GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Comorbidities, multimorbidity and COVID-19

(2023) Clark D. Russell et al.   NATURE MEDICINE

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

(2022) Bo Meng et al.   NATURE

Whole genome sequencing reveals host factors underlying critical Covid-19

(2022) Athanasios Kousathanas et al.   NATURE

Endotoxin-induced acute lung injury in mice with postnatal deletion of nephronectin

(2022) Carole L. Wilson et al.   PLoS One

A common TMPRSS2 variant has a protective effect against severe COVID-19

(2022) Alessia David et al.   Current Research in Translational Medicine

Novel genes and sex differences in COVID-19 severity

(2022) Raquel Cruz et al.   HUMAN MOLECULAR GENETICS

Detailed stratified GWAS analysis for severe COVID-19 in four European populations

(2022) Frauke Degenhardt et al.   HUMAN MOLECULAR GENETICS

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis

(2022) Obbina Abani et al.   LANCET

A first update on mapping the human genetic architecture of COVID-19

(2022) et al.   NATURE

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Mapping the human genetic architecture of COVID-19

(2021)   NATURE

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

Choosing drugs for UK COVID-19 treatment trials

(2021) Patrick F. Chinnery et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

(2020) Bo Li et al.   Nature Communications

Advances in the development of phosphodiesterase-4 inhibitors

(2020) Ting Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A simple new approach to variable selection in regression, with application to genetic fine mapping

(2020) Gao Wang et al.   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19

(2020) Nicholas Parkinson et al.   Scientific Reports

Integrating predicted transcriptome from multiple tissues improves association detection

(2019) Alvaro N. Barbeira et al.   PLoS Genetics

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

(2018) Alvaro N. Barbeira et al.   Nature Communications

Causal associations between risk factors and common diseases inferred from GWAS summary data

(2018) Zhihong Zhu et al.   Nature Communications

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

CD8 + T Cells Orchestrate pDC-XCR1 + Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

(2017) Anna Brewitz et al.   IMMUNITY

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

A promoter-level mammalian expression atlas

(2014)   NATURE

Lead identification of novel and selective TYK2 inhibitors

(2013) Jun Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Two Rare Disease-Associated Tyk2 Variants Are Catalytically Impaired but Signaling Competent

(2013) Z. Li et al.   JOURNAL OF IMMUNOLOGY

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols