标题
Drug discovery in advanced prostate cancer: translating biology into therapy
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 15, Issue 10, Pages 699-718
出版商
Springer Nature
发表日期
2016-07-22
DOI
10.1038/nrd.2016.120
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- 776PA PHASE 1/2 STUDY OF AT13387, A HEAT SHOCK PROTEIN 90 (HSP90) INHIBITOR IN COMBINATION WITH ABIRATERONE ACETATE (AA) AND PREDNISONE (P) IN PATIENTS (PTS) WITH CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) NO LONGER RESPONDING TO AA
- (2017) R. Ferraldeschi et al. ANNALS OF ONCOLOGY
- Phase I trial of OGX-427, a 2'methoxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (Hsp27): Final results.
- (2017) S. J. Hotte et al. JOURNAL OF CLINICAL ONCOLOGY
- Results of a phase I/II clinical trial of BPX-101, a novel drug-activated dendritic cell (DC) vaccine for metastatic castration-resistant prostate cancer (mCRPC).
- (2017) G. Sonpavde et al. JOURNAL OF CLINICAL ONCOLOGY
- Pharmacodynamic activity demonstrated in phase I for PLX3397, a selective inhibitor of FMS and Kit.
- (2017) S. P. Anthony et al. JOURNAL OF CLINICAL ONCOLOGY
- Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells
- (2016) R. Ferraldeschi et al. CANCER RESEARCH
- Prostate cancer
- (2016) Gerhardt Attard et al. LANCET
- Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial
- (2015) J. Rodon et al. ANNALS OF ONCOLOGY
- Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
- (2015) Sarit Schwartz et al. CANCER CELL
- Abstract LB-056: TP53 and RB1 alterations promote reprogramming and antiandrogen resistance in advanced prostate cancer
- (2015) Ping Mu et al. CANCER RESEARCH
- Coordinate Loss of MAP3K7 and CHD1 Promotes Aggressive Prostate Cancer
- (2015) L. U. Rodrigues et al. CANCER RESEARCH
- A Unique Subset of Epithelial Ovarian Cancers with Platinum Sensitivity and PARP Inhibitor Resistance
- (2015) R. Ceccaldi et al. CANCER RESEARCH
- Integrative Clinical Genomics of Advanced Prostate Cancer
- (2015) Dan Robinson et al. CELL
- Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer
- (2015) A. A. Azad et al. CLINICAL CANCER RESEARCH
- Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells
- (2015) Wendy Onstenk et al. EUROPEAN UROLOGY
- Final analysis of a phase II study of Yale-modified FOLFIRINOX (mFOLFIRINOX) in metastatic pancreatic cancer (MPC).
- (2015) Edward Samuel James et al. JOURNAL OF CLINICAL ONCOLOGY
- Final analysis of COMET-1: Cabozantinib (Cabo) versus prednisone (Pred) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) previously treated with docetaxel (D) and abiraterone (A) and/or enzalutamide (E).
- (2015) Matthew Raymond Smith et al. JOURNAL OF CLINICAL ONCOLOGY
- Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
- (2015) Robert J. Motzer et al. JOURNAL OF CLINICAL ONCOLOGY
- Sequencing of agents in castration-resistant prostate cancer
- (2015) David Lorente et al. LANCET ONCOLOGY
- Abstract C45: Phase I study of WNT974, a first-in-class Porcupine inhibitor, in advanced solid tumors
- (2015) Filip Janku et al. MOLECULAR CANCER THERAPEUTICS
- Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer
- (2015) Zhenfei Li et al. NATURE
- Nivolumab in Previously Untreated Melanoma without BRAF Mutation
- (2015) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer
- (2015) Christopher J. Sweeney et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
- (2015) Joaquin Mateo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer
- (2015) Julie Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer
- (2015) Hossein Borghaei et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
- (2015) E. M. Van Allen et al. SCIENCE
- RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
- (2015) D. T. Miyamoto et al. SCIENCE
- Plasma AR and abiraterone-resistant prostate cancer
- (2015) Alessandro Romanel et al. Science Translational Medicine
- Immunotherapy for castration-resistant prostate cancer: Progress and new paradigms
- (2015) David I. Quinn et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Deubiquitinating enzymes as oncotargets
- (2015) Urszula L. McClurg et al. Oncotarget
- EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer
- (2015) Lucas J. Brand et al. Oncotarget
- Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer
- (2015) Michal Podrazil et al. Oncotarget
- Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel
- (2015) Pedram Kharaziha et al. Oncotarget
- Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer
- (2015) Emmanuel S. Antonarakis et al. JAMA Oncology
- Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins
- (2015) Paula Vainio et al. Oncotarget
- Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.
