Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

(2016) Lauren M. Sparks et al.   DIABETOLOGIA

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins

(2016) Michael N. Davies et al.   Cell Reports

Mitochondrial Quality Control and Muscle Mass Maintenance

(2016) Vanina Romanello et al.   Frontiers in Physiology

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

(2015) Satoshi Matsuzaki et al.   BIOCHEMISTRY

Resveratrol and obesity: Can resveratrol relieve metabolic disturbances?

(2015) Marlies de Ligt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling

(2015) Alison Ludzki et al.   DIABETES

Human Brown Adipose Tissue: What We Have Learned So Far

(2015) Matthias J. Betz et al.   DIABETES

Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery

(2015) Paul M. Coen et al.   DIABETES

Defects in Mitochondrial Efficiency and H2O2Emissions in Obese Women Are Restored to a Lean Phenotype With Aerobic Exercise Training

(2015) Adam R. Konopka et al.   DIABETES

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans

(2015) Mark J.W. Hanssen et al.   DIABETES

Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study

(2015) Joseph Henson et al.   DIABETES CARE

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Sarcolipin Is a Key Determinant of the Basal Metabolic Rate, and Its Overexpression Enhances Energy Expenditure and Resistance against Diet-induced Obesity

(2015) Santosh K. Maurya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

(2015) Javier Traba et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial reticulum for cellular energy distribution in muscle

(2015) Brian Glancy et al.   NATURE

The metabolic regulation of aging

(2015) Toren Finkel   NATURE MEDICINE

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

Mitochondria, Muscle Health, and Exercise with Advancing Age

(2015) Heather N. Carter et al.   PHYSIOLOGY

Adenine Nucleotide Translocase Is Acetylated in Vivo in Human Muscle: Modeling Predicts a Decreased ADP Affinity and Altered Control of Oxidative Phosphorylation

(2014) Clinton Mielke et al.   BIOCHEMISTRY

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes

(2014) Arun Baksi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Evidence for a Direct Effect of the NAD+Precursor Acipimox on Muscle Mitochondrial Function in Humans

(2014) Tineke van de Weijer et al.   DIABETES

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

(2014) D. A. Patten et al.   EMBO JOURNAL

Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance

(2014) Tomoyuki Watanabe et al.   EXPERIMENTAL CELL RESEARCH

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

(2014) Ciaran E. Fealy et al.   JOURNAL OF APPLIED PHYSIOLOGY

Long–echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

(2014) Lucas Lindeboom et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity and lipid stress inhibit carnitine acetyltransferase activity

(2014) Sarah E. Seiler et al.   JOURNAL OF LIPID RESEARCH

The mitochondrial unfolded protein response in mammalian physiology

(2014) Adrienne Mottis et al.   MAMMALIAN GENOME

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Circadian control of glucose metabolism

(2014) Andries Kalsbeek et al.   Molecular Metabolism

Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes

(2014) Darren C. Henstridge et al.   Molecular Metabolism

Insulin sensitivity and metabolic flexibility following exercise training among different obese insulin-resistant phenotypes

(2013) Steven K. Malin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

(2013) Silvie Timmers et al.   Annals of the New York Academy of Sciences

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Mitochondrial Autophagy

(2013) Robert L. Thomas et al.   CIRCULATION JOURNAL

Effect of Moderate-Intensity Exercise Versus Activities of Daily Living on 24-Hour Blood Glucose Homeostasis in Male Patients With Type 2 Diabetes

(2013) J.-W. van Dijk et al.   DIABETES CARE

The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging

(2013) Frederico G.S. Toledo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

(2013) Estelle Woldt et al.   NATURE MEDICINE

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner

(2012) Serge Summermatter et al.   DIABETES

What Do Magnetic Resonance-Based Measurements of Pi->ATP Flux Tell Us About Skeletal Muscle Metabolism?

(2012) G. J. Kemp et al.   DIABETES

Effect of exercise training on insulin sensitivity, mitochondria and computed tomography muscle attenuation in overweight women with and without polycystic ovary syndrome

(2012) S. K. Hutchison et al.   DIABETOLOGIA

Effect of contrasted levels of habitual physical activity on metabolic flexibility

(2012) Audrey Bergouignan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

(2012) Timothy R. Koves et al.   JOURNAL OF LIPID RESEARCH

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency

(2011) Robert Ringseis et al.   EUROPEAN JOURNAL OF NUTRITION

Mild heat stress induces mitochondrial biogenesis in C2C12 myotubes

(2011) Chien-Ting Liu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1α overexpressing mice

(2011) Joris Hoeks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Skeletal Muscle Mitochondrial Capacity and Insulin Resistance in Type 2 Diabetes

(2011) Sudip Bajpeyi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nine Days of Intensive Exercise Training Improves Mitochondrial Function But Not Insulin Action in Adult Offspring of Mothers with Type 2 Diabetes

(2011) Brian A. Irving et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults

(2011) MELANIE S. HOOD et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women

(2011) An Pan et al.   PLOS MEDICINE

Role of autophagy in diabetes and mitochondria

(2010) Hye Seung Jung et al.   Annals of the New York Academy of Sciences

Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1α or PGC-1β and mitofusin 2 in skeletal muscle in type 2 diabetes

(2010) Antonio Zorzano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats

(2010) Orsolya Marton et al.   BIOGERONTOLOGY

SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity

(2010) J. Rutanen et al.   DIABETES

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes

(2010) M. Hey-Mogensen et al.   DIABETOLOGIA

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity

(2010) Stephanie J. Mihalik et al.   Obesity

Overexpression of visfatin/PBEF/Nampt alters whole-body insulin sensitivity and lipid profile in rats

(2009) Qin Sun et al.   ANNALS OF MEDICINE

Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: Effects of exercise and aging

(2009) Vladimir Ljubicic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle

(2009) Hu Ding et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ShiftWork and Impaired Glucose Metabolism: A 14-Year Cohort Study on 7104 Male Workers

(2009) Yasushi Suwazono et al.   CHRONOBIOLOGY INTERNATIONAL

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans?

(2009) J.-F. Dumas et al.   DIABETES & METABOLISM

Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1 /Mitofusin-2 Regulatory Pathway in Response to Physical Activity

(2009) M. I. Hernandez-Alvarez et al.   DIABETES CARE

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Improvement of Insulin Sensitivity by a Novel Drug, BGP-15, in Insulin-resistant Patients: A Proof of Concept Randomized Double-blind Clinical Trial

(2009) B. Literáti-Nagy et al.   HORMONE AND METABOLIC RESEARCH

Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control

(2009) Robert C. Noland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria and diabetes mellitus: untangling a conflictive relationship?

(2009) M. Schiff et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Response of oxidative stress markers and antioxidant parameters to an 8-week aerobic physical activity program in healthy, postmenopausal women

(2008) Joanna Karolkiewicz et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

(2008) E. Phielix et al.   DIABETES

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

(2008) A. A. Gupte et al.   DIABETES

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice

(2008) Miranda Nabben et al.   FEBS LETTERS

Habitual physical activity in daily life correlates positively with markers for mitochondrial capacity

(2008) Marcel den Hoed et al.   JOURNAL OF APPLIED PHYSIOLOGY

Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals

(2008) D. E. Befroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paradoxical effects of increased expression of PGC-1  on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

(2008) C. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA