Article
Andrology
Xiaodan Teng, Yang Liu, Liping Wang, Guonian Wang
Summary: The study found that lidocaine exerts anti-tumor effects in bladder cancer by down-regulating the expression of ICMT, and that high expression of ICMT is closely related to the clinical phenotype of bladder cancer. In addition, lidocaine treatment significantly inhibited the proliferation of bladder cancer cells, promoted apoptosis, and inhibited tumor growth.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Oncology
Weifeng Wan, Wenfeng Xiao, Wen Pan, Ligang Chen, Zhiyong Liu, Jianguo Xu
Summary: This study demonstrates that the upregulation of ICMT expression is associated with glioblastoma, and its pharmacological inhibitors effectively suppress glioblastoma growth and act synergistically with chemotherapy drugs. Therefore, ICMT represents a promising target for the treatment of glioblastoma.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Biology
Jingyi Tang, Patrick J. Casey, Mei Wang
Summary: DNA damage has a dual impact on cancer cells: inducing genomic instability to promote cancer development while compromising proliferation and survival. Inhibiting ICMT reduces MAPK signaling activity, impairs DNA damage repair machinery, leading to cell cycle arrest and apoptosis in cancer cells. ICMT inhibition transforms cancer cells into a BRCA-like state, sensitizing them to PARP inhibitor and other DNA-damaging agents, particularly in anchorage-independent or in vivo conditions.
LIFE SCIENCE ALLIANCE
(2021)
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Pharmacology & Pharmacy
Hanwei Ma, Fahong Wu, Yinliang Bai, Tianwei Wang, Shangxian Ma, Liuqing Guo, Guiyuan Liu, Guangxian Leng, Yin Kong, Youcheng Zhang
Summary: In this study, the effects of licoricidin on gastric cancer cells were comprehensively explored. Licoricidin was found to inhibit proliferation, induce apoptosis, arrest the cell cycle, and inhibit migration and invasion abilities of gastric cancer cells. Through proteomics research, isoprenyl carboxyl methyltransferase (ICMT) was identified as the potential target of licoricidin. Western blot and immunohistochemistry assays confirmed the downregulation of ICMT expression by licoricidin in cells and xenograft tumors. Additionally, licoricidin effectively reduced the level of active Ras-GTP and blocked the phosphorylation of Raf and Erk. These findings suggest that licoricidin exerts its anti-gastric cancer effects via the ICMT/Ras pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Juan Zhang, Qian Xiang, Man Wu, Yuan-Zhi Lao, Yan-Fang Xian, Hong-Xi Xu, Zhi-Xiu Lin
Summary: Autophagy has a dual function in tumor initiation and development by supporting cell survival or inducing cell death. Understanding its complex mechanisms is crucial for guiding cancer treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Fengchao Chen, Siya Zhang, Tongtong Yan, Hongquan Wang, Jie Li, Qiang Wang, Subhan Danish, Kun Li
Summary: This study evaluated the potential photodynamic effect of tanshinone I (TanI), an extract from Danshen herb, in photodynamic therapy. The results showed that TanI could be photoexcited and induce cytotoxic effects in breast cancer cells, including inhibition of cell survival and migration, as well as induction of apoptosis and necrosis. This indicates that TanI may serve as a natural photosensitizer.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Elizaveta Belyaeva, Nina Loginova, Brett A. Schroeder, Ian S. Goldlust, Arbind Acharya, Sandeep Kumar, Peter Timashev, Ilya Ulasov
Summary: The balance between cell death and cell survival involves the breakdown and removal of unnecessary or harmful materials in a controlled manner. Autophagy, initiated by various stresses, is a well-regulated process with specific genes and proteins. Targeting autophagy shows promise as an anti-tumor therapy, but its effects on different tumor cells remain unclear. This review investigates autophagy as a potential therapeutic target for aggressive sarcomas.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: Cancer resistance is a major concern in cancer treatment. Photodynamic therapy (PDT) and photobiomodulation (PBM) can improve therapeutic outcomes, and PBM may enhance the anti-tumor efficacy of ZnPcS4-PDT on resistant MCF-7 breast cancer cells by inducing autophagy.
