Y Humrich et al. ANNALS OF THE RHEUMATIC DISEASES
- The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus
- (2015) Tobias Alexander et al. ANNALS OF THE RHEUMATIC DISEASES
- Efficacy and safety of subcutaneous tabalumab, a monoclonal antibody to B-cell activating factor, in patients with systemic lupus erythematosus: results from ILLUMINATE-2, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study
- (2015) J T Merrill et al. ANNALS OF THE RHEUMATIC DISEASES
- A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)
- (2015) Kenneth C Kalunian et al. ANNALS OF THE RHEUMATIC DISEASES
- Efficacy and safety of subcutaneous tabalumab in patients with systemic lupus erythematosus: results from ILLUMINATE-1, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study
- (2015) D A Isenberg et al. ANNALS OF THE RHEUMATIC DISEASES
- The mechanistic impact of CD22 engagement with epratuzumab on B cell function: Implications for the treatment of systemic lupus erythematosus
- (2015) Thomas Dörner et al. AUTOIMMUNITY REVIEWS
- Targeting Interferons in Systemic Lupus Erythematosus: Current and Future Prospects
- (2015) Alexis Mathian et al. DRUGS
- Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases
- (2015) Andreia C. Lino et al. IMMUNOLOGICAL REVIEWS
- Progress with the use of monoclonal antibodies for the treatment of systemic lupus erythematosus
- (2015) Natasha Jordan et al. Immunotherapy
- Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling
- (2015) Derek A. Holmes et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Treatment of coexistent psoriasis and lupus erythematosus
- (2015) Sowmya Varada et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
- (2015) Eoin F. McKinney et al. NATURE
- HDAC inhibitors still need a home run, despite recent approval
- (2015) Malini Guha NATURE REVIEWS DRUG DISCOVERY
- Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma
- (2015) Henk M. Lokhorst et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy
- (2015) Karen M. Doody et al. Science Translational Medicine
- Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus
- (2015) Ji Hyun Sim et al. ARTHRITIS RESEARCH & THERAPY
- Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors
- (2015) Adriano Taddeo et al. ARTHRITIS RESEARCH & THERAPY
- CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study
- (2015) Anthony Shock et al. ARTHRITIS RESEARCH & THERAPY
- Epratuzumab inhibits the production of the proinflammatory cytokines IL-6 and TNF-α, but not the regulatory cytokine IL-10, by B cells from healthy donors and SLE patients
- (2015) Vanessa Fleischer et al. ARTHRITIS RESEARCH & THERAPY
- Manipulation of B-cell responses with histone deacetylase inhibitors
- (2015) Michaela Waibel et al. Nature Communications
- Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus
- (2015) Venkat Reddy et al. Arthritis & Rheumatology
- A phase 2, randomised, placebo-controlled clinical trial of blisibimod, an inhibitor of B cell activating factor, in patients with moderate-to-severe systemic lupus erythematosus, the PEARL-SC study
- (2014) R A Furie et al. ANNALS OF THE RHEUMATIC DISEASES
- Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)
- (2014) David Isenberg et al. ANNALS OF THE RHEUMATIC DISEASES
- The efficacy of novel B cell biologics as the future of SLE treatment: A review
- (2014) Ameer Kamal et al. AUTOIMMUNITY REVIEWS
- Safety of off-label biologicals in systemic lupus erythematosus
- (2014) Martin Aringer et al. Expert Opinion On Drug Safety
- Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus
- (2014) William Stohl EXPERT OPINION ON THERAPEUTIC TARGETS
- MHC associations with clinical and autoantibody manifestations in European SLE
- (2014) D L Morris et al. GENES AND IMMUNITY
- Atacicept in multiple sclerosis (ATAMS): a randomised, placebo-controlled, double-blind, phase 2 trial