- (2015) Anastasia Wyce et al. Oncotarget
- Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer
- (2015) Francesco Crea et al. Oncotarget
- Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway
- (2015) Urszula L. McClurg et al. Oncotarget
- ASC-J9 Suppresses Castration-Resistant Prostate Cancer Growth through Degradation of Full-length and Splice Variant Androgen Receptors
- (2015) Shinichi Yamashita et al. NEOPLASIA
- Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer
- (2015) Juan Miguel Mosquera et al. NEOPLASIA
- Prioritizing targets for precision cancer medicine
- (2014) F. Andre et al. ANNALS OF ONCOLOGY
- Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression
- (2014) Luis Alberto Henríquez-Hernández et al. BMC Medical Genetics
- Novel drugs targeting the androgen receptor pathway in prostate cancer
- (2014) Joaquin Mateo et al. CANCER AND METASTASIS REVIEWS
- A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors
- (2014) E. Gabriela Chiorean et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Abstract 2433:In vitroandin vivoantitumor activity of the next generation HSP90 inhibitor, AT13387, in both hormone-sensitive and castration-resistant prostate cancer models.
- (2014) Roberta Ferraldeschi et al. CANCER RESEARCH
- Organoid Cultures Derived from Patients with Advanced Prostate Cancer
- (2014) Dong Gao et al. CELL
- Circulating Tumor Cells: A Multifunctional Biomarker
- (2014) T. A. Yap et al. CLINICAL CANCER RESEARCH
- Selectively Targeting the DNA-binding Domain of the Androgen Receptor as a Prospective Therapy for Prostate Cancer
- (2014) Kush Dalal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diagnostic and Treatment Dilemma of Dual Pathology of Lung Cancer and Disseminated Tuberculosis
- (2014) Nishitha Shetty et al. JOURNAL OF CLINICAL ONCOLOGY
- Strategies for modern biomarker and drug development in oncology
- (2014) Alan D Smith et al. Journal of Hematology & Oncology
- Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial
- (2014) Karim Fizazi et al. LANCET ONCOLOGY
- RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1
- (2014) John R Prensner et al. LANCET ONCOLOGY
- Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
- (2014) Eugene D Kwon et al. LANCET ONCOLOGY
- Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
- (2014) Diletta Di Mitri et al. NATURE
- Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
- (2014) Irfan A. Asangani et al. NATURE
- AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
- (2014) Emmanuel S. Antonarakis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects
- (2014) R Ferraldeschi et al. ONCOGENE
- Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer
- (2014) S. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Infiltration of CD8+ lymphocytes is an independent prognostic factor of biochemical failure-free survival in prostate cancer
- (2014) Nora Ness et al. PROSTATE
- Tumor clone dynamics in lethal prostate cancer
- (2014) S. Carreira et al. Science Translational Medicine
- Sustained Complete Response to CTLA-4 Blockade in a Patient with Metastatic, Castration-Resistant Prostate Cancer
- (2014) J. N. Graff et al. Cancer Immunology Research
- Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study
- (2013) S. F. Slovin et al. ANNALS OF ONCOLOGY
- Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer
- (2013) S. K. Sandhu et al. ANNALS OF ONCOLOGY
- Cancer statistics, 2013
- (2013) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma
- (2013) Markus Brockmann et al. CANCER CELL
- A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer
- (2013) Emmanuel S. Antonarakis et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- CHD1 Is a 5q21 Tumor Suppressor Required for ERG Rearrangement in Prostate Cancer
- (2013) L. Burkhardt et al. CANCER RESEARCH
- The Next-Generation Sequencing Revolution and Its Impact on Genomics
- (2013) Daniel C. Koboldt et al. CELL
- Punctuated Evolution of Prostate Cancer Genomes
- (2013) Sylvan C. Baca et al. CELL
- Molecular Pathways: Inhibiting Steroid Biosynthesis in Prostate Cancer
- (2013) R. Ferraldeschi et al. CLINICAL CANCER RESEARCH
- Phase II Study of Lutetium-177-Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer
- (2013) S. T. Tagawa et al. CLINICAL CANCER RESEARCH
- Targeting transcription factors
- (2013) Jennifer E. Yeh et al. CURRENT OPINION IN ONCOLOGY
- Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy
- (2013) Prabhakar Rajan et al. EUROPEAN UROLOGY
- An androgen receptor N-terminal domain antagonist for treating prostate cancer
- (2013) Jae-Kyung Myung et al. JOURNAL OF CLINICAL INVESTIGATION
- DNA Mismatch Repair in Prostate Cancer
- (2013) Himisha Beltran JOURNAL OF CLINICAL ONCOLOGY
- Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-Resistant Prostate Cancer
- (2013) Dana E. Rathkopf et al. JOURNAL OF CLINICAL ONCOLOGY
- Sex Difference in Myelodysplastic Syndrome Survival and Balance in Randomized Clinical Trials
- (2013) Tomas Radivoyevitch et al. JOURNAL OF CLINICAL ONCOLOGY
- Expanding Clinical Trial Networks in Pediatric Acute Lymphoblastic Leukemia
- (2013) Stephen P. Hunger JOURNAL OF CLINICAL ONCOLOGY
- Metabolomic Profiling Identifies Biochemical Pathways Associated with Castration-Resistant Prostate Cancer
- (2013) Akash K. Kaushik et al. JOURNAL OF PROTEOME RESEARCH
- N-terminal domain of the androgen receptor contains a region that can promote cytoplasmic localization
- (2013) Javid A. Dar et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Docetaxel and dasatinib or placebo in men with metastatic castration-resistant prostate cancer (READY): a randomised, double-blind phase 3 trial
- (2013) John C Araujo et al. LANCET ONCOLOGY
- Stable RNA interference rules for silencing
- (2013) Christof Fellmann et al. NATURE CELL BIOLOGY
- A preclinical xenograft model of prostate cancer using human tumors
- (2013) Mitchell G Lawrence et al. Nature Protocols
- Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
- (2013) Christoph Plass et al. NATURE REVIEWS GENETICS
- Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer
- (2013) Zhou Du et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer
- (2013) C. Parker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
- (2013) Sarah-Jane Dawson et al. NEW ENGLAND JOURNAL OF MEDICINE
- canSAR: updated cancer research and drug discovery knowledgebase
- (2013) Krishna C. Bulusu et al. NUCLEIC ACIDS RESEARCH
- Androgen receptors in hormone-dependent and castration-resistant prostate cancer
- (2013) Ayesha A. Shafi et al. PHARMACOLOGY & THERAPEUTICS
- Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation
- (2013) Lina Gao et al. PLoS One
- ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer
- (2013) A. Aytes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants
- (2013) Laura R. Bohrer et al. PROSTATE
- Peptidomimetic targeting of critical androgen receptor–coregulator interactions in prostate cancer
- (2013) Preethi Ravindranathan et al. Nature Communications
- Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
- (2013) Ellen Heitzer et al. Genome Medicine
- Randomized phase II study of danusertib in patients with metastatic castration-resistant prostate cancer after docetaxel failure
- (2012) Hielke J. Meulenbeld et al. BJU INTERNATIONAL
- Metastatic castrate-resistant prostate cancer: dawn of a new age of management
- (2012) Susan Masson et al. BJU INTERNATIONAL
- Sipuleucel-T immune parameters correlate with survival: an analysis of the randomized phase 3 clinical trials in men with castration-resistant prostate cancer
- (2012) Nadeem A. Sheikh et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
- (2012) N. J. Clegg et al. CANCER RESEARCH
- A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
- (2012) J. Waaler et al. CANCER RESEARCH
- Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines
- (2012) Y. Li et al. CANCER RESEARCH
- RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings
- (2012) Shancheng Ren et al. CELL RESEARCH
- Highly Specific Targeting of the TMPRSS2/ERG Fusion Gene Using Liposomal Nanovectors
- (2012) L. Shao et al. CLINICAL CANCER RESEARCH
- Phase II Trial of Weekly Ixabepilone in Men With Metastatic Castrate-Resistant Prostate Cancer (E3803): A Trial of the Eastern Cooperative Oncology Group
- (2012) Glenn Liu et al. Clinical Genitourinary Cancer
- Making the Most of Pathological Specimens: Molecular Diagnosis in Formalin-Fixed, Paraffin Embedded Tissue
- (2012) Jennifer A. Fairley et al. CURRENT DRUG TARGETS
- Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity
- (2012) Himisha Beltran et al. EUROPEAN UROLOGY
- Absolute Risk Prediction of Second Primary Thyroid Cancer Among 5-Year Survivors of Childhood Cancer
- (2012) Stephanie A. Kovalchik et al. JOURNAL OF CLINICAL ONCOLOGY
- Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study
- (2012) David Olmos et al. LANCET ONCOLOGY
- A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study
- (2012) Robert W Ross et al. LANCET ONCOLOGY
- Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial
- (2012) Christopher J Logothetis et al. LANCET ONCOLOGY
- CD4 helper T cells, CD8 cytotoxic T cells and FOXP3+ regulatory T cells with respect to lethal prostate cancer
- (2012) Sabina Davidsson et al. MODERN PATHOLOGY
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
- (2012) Christopher E Barbieri et al. NATURE GENETICS
- Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
- (2012) Jenna L. Riffell et al. NATURE REVIEWS DRUG DISCOVERY
- Objective assessment of cancer genes for drug discovery
- (2012) Mishal N. Patel et al. NATURE REVIEWS DRUG DISCOVERY
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
- (2012) Howard I. Scher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy
- (2012) Charles J. Ryan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines
- (2012) Raja Nhili et al. NUCLEIC ACIDS RESEARCH
- Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM
- (2012) Dejuan Kong et al. PLoS One
- Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex
- (2012) Zhijian Duan et al. PROSTATE
- EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
- (2012) K. Xu et al. SCIENCE
- Genome Sequencing Identifies a Basis for Everolimus Sensitivity
- (2012) G. Iyer et al. SCIENCE
- Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy
- (2012) S. R. Denmeade et al. Science Translational Medicine
- Dual Roles of PARP-1 Promote Cancer Growth and Progression
- (2012) M. J. Schiewer et al. Cancer Discovery
- Arachidonic Acid Pathway Members PLA2G7, HPGD, EPHX2, and CYP4F8 Identified as Putative Novel Therapeutic Targets in Prostate Cancer
- (2011) Paula Vainio et al. AMERICAN JOURNAL OF PATHOLOGY
- A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a
- (2011) K. N. Chi et al. ANNALS OF ONCOLOGY
- Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors
- (2011) Peter C. Hollenhorst et al. Annual Review of Biochemistry
- BAG-1 diversely affects steroid receptor activity
- (2011) Regina T. Knapp et al. BIOCHEMICAL JOURNAL
- Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
- (2011) Brett S. Carver et al. CANCER CELL
- Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer
- (2011) J. Chad Brenner et al. CANCER CELL
- A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors
- (2011) Gopa Iyer et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Androgen receptor and its splice variants in prostate cancer
- (2011) Simon Haile et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Circulating Tumor Cells as Biomarkers in Prostate Cancer
- (2011) D. C. Danila et al. CLINICAL CANCER RESEARCH
- A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer
- (2011) D. S. Hong et al. CLINICAL CANCER RESEARCH
- A Phase I Study of the Heat Shock Protein 90 Inhibitor Alvespimycin (17-DMAG) Given Intravenously to Patients with Advanced Solid Tumors
- (2011) Simon Pacey et al. CLINICAL CANCER RESEARCH
- Alternatively spliced androgen receptor variants
- (2011) Scott M Dehm et al. ENDOCRINE-RELATED CANCER
- Current and Emerging Treatment Options for Castration-Resistant Prostate Cancer: A Focus on Immunotherapy
- (2011) Winald R. Gerritsen et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Angiotensin Receptor Blockade and Risk of Cancer in Type 2 Diabetes Mellitus: A Nationwide Case-Control Study
- (2011) Chia-Hsuin Chang et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Randomized, Double-Blind, Placebo-Controlled Study of Tasquinimod in Men With Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer
- (2011) Roberto Pili et al. JOURNAL OF CLINICAL ONCOLOGY
