Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney

Metformin for Treatment of Acute COVID-19: Systematic Review of Clinical Trial Data Against SARS-CoV-2

(2023) Spencer M. Erickson et al.   DIABETES CARE

Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial

(2023) Carolyn T Bramante et al.   LANCET INFECTIOUS DISEASES

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

(2022) Teng Ma et al.   NATURE

Metabolomics study of COVID-19 patients in four different clinical stages

(2022) Alberto Valdés et al.   Scientific Reports

Protection by metformin against severe Covid-19: an in-depth mechanistic analysis

(2022) Nicolas Wiernsperger et al.   DIABETES & METABOLISM

The immunology and immunopathology of COVID-19

(2022) Miriam Merad et al.   SCIENCE

Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway

(2022) Marta Sanz-Gómez et al.   Scientific Reports

Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway

(2022) Hui Wang et al.   PHARMACEUTICAL BIOLOGY

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

(2021) Rogan A. Grant et al.   NATURE

COVID-19: A Mitochondrial Perspective

(2021) Pankaj Prasun   DNA AND CELL BIOLOGY

Host metabolic reprogramming in response to SARS-CoV-2 infection: A systems biology approach

(2021) S.T.R. Moolamalla et al.   MICROBIAL PATHOGENESIS

Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

(2021) Jihoon W. Lee et al.   NATURE BIOTECHNOLOGY

Decreased Fatty Acid Oxidation and Altered Lactate Production during Exercise in Patients with Post-acute COVID-19 Syndrome

(2021) Esther de Boer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

(2021) Jitske Jansen et al.   Cell Stem Cell

Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome

(2021) Ivayla Roberts et al.   Metabolomics

Mechanisms of SARS-CoV-2 entry into cells

(2021) Cody B. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies

(2020) Sufang Tian et al.   MODERN PATHOLOGY

Severe Covid-19

(2020) David A. Berlin et al.   NEW ENGLAND JOURNAL OF MEDICINE

How does SARS-CoV-2 cause COVID-19?

(2020) Nicholas J. Matheson et al.   SCIENCE

The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury

(2020) Lara Console et al.   Frontiers in Physiology

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

(2020) Tiffany Thomas et al.   JCI Insight

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

(2020) Ildefonso Sánchez-Cerrillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

(2019) Vahid Kheirollahi et al.   Nature Communications

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

The effect of human adipose-derived stem cells on lipopolysaccharide-induced acute respiratory distress syndrome in mice

(2019) Young Ju Jung et al.   Annals of Translational Medicine

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

(2018) Jianye Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury

(2018) Huachun Cui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

(2018) Paula Saz-Leal et al.   Cell Reports

Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

(2017) Ana L. Mora et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute Respiratory Distress Syndrome

(2017) B. Taylor Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defining the effects of storage on platelet bioenergetics: The role of increased proton leak

(2015) Saranya Ravi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

(2009) Robert L. Chevalier et al.   KIDNEY INTERNATIONAL