- (2014) Ludwig Kappos et al. LANCET NEUROLOGY
- Antibodies to watch in 2015
- (2014) Janice M Reichert mAbs
- IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
- (2014) Ping Shen et al. NATURE
- Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation
- (2014) Julia Sieber et al. ARTHRITIS RESEARCH & THERAPY
- Increased Frequency of a Unique Spleen Tyrosine Kinase Bright Memory B Cell Population in Systemic Lupus Erythematosus
- (2014) Sarah J. Fleischer et al. Arthritis & Rheumatology
- Ustekinumab in the Treatment of Refractory Chronic Cutaneous Lupus Erythematosus: A Case Report
- (2013) C Dahl et al. ACTA DERMATO-VENEREOLOGICA
- Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids
- (2013) Marie B Condon et al. ANNALS OF THE RHEUMATIC DISEASES
- Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study
- (2013) Daniel J Wallace et al. ANNALS OF THE RHEUMATIC DISEASES
- Rituximab Therapy for Primary Sjögren's Syndrome: An Open-Label Clinical Trial and Mechanistic Analysis
- (2013) E. William St.Clair et al. ARTHRITIS AND RHEUMATISM
- Biologics in SLE: Towards new approaches
- (2013) Ronald F. van Vollenhoven et al. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
- B cells
- (2013) Thomas Dörner et al. CURRENT OPINION IN RHEUMATOLOGY
- Exacerbated Autoimmunity in the Absence of TLR9 in MRL.Faslpr Mice Depends on Ifnar1
- (2013) K. M. Nickerson et al. JOURNAL OF IMMUNOLOGY
- Immunopathogenic mechanisms of systemic autoimmune disease
- (2013) Marie Wahren-Herlenius et al. LANCET
- Rituximab in systemic lupus erythematosus: an updated systematic review and meta-analysis
- (2013) B Duxbury et al. LUPUS
- Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms
- (2013) Chuanxin Huang et al. NATURE IMMUNOLOGY
- How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy
- (2013) Georg Schett et al. NATURE MEDICINE
- Taking a closer look at biologic therapy for SLE
- (2013) David A. Isenberg et al. Nature Reviews Rheumatology
- Emerging cell and cytokine targets in rheumatoid arthritis
- (2013) Gerd R. Burmester et al. Nature Reviews Rheumatology
- Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up
- (2013) Daniel J. Wallace et al. RHEUMATOLOGY
- B-cell depletion in SLE: clinical and trial experience with rituximab and ocrelizumab and implications for study design
- (2013) Venkat Reddy et al. ARTHRITIS RESEARCH & THERAPY
- Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus
- (2012) Yuko Shirota et al. ANNALS OF THE RHEUMATIC DISEASES
- Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis
- (2012) George K Bertsias et al. ANNALS OF THE RHEUMATIC DISEASES
- Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study
- (2012) Brad H. Rovin et al. ARTHRITIS AND RHEUMATISM
- CD22 ligation inhibits downstream B cell receptor signaling and Ca2+flux upon activation
- (2012) N. Sieger et al. ARTHRITIS AND RHEUMATISM
- Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: A randomized, placebo-phase trial
- (2012) Chester V. Oddis et al. ARTHRITIS AND RHEUMATISM
- B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells
- (2012) Matthieu Mahévas et al. JOURNAL OF CLINICAL INVESTIGATION
- Response to ustekinumab in a patient with both severe psoriasis and hypertrophic cutaneous lupus
- (2012) D Winchester et al. LUPUS
- Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
- (2012) Inmoo Rhee et al. NATURE IMMUNOLOGY
- From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
- (2012) Jacques Banchereau et al. NATURE IMMUNOLOGY
- B-cell numbers and phenotype at clinical relapse following rituximab therapy differ in SLE patients according to anti-dsDNA antibody levels
- (2012) Mark N. Lazarus et al. RHEUMATOLOGY
- American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis
- (2012) Bevra H. Hahn et al. ARTHRITIS CARE & RESEARCH
- Successful Treatment of Subacute Lupus Erythematosus With Ustekinumab
