Low level of tonic interferon signaling is associated with enhanced susceptibility to SARS-CoV-2 variants of concern in human lung organoids

Innate immune evasion strategies of SARS-CoV-2

(2023) Judith M. Minkoff et al.   NATURE REVIEWS MICROBIOLOGY

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

(2023) Erola Pairo-Castineira et al.   NATURE

Influence of ICU Surge and Capacity on COVID Mortality Across U.S. States and Regions During the COVID-19 Pandemic

(2023) Patric W. Gibbons et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study

(2022) Nicole Wolter et al.   LANCET

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

(2022) Huiping Shuai et al.   NATURE

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

(2022) Peter J. Halfmann et al.   NATURE

Trends in Disease Severity and Health Care Utilization During the Early Omicron Variant Period Compared with Previous SARS-CoV-2 High Transmission Periods — United States, December 2020–January 2022

(2022) A. Danielle Iuliano et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

(2022) Emily Speranza et al.   Life Science Alliance

SARS-CoV-2 Omicron variants BA.1 and BA.2 both show similarly reduced disease severity of COVID-19 compared to Delta, Germany, 2021 to 2022

(2022) Claudia Sievers et al.   Eurosurveillance

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

(2022) Preetish Kadur Lakshminarasimha Murthy et al.   NATURE

An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

(2022) Lindsay Broadbent et al.   PLoS One

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study

(2022) Adam S Lauring et al.   BMJ-British Medical Journal

Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters

(2022) Shuofeng Yuan et al.   SCIENCE

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

(2022) Federico Armando et al.   Nature Communications

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters

(2022) Melanie Rissmann et al.   Emerging Microbes & Infections

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells

(2022) Dixit Tandel et al.   Microbiology Spectrum

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

(2022) Neeltje van Doremalen et al.   Science Advances

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

(2022) Taewoo Kim et al.   iScience

Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys

(2021) Emily Speranza et al.   Science Translational Medicine

Predicting mammalian species at risk of being infected by SARS-CoV-2 from an ACE2 perspective

(2021) Yulong Wei et al.   Scientific Reports

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

(2021) Sirui Zhou et al.   NATURE MEDICINE

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

(2021) Suzannah J. Rihn et al.   PLOS BIOLOGY

Inactivation of SARS-CoV-2 Laboratory Specimens

(2021) Elaine Haddock et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

(2021) Apoorva Mulay et al.   Cell Reports

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness

(2021) Aziz Sheikh et al.   LANCET

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study

(2021) Katherine A Twohig et al.   LANCET INFECTIOUS DISEASES

In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin

(2021) Sakshi Piplani et al.   Scientific Reports

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

(2021) Courtney Tindle et al.   eLife

Difference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study

(2021) Waasila Jassat et al.   Lancet Global Health

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

(2021) Akatsuki Saito et al.   NATURE

Evolution of enhanced innate immune evasion by SARS-CoV-2

(2021) Lucy G. Thorne et al.   NATURE

A prenylated dsRNA sensor protects against severe COVID-19

(2021) Arthur Wickenhagen et al.   SCIENCE

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

(2021) Vincent J. Munster et al.   Science Advances

Decreased severity of disease during the first global omicron variant covid-19 outbreak in a large hospital in tshwane, south africa

(2021) F. Abdullah et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19

(2020) Huilan Zhang et al.   ANNALS OF INTERNAL MEDICINE

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

(2020) Vincent J. Munster et al.   NATURE

Clinical and pathological investigation of patients with severe COVID-19

(2020) Shaohua Li et al.   JCI Insight

Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction

(2020) Hiroaki Katsura et al.   Cell Stem Cell

Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2

(2020) Jeonghwan Youk et al.   Cell Stem Cell

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

(2020) Mart M Lamers et al.   EMBO JOURNAL

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

(2020) Ameen A. Salahudeen et al.   NATURE

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

(2019) Konrad C. Bradley et al.   Cell Reports

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

(2016) Victoria A. Meliopoulos et al.   PLoS Pathogens

Contrasted patterns of variation and evolutionary convergence at the antiviral OAS1 gene in old world primates

(2015) Ian Fish et al.   IMMUNOGENETICS

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals

(2013) Ana Lemos de Matos et al.   PLoS One

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY