标题
The role of protein dynamics in the evolution of new enzyme function
作者
关键词
-
出版物
Nature Chemical Biology
Volume 12, Issue 11, Pages 944-950
出版商
Springer Nature
发表日期
2016-09-13
DOI
10.1038/nchembio.2175
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder
- (2015) Eynat Dellus-Gur et al. JOURNAL OF MOLECULAR BIOLOGY
- On the Challenge of Exploring the Evolutionary Trajectory from Phosphotriesterase to Arylesterase Using Computer Simulations
- (2015) Ram Prasad Bora et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD
- (2015) Susan K. Fetics et al. STRUCTURE
- Reverse evolution leads to genotypic incompatibility despite functional and active site convergence
- (2015) Miriam Kaltenbach et al. eLife
- Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins
- (2014) Sophie M.C. Gobeil et al. CHEMISTRY & BIOLOGY
- Evolutionary Aspects of Enzyme Dynamics
- (2014) Judith P. Klinman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis
- (2014) Adam T. Van Wart et al. Journal of Chemical Theory and Computation
- Dynamics and hydration explain failed functional transformation in dehalogenase design
- (2014) Jan Sykora et al. Nature Chemical Biology
- Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
- (2014) N. Preiswerk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein Conformational Populations and Functionally Relevant Substates
- (2013) Arvind Ramanathan et al. ACCOUNTS OF CHEMICAL RESEARCH
- Evolution of a designed retro-aldolase leads to complete active site remodeling
- (2013) Lars Giger et al. Nature Chemical Biology
- Automated identification of functional dynamic contact networks from X-ray crystallography
- (2013) Henry van den Bedem et al. NATURE METHODS
- Divergent evolution of protein conformational dynamics in dihydrofolate reductase
- (2013) Gira Bhabha et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The universality of enzymatic rate–temperature dependency
- (2013) Mikael Elias et al. TRENDS IN BIOCHEMICAL SCIENCES
- Sampling the Conformational Energy Landscape of a Hyperthermophilic Protein by Engineering Key Substitutions
- (2012) J.-P. Colletier et al. MOLECULAR BIOLOGY AND EVOLUTION
- Structure and dynamics of a primordial catalytic fold generated by in vitro evolution
- (2012) Fa-An Chao et al. Nature Chemical Biology
- Taking Ockham's razor to enzyme dynamics and catalysis
- (2012) David R. Glowacki et al. Nature Chemistry
- Topological analysis and interactive visualization of biological networks and protein structures
- (2012) Nadezhda T Doncheva et al. Nature Protocols
- Linking Crystallographic Model and Data Quality
- (2012) P. A. Karplus et al. SCIENCE
- Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
- (2012) Nobuhiko Tokuriki et al. Nature Communications
- Modelling dynamics in protein crystal structures by ensemble refinement
- (2012) B Tom Burnley et al. eLife
- ProDy: Protein Dynamics Inferred from Theory and Experiments
- (2011) A. Bakan et al. BIOINFORMATICS
- Definition and testing of the GROMOS force-field versions 54A7 and 54B7
- (2011) Nathan Schmid et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution
- (2011) Olga Khersonsky et al. JOURNAL OF MOLECULAR BIOLOGY
- Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme
- (2011) R. G. Silva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis
- (2011) G. Bhabha et al. SCIENCE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Mining electron density for functionally relevant protein polysterism in crystal structures
- (2010) James S. Fraser et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Hitting a moving target?—Understanding how conformational diversity impacts enzymatic catalysis
- (2010) Patrick J. O’Brien et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Enzyme dynamics point to stepwise conformational selection in catalysis
- (2010) Buyong Ma et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Modeling discrete heterogeneity in X-ray diffraction data by fitting multi-conformers
- (2009) Henry van den Bedem et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Hidden alternative structures of proline isomerase essential for catalysis
- (2009) James S. Fraser et al. NATURE
- Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
- (2009) C. J. Jackson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamical networks in tRNA:protein complexes
- (2009) A. Sethi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein Dynamism and Evolvability
- (2009) N. Tokuriki et al. SCIENCE
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- In Crystallo Capture of a Michaelis Complex and Product-binding Modes of a Bacterial Phosphotriesterase
- (2007) Colin J. Jackson et al. JOURNAL OF MOLECULAR BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now