期刊
NEUROBIOLOGY OF AGING
卷 35, 期 2, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2013.08.013
关键词
LRRK2; Variants; Alzheimer's disease; Han Chinese
资金
- Ministry of Science and Technology of China [2011CB910900]
- National Natural Science Foundation of China [30925021]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB02020000]
The leucine-rich repeat kinase-2 (LRRK2) gene has been regarded as 1 of the most common genetic causes of Parkinson's disease (PD). We hypothesized that LRRK2-susceptible allele(s) for PD might pose a risk for Alzheimer's disease (AD). In this study, we screened 12 LRRK2 gene variants in 2 independent cohorts from southwestern China (341 AD patients and 435 normal individuals) and eastern China (297 AD patients and 384 normal individuals), to discern the potential association between this gene and AD. No variant was identified to be associated with AD in either case-control sample. As both of the cohorts were of Han Chinese origin, we combined the LRRK2 variant data for the 2 sample sets together (a total of 638 AD patients and 819 normal individuals) and still found no association between the LRRK2 gene and AD, suggesting that LRRK2 gene variants may not affect the development of AD in Han Chinese individuals. (C) 2014 Elsevier Inc. All rights reserved.
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