Review
Chemistry, Multidisciplinary
Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R. Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmandi
Summary: Nanotechnology offers great potential in the field of nanomedicine for the treatment of various diseases, especially cancer. Graphene oxide nanoparticles have emerged as promising carbon-based nanocarriers for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and imaging. This review focuses on the biological functions of graphene oxide nanoparticles as regulators of apoptosis and autophagy, and their potential toxicity in major body organs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Kamila Buzun, Agnieszka Gornowicz, Roman Lesyk, Krzysztof Bielawski, Anna Bielawska
Summary: Autophagy is a self-degradation process that plays a crucial role in cell survival under stressful conditions. Recent research has focused on understanding the different types and mechanisms of autophagy, as well as the relationship between autophagy and apoptosis. Intensive studies have identified novel compounds with anticancer activity that can modulate autophagy pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Liqiang Zhou, Minfeng Huo, Xiaoqin Qian, Li Ding, Luodan Yu, Wei Feng, Xinwu Cui, Yu Chen
Summary: This study introduces a tumor therapeutic strategy using nanosonosensitizer-enhanced ultrasound-triggered sonodynamic therapy (SDT), which enhances the efficacy of SDT through autophagy inhibition and reduces cancer cell resistance to intracellular oxidative stress, achieving a significant synergistic effect.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sepideh Mirzaei, Mohammad Hossein Gholami, Amirhossein Zabolian, Hossein Saleki, Mahdi Vasheghani Farahani, Soodeh Hamzehlou, Fatemeh Bakhtiari Far, Seyed Omid Sharifzadeh, Saeed Samarghandian, Haroon Khan, Amir Reza Aref, Milad Ashrafizadeh, Ali Zarrabi, Gautam Sethi
Summary: Caffeic acid and caffeic acid phenethyl ester have anti-tumor activity and can impact cancer progression through multiple molecular pathways, as well as enhance the response of cancer cells to chemotherapy.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jiaxin Liang, Deyang Yu, Chi Luo, Christopher Bennett, Mark Jedrychowski, Steve P. Gygi, Hans R. Widlund, Pere Puigserver
Summary: This study reveals that the suppression of PGC1 alpha may define a subset of melanomas with resistance to BRAF inhibitors, and statins can be a potential treatment strategy for these melanomas.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Bin He, Wenkan Zhang, Jiaming He
Summary: The study demonstrated that fraxinellone (FRA) isolated from the D. dasycarpus plant inhibited the proliferation and migration of osteosarcoma cells, induced cell apoptosis, and increased autophagy flux. The pro-apoptotic effect of FRA was achieved through excessive autophagy flux, providing new ideas for future osteosarcoma treatment and offering theoretical support for the anti-cancer mechanism of FRA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Hiu Yeung Lau, Jingyi Tang, Patrick J. Casey, Mei Wang
Summary: The anchorage-independent soft-agar colony formation assay has been widely used as a bridge between adherent cell cultures and animal tumor studies to predict the tumorigenicity of cancer cells. However, the extraction of biological macromolecules from cells embedded in soft-agar matrices has been a challenge. New methods have been developed to extract DNA, RNA, and proteins directly from cells grown in soft agar, enabling molecular signaling analysis.
Article
Genetics & Heredity
Mohammad Sorowar Hossain, Md. Mahbub Hasan, Mary Petrou, Paul Telfer, Abdullah Al Mosabbir
Summary: This study was conducted at a dedicated thalassemia hospital in Dhaka, Bangladesh to investigate parental knowledge gaps and attitudes towards thalassemia. The findings revealed poor parental understanding of thalassemia including prenatal diagnosis and the challenges faced while caring for their children. These results are crucial for planning and implementing effective prevention and intervention strategies in Bangladesh and other countries with similar sociocultural settings.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Multidisciplinary Sciences
Md Abdullah Saeed Khan, Sourav Debnath, Md Shahnoor Islam, Susmita Zaman, Noor-E-Ambia, Anindita Das Barshan, Mohammad Sorowar Hossain, Tamanna Tabassum, Monjur Rahman, Mohammad Jahid Hasan
Summary: The study found that anxiety, depression, and stress were highly prevalent among young people not diagnosed with COVID-19 in Bangladesh, with unemployment being the most common underlying determinant.
Letter
Hematology
Mohammad Sorowar Hossain, Abdullah Al Mosabbir
Review
Biochemistry & Molecular Biology
Suhail Ahmed Kabeer Rasheed, Lalitha Vaishnavi Subramanyan, Wei Kiang Lim, Udhaya Kumari Udayappan, Mei Wang, Patrick J. Casey
Summary: G12 proteins, a subfamily of GTP-binding proteins, play important roles in human physiology by linking specific cell surface GPCRs to downstream signaling molecules. Studies have shown that increased expression and signaling of G alpha 12 and G alpha 13 are associated with tumorigenesis and tumor progression in multiple cancer types. Targeting G alpha 12/13 signaling may provide a new strategy to improve therapeutic outcomes in solid tumors.
