Segmented, Negative-Sense RNA Viruses of Humans: Genetic Systems and Experimental Uses of Reporter Strains

A small stem-loop-forming region within the 3′-UTR of a nonpolyadenylated LCMV mRNA promotes translation

(2022) Mei Hashizume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of a pdmH1N1 2018 Influenza A Reporter Virus Carrying a mCherry Fluorescent Protein in the PA Segment

(2022) Ling Bu et al.   Frontiers in Cellular and Infection Microbiology

Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus

(2022) Jamin Liu et al.   mBio

Real-time tracking of bioluminescent influenza A virus infection in mice

(2022) Jin H. Kim et al.   Scientific Reports

Real-Time Visualization of the Infection and Replication of a Mouse-Lethal Recombinant H9N2 Avian Influenza Virus

(2022) Guangjie Lao et al.   Frontiers in Veterinary Science

In Vivo Profiling of Individual Multiciliated Cells during Acute Influenza A Virus Infection

(2022) Cait E. Hamele et al.   JOURNAL OF VIROLOGY

Apolipoprotein E mediates cell resistance to influenza virus infection

(2022) Ping Gao et al.   Science Advances

Visualizing lymphocytic choriomeningitis virus infection in cells and living mice

(2022) Yuxi Wen et al.   iScience

Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge

(2021) Michal Krolik et al.   VACCINE

The evolution and future of influenza pandemic preparedness

(2021) Walter N. Harrington et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

(2021) Adrian Creanga et al.   Nature Communications

M Segment-Based Minigenome System of Severe Fever with Thrombocytopenia Syndrome Virus as a Tool for Antiviral Drug Screening

(2021) Hiroshi Yamada et al.   Viruses-Basel

Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase

(2021) Yu-Jin Kim et al.   JOURNAL OF VIROLOGY

Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity

(2021) Heather M. Froggatt et al.   PLoS Pathogens

Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

(2020) Pierre Bost et al.   CELL

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

(2020) Jun Siong Low et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell type- and replication stage-specific influenza virus responses in vivo

(2020) Elizabeth J. Fay et al.   PLoS Pathogens

Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses

(2020) Rebekah E. Dumm et al.   Cell Reports

Application of a Biologically Contained Reporter System To Study Gain-of-Function H5N1 Influenza A Viruses with Pandemic Potential

(2020) Eva E. Spieler et al.   mSphere

Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function

(2019) Rebekah E. Dumm et al.   Nature Communications

Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries

(2019) Mohamed Abdel-Hakeem   Viruses-Basel

Identification and evaluation of antivirals for Rift Valley fever virus

(2019) Yuekun Lang et al.   VETERINARY MICROBIOLOGY

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity

(2019) Rejane Rua et al.   NATURE IMMUNOLOGY

Classify viruses — the gain is worth the pain

(2019) Jens H. Kuhn et al.   NATURE

A novel fluorescent and bioluminescent Bi-Reporter influenza A virus (BIRFLU) to evaluate viral infections

(2019) Aitor Nogales et al.   JOURNAL OF VIROLOGY

Rift Valley fever virus minigenome system for investigating the role of L protein residues in viral transcription and replication

(2019) Hanna Jérôme et al.   JOURNAL OF GENERAL VIROLOGY

Generation of a Reassortant Influenza A Subtype H3N2 Virus Expressing Gaussia Luciferase

(2019) Lin Wang et al.   Viruses-Basel

Future epidemiological and economic impacts of universal influenza vaccines

(2019) Pratha Sah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance

(2019) Jessica K. Fiege et al.   PLoS Pathogens

Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20

(2018) Junjie Feng et al.   JOURNAL OF VIROLOGY

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection

(2018) Martin Trapecar et al.   Mucosal Immunology

A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody

(2018) Aitor Nogales et al.   Scientific Reports

Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses

(2018) Masaharu Iwasaki et al.   PLoS Pathogens

Mining a Kröhnke Pyridine Library for Anti-Arenavirus Activity

(2018) Pedro O. Miranda et al.   ACS Infectious Diseases

Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo

(2018) Louisa E. Sjaastad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origins and Evolution of the Global RNA Virome

