Article
Biochemistry & Molecular Biology
Jaime Gutierrez, David Gonzalez, Rodrigo Escalona-Rivano, Chiaki Takahashi, Enrique Brandan
Summary: RECK plays a role as a potential myogenic repressor during muscle formation and regeneration, with transient up-regulation accelerating muscle regeneration. RECK-deficient mice show reduced fibrosis in a model of chronic muscle damage, suggesting RECK as a potential target for treating muscle-wasting diseases.
Article
Sport Sciences
Harrison D. Stierwalt, Sarah E. Ehrlicher, Matthew M. Robinson, Sean A. Newsom
Summary: This study found that most ACSL protein isoforms can be detected in human skeletal muscle, with minimal changes in abundance after acute exercise. ACSL1 and ACSL6 are possible determinants of fat oxidation and fat storage within skeletal muscle, confirming findings from model systems.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Cell Biology
Seungyeon Yang, Sunsook Hwang, Byungjoo Kim, Seungmin Shin, Minjoong Kim, Seung Min Jeong
Summary: DNA repair is a crucial stress response mechanism that is vital for maintaining genome integrity following DNA damage. Recent studies have shown that metabolic pathways are involved in the cellular response to DNA damage. In this study, the researchers demonstrate that fatty acid oxidation (FAO) plays a key role in DNA double-strand break repair, particularly in homologous recombination repair. They found that FAO activates poly(ADP-ribose) polymerase 1 (PARP1), an enzyme involved in DNA repair, by promoting PARP1 acetylation with acetyl-CoA. Inhibition of FAO leads to reduced PARP1 activity, increased genomic instability, and decreased cell viability in response to DNA damage. This study highlights the importance of FAO in cellular response to DNA damage and its role in supporting DNA repair and genome stability.
CELL DEATH & DISEASE
(2023)
Article
Food Science & Technology
Aldo Leyva-Soto, Rocio Alejandra Chavez-Santoscoy, Omar Porras, Miltha Hidalgo-Ledesma, Aracely Serrano-Medina, Ana Alejandra Ramirez-Rodriguez, Nydia Alejandra Castillo-Martinez
Summary: Metabolic syndrome, a condition with increasing incidence globally, is associated with chronic diseases. A study showed that consuming enriched bread with a mixture of (-)-epicatechin and quercetin can improve biochemical parameters related to metabolic syndrome and decrease cell abnormalities in patients.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Huanyi Fu, Rongdiao Liu, Zixuan Jia, Ran Li, Feifeng Zhu, Wenxuan Zhu, Yangqing Shao, Yiyang Jin, Yuhua Xue, Jun Huang, Kunxin Luo, Xiang Gao, Huasong Lu, Qiang Zhou
Summary: DNA damage leads to transcriptional stalling to prevent mutagenesis and initiate repair signaling. Poly(ADP-ribose) polymerase (PARP1) inhibits Pol II elongation by inactivating the transcription elongation factor P-TEFb, promoting DNA repair and cell survival.
NATURE CELL BIOLOGY
(2022)
Article
Plant Sciences
Qiuting Yu, Ning Zhang, Xiaowen Gan, Linglin Chen, Rui Wang, Ronggan Liang, Jie Jian
Summary: This study demonstrated that EGCG attenuates myocardial ischemia injury by inhibiting ferroptosis. The study revealed the role of the miR-450b-5p/ACSL4 axis in acute myocardial infarction (AMI) and elucidated the molecular mechanisms of EGCG in inhibiting ferroptosis.
