Combined Structure- and Ligand-Based Approach for the Identification of Inhibitors of AcrAB-TolC in Escherichia coli
出版年份 2023 全文链接
标题
Combined Structure- and Ligand-Based Approach for the Identification of Inhibitors of AcrAB-TolC in Escherichia coli
作者
关键词
-
出版物
ACS Infectious Diseases
Volume -, Issue -, Pages -
出版商
American Chemical Society (ACS)
发表日期
2023-10-27
DOI
10.1021/acsinfecdis.3c00350
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- In vitro synergistic activity of NCL195 in combination with colistin against Gram-negative bacterial pathogens
- (2021) Hang Thi Nguyen et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- In Silico Strategies in Tuberculosis Drug Discovery
- (2020) Stephani Joy Y. Macalino et al. MOLECULES
- Antibiotics in the clinical pipeline in October 2019
- (2020) Mark S. Butler et al. JOURNAL OF ANTIBIOTICS
- Structure- and Ligand-Based Virtual Screening on DUD-E+: Performance Dependence on Approximations to the Binding Pocket
- (2020) Ann E. Cleves et al. Journal of Chemical Information and Modeling
- Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
- (2020) Elizabeth M. Grimsey et al. mBio
- Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment
- (2020) Dijun Du et al. STRUCTURE
- Design and synthesis of novel 4-substituted quinazoline-2-carboxamide derivatives targeting AcrB to reverse the bacterial multidrug resistance
- (2020) Xinjie Gu et al. BIOORGANIC CHEMISTRY
- Merging Ligand-Based and Structure-Based Methods in Drug Discovery: An Overview of Combined Virtual Screening Approaches
- (2020) Javier Vázquez et al. MOLECULES
- Reversing Resistance to Counter Antimicrobial Resistance in the World Health Organisation's Critical Priority of Most Dangerous Pathogens
- (2019) Henrietta Venter BIOSCIENCE REPORTS
- Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance
- (2019) Chaobin Jin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Molecular basis for the different interactions of congeneric substrates with the polyspecific transporter AcrB
- (2019) Ivana Malvacio et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The 2019 Garrod Lecture: MDR efflux in Gram-negative bacteria—how understanding resistance led to a new tool for drug discovery
- (2019) Laura J V Piddock JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- AcrB: a mean, keen, drug efflux machine
- (2019) Jessica Kobylka et al. Annals of the New York Academy of Sciences
- Structural optimization of natural product nordihydroguaretic acid to discover novel analogues as AcrB inhibitors
- (2019) Yinhu Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance
- (2018) Rumana Mowla et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Inventing new therapies without reinventing the wheel: the power of drug repurposing
- (2018) Andreas Papapetropoulos et al. BRITISH JOURNAL OF PHARMACOLOGY
- Design, synthesis and biological activity evaluation of novel 4-subtituted 2-naphthamide derivatives as AcrB inhibitors
- (2018) Yinhu Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Multidrug efflux pumps: structure, function and regulation
- (2018) Dijun Du et al. NATURE REVIEWS MICROBIOLOGY
- Structure and mechanism of bacterial tripartite efflux pumps
- (2018) Arthur Neuberger et al. RESEARCH IN MICROBIOLOGY
- l -Methionine anti-biofilm activity against Pseudomonas aeruginosa is enhanced by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor
- (2018) Do-Yeon Cho et al. International Forum of Allergy & Rhinology
- A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load
- (2018) Abigail L. Reens et al. PLoS Pathogens
- The Fight Against Antimicrobial Resistance Is Confounded by a Global Increase in Antibiotic Usage
- (2018) Mark A. T. Blaskovich ACS Infectious Diseases
- Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa
- (2018) Do-Yeon Cho et al. American Journal of Rhinology & Allergy
- PubChem 2019 update: improved access to chemical data
- (2018) Sunghwan Kim et al. NUCLEIC ACIDS RESEARCH
- Pseudomonas aeruginosa in cystic fibrosis patients with c.1652G›A (G551D)-CFTR treated with ivacaftor-Changes in microbiological parameters
- (2017) B. C. Millar et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors
- (2017) Andrea Astolfi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Switch Loop Flexibility Affects Substrate Transport of the AcrB Efflux Pump
- (2017) Reinke T. Müller et al. JOURNAL OF MOLECULAR BIOLOGY
- New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria
- (2017) Gabriella Spengler et al. MOLECULES
- An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
- (2017) Zhao Wang et al. eLife
- Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa
- (2017) Pengfei She et al. MicrobiologyOpen
- Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis
- (2017) Jonathan Nzakizwanayo et al. Scientific Reports
- Multidrug efflux pumps and their role in antibiotic and antiseptic resistance: a pharmacodynamic perspective
- (2016) Sandrine Alibert et al. Expert Opinion on Drug Metabolism & Toxicology
- Efflux as a mechanism of antimicrobial drug resistance in clinical relevant microorganisms: the role of efflux inhibitors
- (2016) Clarissa Willers et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The Influence of Efflux Pump Inhibitors on the Activity of Non-Antibiotic NSAIDS against Gram-Negative Rods
- (2016) Agnieszka E. Laudy et al. PLoS One
- Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
- (2016) Hanno Sjuts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tripartite assembly of RND multidrug efflux pumps
- (2016) Laetitia Daury et al. Nature Communications
- Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens
- (2016) Sirijan Santajit et al. Biomed Research International
- Role of computer-aided drug design in modern drug discovery
- (2015) Stephani Joy Y. Macalino et al. ARCHIVES OF PHARMACAL RESEARCH
- Structure, mechanism and cooperation of bacterial multidrug transporters
- (2015) Dijun Du et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- ZINC 15 – Ligand Discovery for Everyone
- (2015) Teague Sterling et al. Journal of Chemical Information and Modeling
- POSIT: Flexible Shape-Guided Docking For Pose Prediction
- (2015) Brian P. Kelley et al. Journal of Chemical Information and Modeling
- RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition
- (2015) Henrietta Venter et al. Frontiers in Microbiology
- Switch-Loop Flexibility Affects Transport of Large Drugs by the Promiscuous AcrB Multidrug Efflux Transporter
- (2014) Hi-jea Cha et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors
- (2014) Attilio V. Vargiu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance
- (2014) Jessica MA Blair et al. Future Microbiology
- Antibacterial properties of the CFTR potentiator ivacaftor
- (2014) Leah R. Reznikov et al. Journal of Cystic Fibrosis
- Structure of the AcrAB–TolC multidrug efflux pump
- (2014) Dijun Du et al. NATURE
- Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening and In Vitro Validation
- (2014) Vasudevan Aparna et al. PLoS One
- Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump
- (2014) Thelma Ohene-Agyei et al. MicrobiologyOpen
- RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii: Major Role for AdeABC Overexpression and AdeRS Mutations
- (2013) Eun-Jeong Yoon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli
- (2013) Timothy J. Opperman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- How far can virtual screening take us in drug discovery?
- (2013) Supratik Kar et al. Expert Opinion on Drug Discovery
- Structural basis for the inhibition of bacterial multidrug exporters
- (2013) Ryosuke Nakashima et al. NATURE
- Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin
- (2012) Jadwiga Handzlik et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance
- (2012) E. C. Hobbs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
- (2012) T. Eicher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin and thioridazine
- (2011) E. Abbate et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- FRED Pose Prediction and Virtual Screening Accuracy
- (2011) Mark McGann Journal of Chemical Information and Modeling
- Optimized Nile Red Efflux Assay of AcrAB-TolC Multidrug Efflux System Shows Competition between Substrates
- (2010) J. A. Bohnert et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Promiscuous partnering and independent activity of MexB, the multidrug transporter protein fromPseudomonas aeruginosa
- (2010) Alexander Welch et al. BIOCHEMICAL JOURNAL
- Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database
- (2010) Paul C. D. Hawkins et al. Journal of Chemical Information and Modeling
- New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
- (2010) Jonathan B. Baell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli
- (2010) Y. Takatsuka et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small RNAs and Small Proteins Involved in Resistance to Cell Envelope Stress and Acid Shock in Escherichia coli: Analysis of a Bar-Coded Mutant Collection
- (2009) E. C. Hobbs et al. JOURNAL OF BACTERIOLOGY
- RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine
- (2008) A. M. Bailey et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB
- (2008) J. A. Bohnert et al. JOURNAL OF BACTERIOLOGY
- Prediction of Metabolism by Cytochrome P450 2C9: Alignment and Docking Studies of a Validated Database of Substrates
- (2008) Matthew J. Sykes et al. JOURNAL OF MEDICINAL CHEMISTRY
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