期刊
VIROLOGY
卷 486, 期 -, 页码 88-93出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.09.003
关键词
mRNA; Rift Valley fever virus; NSS; RNA export; PABP1
类别
资金
- Joint Sciences and Technology Office of the US Defense Threat Reduction Agency
We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSs gene, but not the N, G(N) or NSM genes correlated with mRNA nuclear accumulation. Nuclear accumulation of host mRNA was not observed in cells infected with a strain of RVFV lacking the gene encoding NSs, confirming that expression of NSs is likely responsible for this phenomenon. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据