(2018) Yuri I. Wolf et al.   mBio

A novel highly sensitive, rapid and safe Rift Valley fever virus neutralization test

(2017) Paul J. Wichgers Schreur et al.   JOURNAL OF VIROLOGICAL METHODS

In Vivo Imaging of Influenza Virus Infection in Immunized Mice

(2017) Rita Czakó et al.   mBio

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy

(2017) Sandra M. Kallert et al.   Nature Communications

A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor

(2017) Brook E. Heaton et al.   Cell Reports

Rift Valley Fever: An Emerging Mosquito-Borne Disease

(2016) Kenneth J. Linthicum et al.   Annual Review of Entomology

Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity

(2016) Jennifer R. Hamilton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication-competent fluorescent-expressing influenza B virus

(2016) Aitor Nogales et al.   VIRUS RESEARCH

Replication-Competent Influenza A and B Viruses Expressing a Fluorescent Dynamic Timer Protein for In Vitro and In Vivo Studies

(2016) Michael Breen et al.   PLoS One

Identification and Mechanism of Action of a Novel Small-Molecule Inhibitor of Arenavirus Multiplication

(2015) Nhi Ngo et al.   JOURNAL OF VIROLOGY

A Novel Live Pichinde Virus-Based Vaccine Vector Induces Enhanced Humoral and Cellular Immunity after a Booster Dose

(2015) Rekha Dhanwani et al.   JOURNAL OF VIROLOGY

Analysis of Assembly and Budding of Lujo Virus

(2015) Shuzo Urata et al.   JOURNAL OF VIROLOGY

Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines

(2015) Benson Yee Hin Cheng et al.   JOURNAL OF VIROLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Optimisations and Challenges Involved in the Creation of Various Bioluminescent and Fluorescent Influenza A Virus Strains for In Vitro and In Vivo Applications

(2015) Monique I. Spronken et al.   PLoS One

Rift Valley fever virus NSS gene expression correlates with a defect in nuclear mRNA export

(2015) Anna Maria Copeland et al.   VIROLOGY

Efficient generation of influenza virus with a mouse RNA polymerase I-driven all-in-one plasmid

(2015) Xiangmin Zhang et al.   Virology Journal

Multi-Modal Imaging with a Toolbox of Influenza AReporter Viruses

(2015) Vy Tran et al.   Viruses-Basel

Visualizing real-time influenza virus infection, transmission and protection in ferrets

(2015) Erik A. Karlsson et al.   Nature Communications

Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies

(2015) Satoshi Fukuyama et al.   Nature Communications

Generation of a variety of stable Influenza A reporter viruses by genetic engineering of the NS gene segment

(2015) Peter Reuther et al.   Scientific Reports

A GFP Expressing Influenza A Virus to Report In Vivo Tropism and Protection by a Matrix Protein 2 Ectodomain-Specific Monoclonal Antibody

(2015) Sarah De Baets et al.   PLoS One

Long-term survival of influenza virus infected club cells drives immunopathology

(2014) Nicholas S. Heaton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Importin-α7 Is Required for Enhanced Influenza A Virus Replication in the Alveolar Epithelium and Severe Lung Damage in Mice

(2014) Patricia Resa-Infante et al.   JOURNAL OF VIROLOGY

All-in-One Bacmids: an Efficient Reverse Genetics Strategy for Influenza A Virus Vaccines

(2014) H. Chen et al.   JOURNAL OF VIROLOGY

Influenza A Virus Encoding Secreted Gaussia Luciferase as Useful Tool to Analyze Viral Replication and Its Inhibition by Antiviral Compounds and Cellular Proteins