- (2011) Aieska De Souza ARCHIVES OF DERMATOLOGY
- B cell biomarkers of rituximab responses in systemic lupus erythematosus
- (2011) Edward M. Vital et al. ARTHRITIS AND RHEUMATISM
- Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial
- (2011) R. F. van Vollenhoven et al. ARTHRITIS AND RHEUMATISM
- Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II, randomized, placebo-controlled, dose-finding trial
- (2011) M. C. Genovese et al. ARTHRITIS AND RHEUMATISM
- A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus
- (2011) Richard Furie et al. ARTHRITIS AND RHEUMATISM
- Targeting BLyS in rheumatic disease: the sometimes-bumpy road from bench to bedside
- (2011) William Stohl et al. CURRENT OPINION IN RHEUMATOLOGY
- An Acquired Defect in IgG-Dependent Phagocytosis Explains the Impairment in Antibody-Mediated Cellular Depletion in Lupus
- (2011) A. Ahuja et al. JOURNAL OF IMMUNOLOGY
- Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
- (2011) Sandra V Navarra et al. LANCET
- Long-lived autoreactive plasma cells drive persistent autoimmune inflammation
- (2011) Falk Hiepe et al. Nature Reviews Rheumatology
- Systemic Lupus Erythematosus
- (2011) George C. Tsokos NEW ENGLAND JOURNAL OF MEDICINE
- B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice
- (2011) P. Scapini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory T cell lineage commitment in the thymus
- (2011) Ludger Klein et al. SEMINARS IN IMMUNOLOGY
- Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
- (2011) Hans-Peter Tony et al. ARTHRITIS RESEARCH & THERAPY
- Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
- (2010) Gabor G. Illei et al. ARTHRITIS AND RHEUMATISM
- CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
- (2010) Paul A. Blair et al. IMMUNITY
- Phenotypic Changes of Lymphocytes in Patients with Systemic Lupus Erythematosus Who Are in Longterm Remission After B Cell Depletion Therapy with Rituximab
- (2010) S. IWATA et al. JOURNAL OF RHEUMATOLOGY
- Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
- (2010) John H. Stone et al. NEW ENGLAND JOURNAL OF MEDICINE
- Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus
- (2010) Capucine Daridon et al. ARTHRITIS RESEARCH & THERAPY
- Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial
- (2009) Joan T. Merrill et al. ARTHRITIS AND RHEUMATISM
- Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity
- (2009) Vicky Lampropoulou et al. IMMUNOLOGICAL REVIEWS
- A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
- (2009) Vesela Gateva et al. NATURE GENETICS
- B-cell-directed therapies for autoimmune disease
- (2009) Thomas Dörner et al. Nature Reviews Rheumatology
- Class-switched B cells display response to therapeutic B cell depletion in rheumatoid arthritis
- (2009) Burkhard Moller et al. ARTHRITIS RESEARCH & THERAPY
- Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis
- (2009) Maria Rehnberg et al. ARTHRITIS RESEARCH & THERAPY
- B cells in autoimmunity
- (2009) Thomas Dörner et al. ARTHRITIS RESEARCH & THERAPY
- Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response
- (2009) Magda Nakou et al. ARTHRITIS RESEARCH & THERAPY
- Anti-CD20 therapy in patients with rheumatoid arthritis: Predictors of response and B cell subset regeneration after repeated treatment
- (2008) Petra Roll et al. ARTHRITIS AND RHEUMATISM
- Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis
- (2008) Gregg J. Silverman et al. IMMUNOLOGICAL REVIEWS
- The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
- (2008) Kirsten Neubert et al. NATURE MEDICINE
- Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX
- (2008) Geoffrey Hom et al. NEW ENGLAND JOURNAL OF MEDICINE
- B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis
- (2008) Stephen L. Hauser et al. NEW ENGLAND JOURNAL OF MEDICINE
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