Sampling the Conformational Energy Landscape of a Hyperthermophilic Protein by Engineering Key Substitutions

Direct Detection of Structurally Resolved Dynamics in a Multiconformation Receptor−Ligand Complex

(2011) Mary J. Carroll et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Evolution of Protein Conformational Changes Revealed by a Network of Evolutionarily Coupled Residues

(2011) Jouhyun Jeon et al.   MOLECULAR BIOLOGY AND EVOLUTION

Discovering Conformational Sub-States Relevant to Protein Function

(2011) Arvind Ramanathan et al.   PLoS One

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

(2011) Benoît Sanson et al.   PROTEIN SCIENCE

A Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature Activity

(2011) Sonia Y. Lam et al.   PLOS BIOLOGY

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Comparison of Family 9 Cellulases from Mesophilic and Thermophilic Bacteria

(2010) Florence Mingardon et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

In the light of directed evolution: Pathways of adaptive protein evolution

(2009) J. D. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

(2009) T. P. Schrank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

(2009) C. J. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A unified model of protein dynamics

(2009) H. Frauenfelder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

The pDynamo Program for Molecular Simulations using Hybrid Quantum Chemical and Molecular Mechanical Potentials

(2008) Martin J. Field   Journal of Chemical Theory and Computation

Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins

(2008) Shimon Bershtein et al.   JOURNAL OF MOLECULAR BIOLOGY