Proteomic Analyses of the G Protein-Coupled Estrogen Receptor GPER1 Reveal Constitutive Links to Endoplasmic Reticulum, Glycosylation, Trafficking, and Calcium Signaling

The G protein-coupled oestrogen receptor GPER in health and disease: an update

(2023) Eric R. Prossnitz et al.   Nature Reviews Endocrinology

Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

(2023) Paul Sohn et al.   DIABETES

Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation

(2022) Sang Kwon Lee et al.   Cell Reports

Clptm1, a new target in suppressing epileptic seizure by regulating GABA A R ‐mediated inhibitory synaptic transmission in a PTZ ‐induced epilepsy model

(2022) Xiao‐Lin Zhang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Multiplex G Protein–Coupled Receptor Screen Reveals Reliably Acting Agonists and a Gq-Phospholipase C Coupling Mode of GPR30/GPER1

(2022) Nicole Urban et al.   MOLECULAR PHARMACOLOGY

Ligand-Independent G Protein–Coupled Estrogen Receptor/G Protein–Coupled Receptor 30 Activity: Lack of Receptor-Dependent Effects of G-1 and 17β-Estradiol

(2021) Julia Tutzauer et al.   MOLECULAR PHARMACOLOGY

A review of the functions of G protein-coupled estrogen receptor 1 in vascular and neurological aging

(2021) Shaojie Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

(2021) Amado Carreras-Sureda et al.   eLife

Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function

(2020) Milad Rouhimoghadam et al.   Frontiers in Endocrinology

Human G protein-coupled receptor 30 is N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity

(2019) Ernesto Gonzalez de Valdivia et al.   BIOSCIENCE REPORTS

PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway

(2019) Gu-Choul Shin et al.   Nature Communications

Discovery of proteins associated with a predefined genomic locus via dCas9–APEX-mediated proximity labeling

(2018) Samuel A. Myers et al.   NATURE METHODS

Clptm1 Limits Forward Trafficking of GABA A Receptors to Scale Inhibitory Synaptic Strength

(2018) Yuan Ge et al.   NEURON

Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm

(2018) Nupura Hirve et al.   Cell Reports

Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer

(2018) Florian Meier et al.   MOLECULAR & CELLULAR PROTEOMICS

Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization

(2017) Ismail Sergin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells

(2017) Marco Pupo et al.   Oncotarget

Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

(2017) Pornchai Kaewsapsak et al.   eLife

Assessment of cell line competence for studies of pharmacological GPR30 modulation

(2016) Cátia Sousa et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2

(2016) Victoria Hung et al.   Nature Protocols

Interaction mode between catalytic and regulatory subunits in glucosidase II involved in ER glycoprotein quality control

(2016) Tadashi Satoh et al.   PROTEIN SCIENCE

The STIM1–ORAI1 microdomain

(2015) Patrick G Hogan   CELL CALCIUM

Hetero-oligomeric Complex between the G Protein-coupled Estrogen Receptor 1 and the Plasma Membrane Ca2+-ATPase 4b

(2015) Quang-Kim Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

G protein-coupled Receptor 30 (GPR30) Forms a Plasma Membrane Complex with Membrane-associated Guanylate Kinases (MAGUKs) and Protein Kinase A-anchoring Protein 5 (AKAP5) That Constitutively Inhibits cAMP Production

(2014) Stefan Broselid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection

(2013) Patricia M Lenhart et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data

(2012) Juergen Cox et al.   BMC BIOINFORMATICS

Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts

(2012) Marco Pupo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Network-based Approach for Predicting Missing Pathway Interactions

(2012) Saket Navlakha et al.   PLoS Computational Biology

Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

(2011) Joanne Oates et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity

(2011) Megan K. Dennis et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Nuclear Alternate Estrogen Receptor GPR30 Mediates 17 -Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts

(2010) A. Madeo et al.   CANCER RESEARCH

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Involvement of Estrogen Receptor Variant ER-α36, Not GPR30, in Nongenomic Estrogen Signaling

(2010) Lianguo Kang et al.   MOLECULAR ENDOCRINOLOGY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Discovering pathways by orienting edges in protein interaction networks

(2010) Anthony Gitter et al.   NUCLEIC ACIDS RESEARCH

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

(2009) Deo Prakash Pandey et al.   EMBO JOURNAL

PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation

(2009) Hongyu Gao et al.   HUMAN MOLECULAR GENETICS

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo effects of a GPR30 antagonist

(2009) Megan K Dennis et al.   Nature Chemical Biology

G Protein-Coupled Receptor 30 Localizes to the Endoplasmic Reticulum and Is Not Activated by Estradiol

(2008) Christiane Otto et al.   ENDOCRINOLOGY

Epidermal Growth Factor Induces G Protein-Coupled Receptor 30 Expression in Estrogen Receptor-Negative Breast Cancer Cells

(2008) Lidia Albanito et al.   ENDOCRINOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

(2008) Jonathan Stiber et al.   NATURE CELL BIOLOGY