标题
Therapeutic targeting of ALS pathways: Refocusing an incomplete picture
作者
关键词
-
出版物
Annals of Clinical and Translational Neurology
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2023-08-29
DOI
10.1002/acn3.51887
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Skeletal muscle in amyotrophic lateral sclerosis
- (2023) Jeremy M Shefner et al. BRAIN
- SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function
- (2023) Mukesh Gautam et al. NEUROBIOLOGY OF DISEASE
- Phase 2B randomized controlled trial of NP001 in amyotrophic lateral sclerosis: pre‐specified and post‐hoc analyses
- (2022) Robert G. Miller et al. MUSCLE & NERVE
- Exploring Motor Neuron Diseases Using iPSC Platforms
- (2022) Alexandra E Johns et al. STEM CELLS
- Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis
- (2022) Simon Witzel et al. JAMA Neurology
- Survival analyses from the CENTAUR trial in amyotrophic lateral sclerosis: Evaluating the impact of treatment crossover on outcomes
- (2022) Sabrina Paganoni et al. MUSCLE & NERVE
- Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis
- (2022) Ryosuke Oki et al. JAMA Neurology
- Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
- (2022) Timothy M. Miller et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of PB‐TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblasts
- (2022) Jasmine A. Fels et al. Annals of Clinical and Translational Neurology
- Overview of stem cells therapy in amyotrophic lateral sclerosis
- (2021) Goun Je et al. NEUROLOGICAL RESEARCH
- A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis
- (2021) Lauren Mifflin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy and ALS: mechanistic insights and therapeutic implications
- (2021) Jason P. Chua et al. Autophagy
- Tocilizumab is safe and tolerable and reduces C ‐reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients
- (2021) Carol Milligan et al. MUSCLE & NERVE
- Safety and efficacy of dimethyl fumarate in ALS: randomised controlled study
- (2021) Steve Vucic et al. Annals of Clinical and Translational Neurology
- Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives
- (2021) Tiziana Bonifacino et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A randomized placebo‐controlled phase 3 study of mesenchymal stem cells induced to secrete high levels of neurotrophic factors in amyotrophic lateral sclerosis
- (2021) Merit E. Cudkowicz et al. MUSCLE & NERVE
- Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy
- (2020) Yanming Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tamoxifen for amyotrophic lateral sclerosis
- (2020) Po-Chih Chen et al. MEDICINE
- Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
- (2020) Timothy Miller et al. NEW ENGLAND JOURNAL OF MEDICINE
- Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis
- (2020) Jinsy A. Andrews et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis
- (2020) Sabrina Paganoni et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS
- (2020) Jeremy M. Shefner et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Assessment of Use and Safety of Edaravone for Amyotrophic Lateral Sclerosis in the Veterans Affairs Health Care System
- (2020) Michelle Vu et al. JAMA Network Open
- Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial
- (2020) Michael D. Weiss et al. MUSCLE & NERVE
- Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis
- (2020) Brian J. Wainger et al. JAMA Neurology
- Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis
- (2020) HaEun Cho et al. Pharmaceuticals
- A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis
- (2019) Jeremy M. Shefner et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial
- (2019) Jesus S. Mora et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- NurOwn, phase 2, randomized, clinical trial in patients with ALS
- (2019) James D. Berry et al. NEUROLOGY
- Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis
- (2019) Suma Babu et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis – Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial)
- (2019) Satoru Morimoto et al. Regenerative Therapy
- Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models
- (2018) Alex McCampbell et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapamycin treatment for amyotrophic lateral sclerosis
- (2018) Jessica Mandrioli et al. MEDICINE
- Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressiveSOD1ALS
- (2018) Michael Benatar et al. NEUROLOGY
- Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis
- (2018) Gretchen M. Thomsen et al. STEM CELLS
- Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis
- (2018) Ki-Wook Oh et al. ANNALS OF NEUROLOGY
- Protein production is an early biomarker for RNA ‐targeted therapies
- (2018) Wade K. Self et al. Annals of Clinical and Translational Neurology
- Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability
- (2017) James D. Berry et al. MUSCLE & NERVE
- Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
- (2017) Lindsay A. Becker et al. NATURE
- Methylcobalamin prevents mutant superoxide dismutase-1-induced motor neuron death in vitro
- (2017) Shunsuke Ito et al. NEUROREPORT
- Open label study to assess the safety of VM202 in subjects with amyotrophic lateral sclerosis
- (2017) Robert L. Sufit et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Riluzole does not improve lifespan or motor function in three ALS mouse models
- (2017) Marion C. Hogg et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity
- (2016) Valeria Crippa et al. HUMAN MOLECULAR GENETICS
- Transplantation of spinal cord–derived neural stem cells for ALS
- (2016) Jonathan D. Glass et al. NEUROLOGY
- A randomized trial of mexiletine in ALS
- (2016) Michael D. Weiss et al. NEUROLOGY
- A randomized, placebo-controlled, double-blind phase IIb trial evaluating the safety and efficacy of tirasemtiv in patients with amyotrophic lateral sclerosis
- (2016) Jeremy M. Shefner et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Neural and glial progenitor transplantation as a neuroprotective strategy for Amyotrophic Lateral Sclerosis (ALS)
- (2015) Amanda M. Haidet-Phillips et al. BRAIN RESEARCH
- The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis
- (2015) P.S. Kolb et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- In vivo kinetic approach reveals slow SOD1 turnover in the CNS
- (2015) Matthew J. Crisp et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapamycin alleviates pathogenesis of a newDrosophilamodel of ALS-TDP
- (2015) Ching-Wei Cheng et al. JOURNAL OF NEUROGENETICS
- Neuroprotective effect of ultra-high dose methylcobalamin in wobbler mouse model of amyotrophic lateral sclerosis
- (2015) Ken Ikeda et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse
- (2015) Ken Ikeda et al. PLoS One
- A single blind randomized controlled clinical trial of mexiletine in amyotrophic lateral sclerosis: Efficacy and safety of sodium channel blocker phase II trial
- (2015) Kazumoto Shibuya et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Lithium and Autophagy
- (2014) Yumiko Motoi et al. ACS Chemical Neuroscience
- Global Gene Expression Profiling in R155H Knock-In Murine Model of VCP Disease
- (2014) Angèle Nalbandian et al. CTS-Clinical and Translational Science
- A phase II−III trial of olesoxime in subjects with amyotrophic lateral sclerosis
- (2014) T. Lenglet et al. EUROPEAN JOURNAL OF NEUROLOGY
- Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD
- (2014) Serena Lattante et al. HUMAN MOLECULAR GENETICS
- Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis
- (2014) V. Bros-Facer et al. HUMAN MOLECULAR GENETICS
- Evidence for peripheral immune activation in amyotrophic lateral sclerosis
- (2014) Xueping Chen et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis
- (2014) Lijun Wang et al. NEUROBIOLOGY OF DISEASE
- Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
- (2014) H.-Q. Jiang et al. NEUROSCIENCE
- Safety, Pharmacokinetic, and Functional Effects of the Nogo-A Monoclonal Antibody in Amyotrophic Lateral Sclerosis: A Randomized, First-In-Human Clinical Trial
- (2014) Vincent Meininger et al. PLoS One
- Fast Skeletal Muscle Troponin Activator tirasemtiv Increases Muscle Function and Performance in the B6SJL-SOD1G93A ALS Mouse Model
- (2014) Darren T. Hwee et al. PLoS One
- Dexpramipexole Is Ineffective in Two Models of ALS Related Neurodegeneration
- (2014) Fernando G. Vieira et al. PLoS One
- Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons
- (2014) Brian J. Wainger et al. Cell Reports
- NP001 regulation of macrophage activation markers in ALS: A phase I clinical and biomarker study
- (2014) Robert G. Miller et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients
- (2014) Koji Abe et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis
- (2014) S. Deivasigamani et al. Biology Open
- Fingolimod phosphate promotes the neuroprotective effects of microglia
- (2013) Hiromi Noda et al. JOURNAL OF NEUROIMMUNOLOGY
- Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability
- (2013) Elsa Fritz et al. JOURNAL OF NEUROPHYSIOLOGY
- RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
- (2013) Christopher J. Donnelly et al. NEURON
- Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats
- (2013) Geneviève Gowing et al. NEUROREPORT
- Valproic acid pathway
- (2013) Yogita Ghodke-Puranik et al. Pharmacogenetics and Genomics
- Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
- (2013) C. Lagier-Tourenne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
- (2013) D. Sareen et al. Science Translational Medicine
- A study to evaluate safety and tolerability of repeated doses of tirasemtiv in patients with amyotrophic lateral sclerosis
- (2013) Jeremy M. Shefner et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Treatment with a coinducer of the heat shock response delays muscle denervation in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
- (2012) Bernadett Kalmar et al. Amyotrophic Lateral Sclerosis
- Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
- (2012) Alan J Russell et al. NATURE MEDICINE
- A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis
- (2012) Luc Dupuis et al. PLoS One
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
- (2012) I.-F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients
- (2012) Jonathan D. Glass et al. STEM CELLS
- Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger
- (2011) Masashi Aoki et al. BRAIN RESEARCH
- The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis
- (2011) Merit Cudkowicz et al. NATURE MEDICINE
- Translational stem cell therapy for amyotrophic lateral sclerosis
- (2011) Nicholas M. Boulis et al. Nature Reviews Neurology
- Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: Examining a more efficient trial design
- (2011) R. G. Miller et al. NEUROLOGY
- A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis
- (2010) Mamede de Carvalho et al. Amyotrophic Lateral Sclerosis
- The Fast Skeletal Troponin Activator, CK-1909178 Reduces Muscle Fatigue in a Model of Peripheral Artery Disease in Situ
- (2010) Aaron Hinken et al. BIOPHYSICAL JOURNAL
- Calcium dysregulation in amyotrophic lateral sclerosis
- (2010) Julian Grosskreutz et al. CELL CALCIUM
- Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model
- (2010) Kiyoshi Okada et al. EXPERIMENTAL NEUROLOGY
- Lithium carbonate in amyotrophic lateral sclerosis: Lack of efficacy in a dose-finding trial
- (2010) A. Chio et al. NEUROLOGY
- Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells
- (2010) Jesse C. Wiley et al. PLoS One
- A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis
- (2009) Robert M. Pascuzzi et al. Amyotrophic Lateral Sclerosis
- Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis
- (2009) Sanne Piepers et al. ANNALS OF NEUROLOGY
- A soluble activin type IIB receptor improves function in a mouse model of amyotrophic lateral sclerosis
- (2009) Brett M. Morrison et al. EXPERIMENTAL NEUROLOGY
- Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases
- (2009) Ofer Sadan et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Autophagy, lithium, and amyotrophic lateral sclerosis
- (2009) Livia Pasquali et al. MUSCLE & NERVE
- Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT
- (2009) Patrice Dubreuil et al. PLoS One
- A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease
- (2008) Richard W. Orrell et al. Amyotrophic Lateral Sclerosis
- R(+) pramipexole as a mitochondrially focused neuroprotectant: Initial early phase studies in ALS
- (2008) Hua Wang et al. Amyotrophic Lateral Sclerosis
- Descending Pathways in Motor Control
- (2008) Roger N. Lemon Annual Review of Neuroscience
- Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
- (2008) Hidefumi Ito et al. EXPERIMENTAL NEUROLOGY
- Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis
- (2008) Massimo Pieri et al. EXPERIMENTAL NEUROLOGY
- Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity
- (2008) James C Dodge et al. MOLECULAR THERAPY
- Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis
- (2008) Merit E. Cudkowicz et al. MUSCLE & NERVE
- Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis
- (2008) A. Vercelli et al. NEUROBIOLOGY OF DISEASE
- Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis
- (2008) S. Zoccolella et al. NEUROLOGY
- Subcutaneous IGF-1 is not beneficial in 2-year ALS trial
- (2008) E. J. Sorenson et al. NEUROLOGY
- Lithium delays progression of amyotrophic lateral sclerosis
- (2008) F. Fornai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started