S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

S-acylation of Orai1 regulates store-operated Ca2+ entry

(2021) Savannah J. West et al.   JOURNAL OF CELL SCIENCE

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

(2020) Xiaowei Hou et al.   eLife

Structural features of STIM and Orai underlying store-operated calcium entry

(2019) Ruoyi Qiu et al.   CURRENT OPINION IN CELL BIOLOGY

Imaging the Human Immunological Synapse

(2019) Ana Bello-Gamboa et al.   Jove-Journal of Visualized Experiments

Cross-linking of Orai1 channels by STIM proteins

(2018) Yandong Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures reveal opening of the store-operated calcium channel Orai

(2018) Xiaowei Hou et al.   eLife

Protein palmitoylation: Palmitoyltransferases and their specificity

(2017) Sabina Tabaczar et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Identification of PSD-95 Depalmitoylating Enzymes

(2016) Norihiko Yokoi et al.   JOURNAL OF NEUROSCIENCE

Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

(2016) Catherine A Hartzell et al.   eLife

Thiol dependent intramolecular locking of Orai1 channels

(2016) Dalia Alansary et al.   Scientific Reports

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca2+ influx levels

(2015) R. Hodeify et al.   JOURNAL OF CELL SCIENCE

Quantitative analysis of the human T cell palmitome

(2015) Eliot Morrison et al.   Scientific Reports

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum–plasma membrane junctions

(2014) Minnie M. Wu et al.   MOLECULAR BIOLOGY OF THE CELL

STIM1 Juxtaposes ER to Phagosomes, Generating Ca2+ Hotspots that Boost Phagocytosis

(2012) Paula Nunes et al.   CURRENT BIOLOGY

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

Gated regulation of CRAC channel ion selectivity by STIM1

(2012) Beth A. McNally et al.   NATURE

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

(2012) Erdinc Sezgin et al.   Nature Protocols

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution

(2012) Dylan M. Owen et al.   Nature Communications

Proteomic analysis of palmitoylated platelet proteins

(2011) L. Dowal et al.   BLOOD

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation

(2011) Ariel Quintana et al.   EMBO JOURNAL

DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells

(2011) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion Channel Regulation by Protein Palmitoylation

(2011) Michael J. Shipston   JOURNAL OF BIOLOGICAL CHEMISTRY

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

T Cell Signal Regulation by the Actin Cytoskeleton

(2010) Gurunadh R. Chichili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling

(2010) I. Bogeski et al.   Science Signaling

Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

(2009) Tobias Zech et al.   EMBO JOURNAL

Formation of STIM and Orai complexes: puncta and distal caps

(2009) Valarie A. Barr et al.   IMMUNOLOGICAL REVIEWS

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

(2009) N. Scrimgeour et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps

(2008) Valarie A. Barr et al.   MOLECULAR BIOLOGY OF THE CELL

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation

(2008) M. I. Lioudyno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA