标题
Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
作者
关键词
-
出版物
Nature Communications
Volume 3, Issue 1, Pages -
出版商
Springer Nature
发表日期
2012-12-04
DOI
10.1038/ncomms2246
参考文献
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- (2012) Qiang Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Rise of Chemodiversity in Plants
- (2012) J.-K. Weng et al. SCIENCE
- Network Context and Selection in the Evolution to Enzyme Specificity
- (2012) H. Nam et al. SCIENCE
- The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters
- (2011) Arren Bar-Even et al. BIOCHEMISTRY
- Tradeoffs and Optimality in the Evolution of Gene Regulation
- (2011) Frank J. Poelwijk et al. CELL
- Strategy and success for the directed evolution of enzymes
- (2011) Paul A Dalby CURRENT OPINION IN STRUCTURAL BIOLOGY
- Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution
- (2011) Olga Khersonsky et al. JOURNAL OF MOLECULAR BIOLOGY
- Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population
- (2011) A. I. Khan et al. SCIENCE
- Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation
- (2011) H.-H. Chou et al. SCIENCE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
- (2010) Olga Khersonsky and Dan S. Tawfik Annual Review of Biochemistry
- What makes an enzyme promiscuous?
- (2010) Ann Babtie et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa
- (2010) R. C. MacLean et al. GENETICS
- Directed enzyme evolution: climbing fitness peaks one amino acid at a time
- (2009) Cara A Tracewell et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Stability effects of mutations and protein evolvability
- (2009) Nobuhiko Tokuriki et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Chaperonin overexpression promotes genetic variation and enzyme evolution
- (2009) Nobuhiko Tokuriki et al. NATURE
- Exploring protein fitness landscapes by directed evolution
- (2009) Philip A. Romero et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- In the light of directed evolution: Pathways of adaptive protein evolution
- (2009) J. D. Bloom et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
- (2009) C. J. Jackson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein Dynamism and Evolvability
- (2009) N. Tokuriki et al. SCIENCE
- Near Neutrality
- (2008) Austin L. Hughes Annals of the New York Academy of Sciences
- Evolutionary History of a Specialized P450 Propane Monooxygenase
- (2008) Rudi Fasan et al. JOURNAL OF MOLECULAR BIOLOGY
- Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
- (2008) Paul E O'Maille et al. Nature Chemical Biology
- Functional plasticity of paralogous diterpene synthases involved in conifer defense
- (2008) C. I. Keeling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- How Protein Stability and New Functions Trade Off
- (2008) Nobuhiko Tokuriki et al. PLoS Computational Biology
- In Crystallo Capture of a Michaelis Complex and Product-binding Modes of a Bacterial Phosphotriesterase
- (2007) Colin J. Jackson et al. JOURNAL OF MOLECULAR BIOLOGY
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