(2014) Nadine Eckert et al.   PLoS One

Genome rearrangement of influenza virus for anti-viral drug screening

(2014) Troy C. Sutton et al.   VIRUS RESEARCH

The Consequences of Reconfiguring the Ambisense S Genome Segment of Rift Valley Fever Virus on Viral Replication in Mammalian and Mosquito Cells and for Genome Packaging

(2014) Benjamin Brennan et al.   PLoS Pathogens

Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid

(2013) Ángela Vázquez-Calvo et al.   ANTIVIRAL RESEARCH

Arenavirus reverse genetics for vaccine development

(2013) E. Ortiz-Riano et al.   JOURNAL OF GENERAL VIROLOGY

In Vivo Bioluminescent Imaging of Influenza A Virus Infection and Characterization of Novel Cross-Protective Monoclonal Antibodies

(2013) N. S. Heaton et al.   JOURNAL OF VIROLOGY

Sodium Hydrogen Exchangers Contribute to Arenavirus Cell Entry

(2013) M. Iwasaki et al.   JOURNAL OF VIROLOGY

Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis Inhibitor

(2013) E. Ortiz-Riano et al.   JOURNAL OF VIROLOGY

Nuclear Relocalization of Polyadenylate Binding Protein during Rift Valley Fever Virus Infection Involves Expression of the NSs Gene

(2013) A. M. Copeland et al.   JOURNAL OF VIROLOGY

Highly Sensitive Real-Time In Vivo Imaging of an Influenza Reporter Virus Reveals Dynamics of Replication and Spread

(2013) V. Tran et al.   JOURNAL OF VIROLOGY

Visualizing influenza virus infection in living mice

(2013) Weiqi Pan et al.   Nature Communications

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection

(2012) Julie Helft et al.   JOURNAL OF CLINICAL INVESTIGATION

GFP-expressing influenza a virus for evaluation of the efficacy of antiviral agents

(2012) Jin Il Kim et al.   JOURNAL OF MICROBIOLOGY

Rift Valley Fever Virus Strain MP-12 Enters Mammalian Host Cells via Caveola-Mediated Endocytosis

(2012) B. Harmon et al.   JOURNAL OF VIROLOGY

Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8+ T Cells

(2012) Matthew M. Hufford et al.   PLoS One

Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune responses

(2012) Ryan A. Langlois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

D471G Mutation in LCMV-NP Affects Its Ability to Self-associate and Results in a Dominant Negative Effect in Viral RNA Synthesis

(2012) Emilio Ortiz-Riaño et al.   Viruses-Basel

Role of Lymphocytic Choriomeningitis Virus (LCMV) in Understanding Viral Immunology: Past, Present and Future

(2012) Xin Zhou et al.   Viruses-Basel

Replication-incompetent influenza A viruses that stably express a foreign gene

(2011) M. Ozawa et al.   JOURNAL OF GENERAL VIROLOGY

Creation of a Nonspreading Rift Valley Fever Virus

(2011) J. Kortekaas et al.   JOURNAL OF VIROLOGY

Expanded Potential for Recombinant Trisegmented Lymphocytic Choriomeningitis Viruses: Protein Production, Antibody Production, and In Vivo Assessment of Biological Function of Genes of Interest

(2011) D. L. Popkin et al.   JOURNAL OF VIROLOGY

Rift Valley Fever Virus Vaccine Lacking the NSs and NSm Genes Is Safe, Nonteratogenic, and Confers Protection from Viremia, Pyrexia, and Abortion following Challenge in Adult and Pregnant Sheep

(2011) B. H. Bird et al.   JOURNAL OF VIROLOGY

The C-Terminal Region of Lymphocytic Choriomeningitis Virus Nucleoprotein Contains Distinct and Segregable Functional Domains Involved in NP-Z Interaction and Counteraction of the Type I Interferon Response

(2011) E. Ortiz-Riano et al.   JOURNAL OF VIROLOGY

Tissue Tropism and Target Cells of NSs-Deleted Rift Valley Fever Virus in Live Immunodeficient Mice

(2011) Céline Gommet et al.   PLoS Neglected Tropical Diseases

Seasonal and Pandemic Human Influenza Viruses Attach Better to Human Upper Respiratory Tract Epithelium than Avian Influenza Viruses

(2010) Debby van Riel et al.   AMERICAN JOURNAL OF PATHOLOGY

A Nine-Segment Influenza A Virus Carrying Subtype H1 and H3 Hemagglutinins

(2010) Q. Gao et al.   JOURNAL OF VIROLOGY

Generation of Replication-Competent Recombinant Influenza A Viruses Carrying a Reporter Gene Harbored in the Neuraminidase Segment

(2010) F. Li et al.   JOURNAL OF VIROLOGY

Use of Single-Cycle Infectious Lymphocytic Choriomeningitis Virus To Study Hemorrhagic Fever Arenaviruses

(2010) W. W. S. I. Rodrigo et al.   JOURNAL OF VIROLOGY

Rescue from Cloned cDNAs and In Vivo Characterization of Recombinant Pathogenic Romero and Live-Attenuated Candid #1 Strains of Junin Virus, the Causative Agent of Argentine Hemorrhagic Fever Disease

(2010) S. F. Emonet et al.   JOURNAL OF VIROLOGY

Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity

(2010) Lukas Flatz et al.   NATURE MEDICINE

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

(2010) B. Manicassamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Species-independent bioassay for sensitive quantification of antiviral type I interferons

(2010) Thomas Kuri et al.   Virology Journal

A Novel System for Identification of Inhibitors of Rift Valley Fever Virus Replication

(2010) Mary E. Piper et al.   Viruses-Basel

Reverse genetics technology for Rift Valley fever virus: Current and future applications for the development of therapeutics and vaccines

(2009) Michele Bouloy et al.   ANTIVIRAL RESEARCH

Development of Infectious Clones for Virulent and Avirulent Pichinde Viruses: a Model Virus To Study Arenavirus-Induced Hemorrhagic Fevers

(2009) S. Lan et al.   JOURNAL OF VIROLOGY

A One-Plasmid System To Generate Influenza Virus in Cultured Chicken Cells for Potential Use in Influenza Vaccine

(2009) X. Zhang et al.   JOURNAL OF VIROLOGY

Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies

(2009) L. Martinez-Sobrido et al.   JOURNAL OF VIROLOGY

Efficient Reverse Genetics Generation of Infectious Junin Viruses Differing in Glycoprotein Processing

(2009) C. G. Albarino et al.   JOURNAL OF VIROLOGY

Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus

(2009) L. Martinez-Sobrido et al.   JOURNAL OF VIROLOGY

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest

(2009) S. F. Emonet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T7 RNA polymerase-dependent and -independent systems for cDNA-based rescue of Rift Valley fever virus

(2008) M. Habjan et al.   JOURNAL OF GENERAL VIROLOGY

Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World Arenaviruses

(2008) J. M. Rojek et al.   JOURNAL OF VIROLOGY

Rift Valley Fever Virus Lacking the NSs and NSm Genes Is Highly Attenuated, Confers Protective Immunity from Virulent Virus Challenge, and Allows for Differential Identification of Infected and Vaccinated Animals

(2008) B. H. Bird et al.   JOURNAL OF VIROLOGY

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE

RNA polymerase I-mediated expression of viral RNA for the rescue of infectious virulent and avirulent Rift Valley fever viruses

(2008) Agnès Billecocq et al.   VIROLOGY

Establishment and characterization of plasmid-driven minigenome rescue systems for Nipah virus: RNA polymerase I- and T7-catalyzed generation of functional paramyxoviral RNA

(2007) Alexander Freiberg et al.   VIROLOGY