Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

Decoding the genetic relationship between Alzheimer’s disease and type 2 diabetes: potential risk variants and future direction for North Africa

(2023) Wided Boukhalfa et al.   Frontiers in Aging Neuroscience

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study

(2023) Amena Keshawarz et al.   Scientific Reports

Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

(2022) Eliza Fraszczyk et al.   DIABETOLOGIA

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

(2022) Anubha Mahajan et al.   NATURE GENETICS

New insights into the genetic etiology of Alzheimer’s disease and related dementias

(2022) Céline Bellenguez et al.   NATURE GENETICS

Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI

(2022) Yunju Yang et al.   BRAIN

An epigenome-wide association study of insulin resistance in African Americans

(2022) Felix P. Chilunga et al.   Clinical Epigenetics

Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

(2022) Elizabeth M. Rhea et al.   Biomedicines

Blood transcriptomic biomarkers of alcohol consumption and cardiovascular disease risk factors: the Framingham Heart Study

(2022) Jiantao Ma et al.   HUMAN MOLECULAR GENETICS

Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease

(2022) Tiago C. Silva et al.   Nature Communications

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease

(2022) Jiantao Ma et al.   Scientific Reports

Identification of Cathepsin D as a Plasma Biomarker for Alzheimer’s Disease

(2021) Jae-Whan Kim et al.   Cells

Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

(2021) Josina Bunk et al.   Frontiers in Cell and Developmental Biology

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

(2021) Josine L. Min et al.   NATURE GENETICS

The trans-ancestral genomic architecture of glycemic traits

(2021) Ji Chen et al.   NATURE GENETICS

A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

(2021) Rebecca G. Smith et al.   Nature Communications

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

(2021) Min-A Jhun et al.   Nature Communications

Regulation of PPARα by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity

(2021) Francisco Sáez-Orellana et al.   JCI Insight

The impact of diabetes on cognitive impairment and its progression to dementia

(2021) Abigail Dove et al.   Alzheimers & Dementia

Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

(2021) Emrin Horgusluoglu et al.   Alzheimers & Dementia

CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes

(2020) Maopei Chen et al.   Science Advances

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

(2020) Caitlin N. Suire et al.   Alzheimers Research & Therapy

The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus

(2020) Sanabil Ali Hassan Ahmed et al.   Clinical Epigenetics

Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions

(2020) Qingqin S. Li et al.   Clinical Epigenetics

Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals

(2020) Lingling Ding et al.   Frontiers in Endocrinology

Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson’s Disease

(2020) Juhee Kang et al.   CTS-Clinical and Translational Science

Activation of Wnt/β‐catenin signaling restores insulin sensitivity in insulin resistant neurons through transcriptional regulation of IRS‐1

(2020) Shijiao Tian et al.   JOURNAL OF NEUROCHEMISTRY

Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells

(2020) Devika P. Bagchi et al.   Molecular Metabolism

Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals

(2019) Patricia R. Braun et al.   Translational Psychiatry

Shared genetic architecture between metabolic traits and Alzheimer’s disease: a large-scale genome-wide cross-trait analysis

(2019) Zhaozhong Zhu et al.   HUMAN GENETICS

A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Non-Alcoholic Fatty Liver Disease

(2019) Jiantao Ma et al.   DIABETES

Genetic association testing using the GENESIS R/Bioconductor package

(2019) Stephanie M Gogarten et al.   BIOINFORMATICS

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

(2019) Jun Liu et al.   Nature Communications

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

(2019) Alexia Cardona et al.   DIABETES

Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans

(2019) Lingling Ding et al.   DIABETOLOGIA

Genetic architecture of subcortical brain structures in 38,851 individuals

(2019) Claudia L. Satizabal et al.   NATURE GENETICS

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

(2019) Lin Jia et al.   Molecular Brain

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

(2018) Andrew T. McKenzie et al.   Scientific Reports

Epigenetics and Epigenomics: Implications for Diabetes and Obesity

(2018) Evan D. Rosen et al.   DIABETES

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

(2018) Philip L. De Jager et al.   Scientific Data

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

(2017) S. Alford et al.   Obesity Reviews

Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

(2017) Michael M. Mendelson et al.   PLOS MEDICINE

Dnmt3a is an epigenetic mediator of adipose insulin resistance

(2017) Dongjoo You et al.   eLife

BECon: a tool for interpreting DNA methylation findings from blood in the context of brain

(2017) R D Edgar et al.   Translational Psychiatry

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations

(2016) Brian H. Chen et al.   DIABETES

Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults

(2016) Siobhan M. Hoscheidt et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigenetics of dementia: understanding the disease as a transformation rather than a state

(2016) Bryan Maloney et al.   LANCET NEUROLOGY

Disease variants alter transcription factor levels and methylation of their binding sites

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study

(2016) Jennifer Kriebel et al.   PLoS One

Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study

(2016) Mithun Das et al.   PLoS One

Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

(2015) Martina Bocchetta et al.   Alzheimers & Dementia

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

(2015) Marina Boccardi et al.   Alzheimers & Dementia

DNMT3A rs1550117 Polymorphism is Associated With Late-Onset Alzheimer’s Disease in a Chinese Population

(2015) Chen Ling et al.   American Journal of Alzheimers Disease and Other Dementias

missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform

(2015) Belinda Phipson et al.   BIOINFORMATICS

Protein biomarkers for insulin resistance and type 2 diabetes risk in two large community cohorts

(2015) Christoph Nowak et al.   DIABETES

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes

(2015) Eilis Hannon et al.   Epigenetics

Novel epigenetic determinants of type 2 diabetes in Mexican-American families

(2015) Hemant Kulkarni et al.   HUMAN MOLECULAR GENETICS

The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions

(2015) Ashraf Virmani et al.   MOLECULAR NEUROBIOLOGY

Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference

(2015) Stella Aslibekyan et al.   Obesity

DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

(2015) Leonidas Chouliaras et al.   Epigenomics

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epigenome-Wide Association Study of Fasting Blood Lipids in the Genetics of Lipid-Lowering Drugs and Diet Network Study

(2014) Marguerite R. Irvin et al.   CIRCULATION

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Wnt signaling in the nervous system and in Alzheimer's disease

(2014) N. C. Inestrosa et al.   Journal of Molecular Cell Biology

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments

(2013) J. Wang et al.   DIABETES

Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study

(2013) B. Hidalgo et al.   DIABETES

Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol

(2013) Marina Boccardi et al.   JOURNAL OF NEUROIMAGING

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis

(2009) M. Schuur et al.   NEUROBIOLOGY OF AGING

Cathepsin D expression is decreased in Alzheimer's disease fibroblasts

(2006) Lorena Urbanelli et al.   NEUROBIOLOGY OF AGING