- Androgen Receptor Rediscovered: The New Biology and Targeting the Androgen Receptor Therapeutically
- (2011) Charles J. Ryan et al. JOURNAL OF CLINICAL ONCOLOGY
- ERG gene rearrangements are common in prostatic small cell carcinomas
- (2011) Tamara L Lotan et al. MODERN PATHOLOGY
- The genomic complexity of primary human prostate cancer
- (2011) Michael F. Berger et al. NATURE
- Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
- (2011) Philip M Reaper et al. Nature Chemical Biology
- The changing therapeutic landscape of castration-resistant prostate cancer
- (2011) Timothy A. Yap et al. Nature Reviews Clinical Oncology
- Abiraterone and Increased Survival in Metastatic Prostate Cancer
- (2011) Johann S. de Bono et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer
- (2011) W Liu et al. ONCOGENE
- Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness
- (2011) S Huang et al. ONCOGENE
- MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors
- (2011) Nicola J. Clegg et al. PLoS One
- YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion
- (2011) Said Rahim et al. PLoS One
- Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival
- (2011) Emma Hörnberg et al. PLoS One
- Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers
- (2011) A. Kumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
- (2011) Rong Hu et al. PROSTATE
- Exploring the Genomes of Cancer Cells: Progress and Promise
- (2011) M. R. Stratton SCIENCE
- Therapeutic Targeting of SPINK1-Positive Prostate Cancer
- (2011) B. Ateeq et al. Science Translational Medicine
- Multicenter Phase II Trial of the Heat Shock Protein 90 Inhibitor, Retaspimycin Hydrochloride (IPI-504), in Patients With Castration-resistant Prostate Cancer
- (2011) William K. Oh et al. UROLOGY
- Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
- (2011) H. Beltran et al. Cancer Discovery
- Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer
- (2010) A H M Reid et al. BRITISH JOURNAL OF CANCER
- Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
- (2010) Raymond J. Andersen et al. CANCER CELL
- An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
- (2010) Jindan Yu et al. CANCER CELL
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- A randomized phase II trial of personalized peptide vaccine plus low dose estramustine phosphate (EMP) versus standard dose EMP in patients with castration resistant prostate cancer
- (2010) Masanori Noguchi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Exosomes as Biomarker Treasure Chests for Prostate Cancer
- (2010) Diederick Duijvesz et al. EUROPEAN UROLOGY
- Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors
- (2010) C. M. Robbins et al. GENOME RESEARCH
- Targeted high throughput sequencing of a cancer-related exome subset by specific sequence capture with a fully automated microarray platform
- (2010) Daniel Summerer et al. GENOMICS
- Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
- (2010) Philip W. Kantoff et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I Pharmacologic and Biologic Study of Ramucirumab (IMC-1121B), a Fully Human Immunoglobulin G1Monoclonal Antibody Targeting the Vascular Endothelial Growth Factor Receptor-2
- (2010) Jennifer L. Spratlin et al. JOURNAL OF CLINICAL ONCOLOGY
- Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
- (2010) Andrew Tutt et al. LANCET
- Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
- (2010) M William Audeh et al. LANCET
- Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
- (2010) Johann Sebastian de Bono et al. LANCET
- Translating cancer research into targeted therapeutics
- (2010) J. S. de Bono et al. NATURE
- Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
- (2010) Nallasivam Palanisamy et al. NATURE MEDICINE
- RNA sequencing: advances, challenges and opportunities
- (2010) Fatih Ozsolak et al. NATURE REVIEWS GENETICS
- Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
- (2010) Philip W. Kantoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Biases in Illumina transcriptome sequencing caused by random hexamer priming
- (2010) Kasper D. Hansen et al. NUCLEIC ACIDS RESEARCH
- Massively Parallel Sequencing: The Next Big Thing in Genetic Medicine
