Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation
出版年份 2023 全文链接
标题
Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation
作者
关键词
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出版物
Frontiers in Molecular Biosciences
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2023-08-28
DOI
10.3389/fmolb.2023.1155753
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation
- (2023) Robert I. Horne et al. Journal of Chemical Theory and Computation
- Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers
- (2022) Thomas CT Michaels et al. JOURNAL OF CHEMICAL PHYSICS
- Trial of Prasinezumab in Early-Stage Parkinson’s Disease
- (2022) Gennaro Pagano et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trial of Cinpanemab in Early Parkinson’s Disease
- (2022) Anthony E. Lang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structures of α-synuclein filaments from human brains with Lewy pathology
- (2022) Yang Yang et al. NATURE
- Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates
- (2022) Sean Chia et al. Molecular Pharmaceutics
- The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
- (2021) Roberta Cascella et al. Nature Communications
- Parkinson disease-associated cognitive impairment
- (2021) Dag Aarsland et al. Nature Reviews Disease Primers
- Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
- (2020) Thomas C. T. Michaels et al. Nature Chemistry
- Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
- (2020) Sara Linse et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
- (2020) Thomas C. T. Michaels et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
- (2020) Roxine Staats et al. Communications Chemistry
- Parkinson disease
- (2019) R. Balestrino et al. EUROPEAN JOURNAL OF NEUROLOGY
- Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules
- (2018) Chia-Ju Hsieh et al. ACS Chemical Neuroscience
- Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
- (2018) Jordi Pujols et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
- (2018) Binsen Li et al. Nature Communications
- The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease
- (2018) Diana L. Price et al. Scientific Reports
- Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) E. Ray Dorsey et al. LANCET NEUROLOGY
- doGlycans–Tools for Preparing Carbohydrate Structures for Atomistic Simulations of Glycoproteins, Glycolipids, and Carbohydrate Polymers for GROMACS
- (2017) Reinis Danne et al. Journal of Chemical Information and Modeling
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
- (2017) Giuliana Fusco et al. SCIENCE
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Molecular mechanisms of protein aggregation from global fitting of kinetic models
- (2016) Georg Meisl et al. Nature Protocols
- Hamiltonian Dynamics of Protein Filament Formation
- (2016) Thomas C. T. Michaels et al. PHYSICAL REVIEW LETTERS
- Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
- (2016) Patrick Flagmeier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
- (2016) Céline Galvagnion et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity
- (2016) Giuliana Fusco et al. Scientific Reports
- Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
- (2015) Céline Galvagnion et al. Nature Chemical Biology
- Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation
- (2014) A. K. Buell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism
- (2013) S. I. A. Cohen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
- (2012) Nunilo Cremades et al. CELL
- The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
- (2012) Iryna Benilova et al. NATURE NEUROSCIENCE
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frequency Factors in a Landscape Model of Filamentous Protein Aggregation
- (2010) Alexander K. Buell et al. PHYSICAL REVIEW LETTERS
- Improved side-chain torsion potentials for the Amber ff99SB protein force field
- (2010) Kresten Lindorff-Larsen et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Fpocket: An open source platform for ligand pocket detection
- (2009) Vincent Le Guilloux et al. BMC BIOINFORMATICS
- AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
- (2009) Oleg Trott et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- An Analytical Solution to the Kinetics of Breakable Filament Assembly
- (2009) T. P. J. Knowles et al. SCIENCE
- P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation
- (2007) Berk Hess Journal of Chemical Theory and Computation
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