Article
Infectious Diseases
Mohammad Sorowar Hossain, Robed Amin, Abdullah Al Mosabbir
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Biology
Jingyi Tang, Patrick J. Casey, Mei Wang
Summary: DNA damage has a dual impact on cancer cells: inducing genomic instability to promote cancer development while compromising proliferation and survival. Inhibiting ICMT reduces MAPK signaling activity, impairs DNA damage repair machinery, leading to cell cycle arrest and apoptosis in cancer cells. ICMT inhibition transforms cancer cells into a BRCA-like state, sensitizing them to PARP inhibitor and other DNA-damaging agents, particularly in anchorage-independent or in vivo conditions.
LIFE SCIENCE ALLIANCE
(2021)
Article
Multidisciplinary Sciences
Mohammad Sorowar Hossain, Md. Hasanul Banna Siam, Mohammad Nayeem Hasan, Rifat Jahan, Mahbubul H. Siddiqee
Summary: This study explores the knowledge, attitude, and practice regarding blood donation among students and teachers of religious academic institutions in Jamalpur district in Bangladesh. The majority of participants have never donated blood before, but many expressed a willingness to become regular donors. Lack of knowledge and opportunity were the main reasons for not donating blood, but participants overall have a positive attitude towards blood donation.
Article
Infectious Diseases
Jingli M. Yang, Abdullah Al Mosabbir, Enayetur M. Raheem, Wenbiao Hu, Mohammad Sorowar M. Hossain
Summary: Establishing reliable early warning models for severe dengue cases is important for triage and optimal resource utilization. This study assessed potential risk factors and their high-order combinative effects on severe dengue. Dyspnoea, plasma leakage, and hemorrhage were positively associated with severe dengue, and age was the most important predictor.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Behavioral Sciences
Mohammad Sorowar Hossain, Enayetur Raheem, Anthony D. Okely
Summary: This study examined the prevalence of obesity, physical activity, sedentary behavior, and sleep among young children in a district town in northern Bangladesh and identified factors associated with unhealthy weight status. The study found that 15% of children were overweight or obese, and only a portion of children met the guidelines for physical activity, sedentary behavior, and sleep. Maternal education, family income, and child's age were significantly associated with overweight/obesity.
BRAIN AND BEHAVIOR
(2023)
Review
Tropical Medicine
Mohammad Sorowar Hossain, Abdullah Al Noman, S. M. Abdullah Al Mamun, Abdullah Al Mosabbir
Summary: Dengue is a rapidly spreading mosquito-borne disease that poses a major public health threat, especially in tropical and subtropical countries like Bangladesh. This comprehensive review examines the overall situation of dengue in Bangladesh, including disease burden, clinical spectrum, seroprevalence, circulating serotypes/genotypes, and spatial distribution. Recent outbreaks have been associated with the emergence of serotype DENV-3, which had not been detected for a long time, leading to increased severity in clinical manifestation. The weak surveillance and risk management systems in Bangladesh are not adequately prepared to handle impending dengue risks.
TROPICAL MEDICINE AND HEALTH
(2023)
Article
Pediatrics
Ahsan Ahmed, Md Hasanul Banna, Mohammad Shojon, Md Mahdi Hasan, Enayetur Raheem, Mohammad Sorowar Hossain
Summary: This study explores the socio-demographic factors and circumstantial context of accidental poisoning in Bangladesh. The results reveal that preschool-aged children are more vulnerable to accidental poisoning, mainly caused by ingesting kerosene and insecticide/pesticide. Majority of the incidents occur in a nuclear family setting, with most cases taking place in the bedroom while parents are present at home.
BMJ PAEDIATRICS OPEN
(2022)
Letter
Tropical Medicine
Mohammad Sorowar Hossain
Summary: Human mobility, especially during festivals in rapidly growing megacities in low- and middle-income countries, has significant implications for infectious disease surveillance and response. This perspective highlights the case of Dhaka, the capital of Bangladesh, where three major disease outbreaks (chikungunya, dengue, and COVID-19) coincided with Muslim Eid festivals. Sharing this information is crucial for global efforts in combating emerging infectious diseases.
TROPICAL MEDICINE AND HEALTH
(2022)
Article
Medicine, Research & Experimental
Mohammad Sorowar Hossain, Iztiba M. Deeba, Mahmudul Hasan, Katharina E. Kariippanon, Kar Hau Chong, Penny L. Cross, Shameema Ferdous, Anthony D. Okely
Summary: Only a small proportion of children met the WHO guidelines, with the COVID-19 pandemic significantly impacting children's movement behaviors. However, the pilot study demonstrated the feasibility of the SUNRISE study in Bangladesh.
PILOT AND FEASIBILITY STUDIES
(2021)