- (2009) Tracy Tucker et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors
- (2009) F Xu et al. CANCER GENE THERAPY
- Antitumor Activity with CYP17 Blockade Indicates That Castration-Resistant Prostate Cancer Frequently Remains Hormone Driven
- (2009) G. Attard et al. CANCER RESEARCH
- Characterization of ERG, AR and PTEN Gene Status in Circulating Tumor Cells from Patients with Castration-Resistant Prostate Cancer
- (2009) G. Attard et al. CANCER RESEARCH
- High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth
- (2009) K. Iljin et al. CLINICAL CANCER RESEARCH
- Targeted comparative genomic hybridization array for the detection of single- and multiexon gene deletions and duplications
- (2009) Marwan K Tayeh et al. GENETICS IN MEDICINE
- Systematic Structure-Function Analysis of Androgen Receptor Leu701Mutants Explains the Properties of the Prostate Cancer Mutant L701H
- (2009) Dennis J. van de Wijngaart et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective Inhibition of CYP17 With Abiraterone Acetate Is Highly Active in the Treatment of Castration-Resistant Prostate Cancer
- (2009) Gerhardt Attard et al. JOURNAL OF CLINICAL ONCOLOGY
- Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients
- (2009) Philippe O. Gannon et al. JOURNAL OF IMMUNOLOGICAL METHODS
- ETS rearrangements and prostate cancer initiation
- (2009) Brett S. Carver et al. NATURE
- Direct RNA sequencing
- (2009) Fatih Ozsolak et al. NATURE
- Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
- (2009) Arun Sreekumar et al. NATURE
- Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
- (2009) Brett S Carver et al. NATURE GENETICS
- A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
- (2009) Hayriye V Erkizan et al. NATURE MEDICINE
- Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes
- (2009) Iwanka Kozarewa et al. NATURE METHODS
- PSA as an intermediate end point in clinical trials
- (2009) Gerhardt Attard et al. Nature Reviews Urology
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells
- (2009) Y. Zong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel, spontaneously immortalized, human prostate cancer cell line, Bob, offers a unique model for pre-clinical prostate cancer studies
- (2009) Gerhardt Attard et al. PROSTATE
- Human prostate-infiltrating CD8+T lymphocytes are oligoclonal and PD-1+
- (2009) Karen S. Sfanos et al. PROSTATE
- Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
- (2009) C. Tran et al. SCIENCE
- Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer
- (2008) G Attard et al. BRITISH JOURNAL OF CANCER
- Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer
- (2008) Celestia S. Higano et al. CANCER
- The Role of SPINK1 in ETS Rearrangement-Negative Prostate Cancers
- (2008) Scott A. Tomlins et al. CANCER CELL
- Genomic Alterations Indicate Tumor Origin and Varied Metastatic Potential of Disseminated Cells from Prostate Cancer Patients
- (2008) I. N. Holcomb et al. CANCER RESEARCH
- Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance
- (2008) S. M. Dehm et al. CANCER RESEARCH
- A First-Generation Multiplex Biomarker Analysis of Urine for the Early Detection of Prostate Cancer
- (2008) B. Laxman et al. CANCER RESEARCH
- Hormone-sensitive prostate cancer: a case of ETS gene fusion heterogeneity
- (2008) G Attard et al. JOURNAL OF CLINICAL PATHOLOGY
- Dissecting prostate carcinogenesis through ETS gene rearrangement studies: implications for anticancer drug development
- (2008) G Attard et al. JOURNAL OF CLINICAL PATHOLOGY
- Next-generation DNA sequencing
- (2008) Jay Shendure et al. NATURE BIOTECHNOLOGY
- RNA-Seq: a revolutionary tool for transcriptomics
- (2008) Zhong Wang et al. NATURE REVIEWS GENETICS
- Substantial biases in ultra-short read data sets from high-throughput DNA sequencing
- (2008) J. C. Dohm et al. NUCLEIC ACIDS RESEARCH
- PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
- (2008) C A Crane et al. ONCOGENE
- CTLA-4 Control over Foxp3+ Regulatory T Cell Function
- (2008) K. Wing et al. SCIENCE
- Role of the TMPRSS2-ERG Gene Fusion in Prostate Cancer
- (2008) Scott A. Tomlins et al. NEOPLASIA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started