Article
Geriatrics & Gerontology
Shokoufeh Mahmoodzadeh, Katharina Koch, Cindy Schriever, Jingman Xu, Maria Steinecker, Joachim Leber, Elke Dworatzek, Bettina Purfuerst, Severine Kunz, Deborah Recchia, Monica Canepari, Arnd Heuser, Silvia Di Francescantonio, Ingo Morano
Summary: The study revealed that the Ahnak1 protein level increases with age in murine heart and muscle tissues. Suppression of Ahnak1 is associated with improved exercise tolerance, enhanced mitochondrial morphology and function, and a shift toward mitochondrial fusion balance. This suggests that Ahnak1 may play a role in age-related cardiac and skeletal muscle dysfunction and could be a potential therapeutic target.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Neurosciences
Maria H. H. Balch, Hallie Harris, Deepti Chugh, Surya Gnyawali, Cameron Rink, Shahid M. Nimjee, W. David Arnold
Summary: Research shows that ischemic stroke leads to neuromuscular junction pathology, including increased polyaxonal innervation. Robot-Assisted Mechanical massage Therapy can improve post-stroke neuromuscular junction alterations.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bernhard Andresen, Markus de Marees, Thorsten Schiffer, Wilhelm Bloch, Frank Suhr
Summary: Mechanosensors in human muscles show fiber type-specific distributions and their profiles are influenced by exercise intensities rather than environmental conditions.
Article
Medicine, Research & Experimental
Florent Porquet, Lin Weidong, Kevin Jehasse, Helene Gazon, Maria Kondili, Silvia Blacher, Laurent Massotte, Emmannuel Di Valentin, Denis Furling, Nicolas Albert Gillet, Arnaud Francois Klein, Vincent Seutin, Luc Willems
Summary: Myotonic dystrophy type 1 (DM1) is caused by the expansion of CTG microsatellites in the DMPK gene, leading to the expression of CUGexp transcripts. This results in the formation of toxic RNA aggregates that disrupt splicing factors, causing splicing misregulation. A new therapeutic approach using CRISPR interference to silence the DMPK promoter has been investigated, showing promising results in reducing DMPK transcripts and CUGexp-RNA aggregates in DM1 patient muscle cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biotechnology & Applied Microbiology
Debora Trichez, Andrei S. Steindorff, Wilson G. de Morais Junior, Nathalia Vilela, Jessica Carvalho Bergmann, Eduardo F. Formighieri, Silvia Belem Goncalves, Joao Ricardo Moreira de Almeida
Summary: Through evolutionary engineering, we successfully improved the co-fermentation capacity of two yeast strains for glucose and xylose utilization, and identified potential targets for further genetic engineering.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Haisen Huang, Shixing Ma, Xiaotao Xing, Xiaoxia Su, Xun Xu, Qi Tang, Xin Gao, Jian Yang, Maojiao Li, Cheng Liang, Yutao Wu, Li Liao, Weidong Tian
Summary: Osteoporosis is a prevalent bone disorder with reduced bone mass and increased fracture risk. Current treatments have unwanted side effects. This study developed cell-free therapy using extracellular vesicles (Mu-EVs) derived from skeletal muscles to treat disuse-induced osteoporosis. Mu-EVs promoted bone formation and suppressed bone resorption, showing potential for osteoporosis treatment.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Jiaping Chen, Yangwei Wang, Wangyang Meng, Rong Zhao, Wei Lin, Han Xiao, Yongde Liao
Summary: This study found that SCD1 promotes metastasis in lung cancer by maintaining the protein stability of beta-catenin and promoting CYP19A1 transcription to improve estrogen synthesis. SCD1 is a potential therapeutic target for non-small cell lung cancer (NSCLC), and its novel inhibitor, grape seed extract (GSE), has great therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Alexander M. Zero, Charles L. Rice
Summary: This study found that the post-activation potentiation (PAP) response in human muscle is similar regardless of different shortening velocities or contraction types. Despite differences in cross-bridge and Ca2+ kinetics, maximal contractions are likely to generate sufficient Ca2+ to induce a full PAP response, regardless of contraction modality.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Endocrinology & Metabolism
Sabina Paglialunga, Alison Ludzki, Jared Root-McCaig, Graham P. Holloway
Article
Endocrinology & Metabolism
Swati S. Jain, Sabina Paglialunga, Chris Vigna, Alison Ludzki, Eric A. Herbst, James S. Lally, Patrick Schrauwen, Joris Hoeks, A. Russ Tupling, Arend Bonen, Graham P. Holloway
Article
Endocrinology & Metabolism
Jenna B. Gillen, Michael E. Percival, Alison Ludzki, Mark A. Tarnopolsky, Martin. J. Gibala
Article
Neurosciences
James Roberts, James J. Burkitt, Bas Willemse, Alison Ludzki, James Lyons, Digby Elliott, Lawrence E. M. Grierson
EXPERIMENTAL BRAIN RESEARCH
(2013)
Article
Endocrinology & Metabolism
Benjamin J. Ryan, Michael W. Schleh, Cheehoon Ahn, Alison C. Ludzki, Jenna B. Gillen, Pallavi Varshney, Douglas W. Van Pelt, Lisa M. Pitchford, Thomas L. Chenevert, Rachel A. Gioscia-Ryan, Suzette M. Howton, Thomas Rode, Scott L. Hummel, Charles F. Burant, Jonathan P. Little, Jeffrey F. Horowitz
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Physiology
Benjamin J. Ryan, Katherine L. Foug, Rachel A. Gioscia-Ryan, Alison C. Ludzki, Cheehoon Ahn, Michael W. Schleh, Jenna B. Gillen, Thomas L. Chenevert, Jeffrey F. Horowitz
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Physiology
Benjamin J. Ryan, Katherine L. Foug, Rachel A. Gioscia-Ryan, Pallavi Varshney, Alison C. Ludzki, Cheehoon Ahn, Michael W. Schleh, Jenna B. Gillen, Thomas L. Chenevert, Jeffrey F. Horowitz
Summary: This study found that 12 weeks of moderate-intensity exercise or high-intensity interval training can reduce tissue iron storage in obese adults, including whole-body iron stores, hepatic iron content, and skeletal muscle ferritin abundance. These findings suggest important implications for obese individuals with dysregulated iron homeostasis.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Neurosciences
Cheehoon Ahn, Benjamin J. Ryan, Michael W. Schleh, Pallavi Varshney, Alison C. Ludzki, Jenna B. Gillen, Douglas W. Van Pelt, Lisa M. Pitchford, Suzette M. Howton, Thomas Rode, Scott L. Hummel, Charles F. Burant, Jonathan P. Little, Jeffrey F. Horowitz
Summary: Even without weight loss, 12 weeks of exercise training can alter adipose tissue structure and factors that regulate metabolism and the inflammatory signal pathway in adults with obesity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
Alastair G. Kerr, Zuoneng Wang, Na Wang, Kelvin H. M. Kwok, Jutta Jalkanen, Alison Ludzki, Simon Lecoutre, Dominique Langin, Martin O. Bergo, Ingrid Dahlman, Carsten Mim, Peter Arner, Hui Gao
Summary: The study identifies ADIPINT, a human adipocyte-specific lncRNA, as a regulator of lipid metabolism in white adipocytes. ADIPINT interacts with pyruvate carboxylase and affects its abundance and enzymatic activity, which in turn influences adipocyte lipid synthesis and breakdown. ADIPINT expression is increased in obesity and is associated with adipose insulin resistance and pyruvate carboxylase activity.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Alison C. Ludzki, Emily M. Krueger, Jenna B. Gillen, Natalie M. Taylor, Darby O. Middlebrook, Toree C. Baldwin, Konstantinos C. Karabetsos, Michael W. Schleh, Jeffrey F. Horowitz
Summary: The study assessed the response of nonobese adults to short-term overeating and found that a mild overeating stimulus can impair insulin sensitivity and upregulate genes related to abdominal adipose tissue storage capacity. There were no significant differences in response between exercisers and nonexercisers.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Michael W. W. Schleh, Benjamin J. J. Ryan, Cheehoon Ahn, Alison C. C. Ludzki, Pallavi Varshney, Jenna B. B. Gillen, Douglas W. W. Van Pelt, Lisa M. M. Pitchford, Suzette M. M. Howton, Thomas Rode, Thomas L. L. Chenevert, Scott L. L. Hummel, Charles F. F. Burant, Jeffrey F. F. Horowitz
Summary: The objective of this study was to assess the relationship between insulin-mediated glucose uptake and clinical outcomes, as well as deep-phenotyping measures. The study also aimed to examine how adipocyte size, fibrosis, and proteomic profile contribute to the regulation of fatty acid rate of appearance.