Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior

A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

(2022) Lior Matityahu et al.   eLife

Striatal cholinergic transmission. focus on nicotinic receptors’ influence in striatal circuits

(2021) Maxime Assous   EUROPEAN JOURNAL OF NEUROSCIENCE

Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice

(2021) Kathia I. Ramírez-Armenta et al.   NEUROPSYCHOPHARMACOLOGY

Interfacing behavioral and neural circuit models for habit formation

(2020) Talia N. Lerner   JOURNAL OF NEUROSCIENCE RESEARCH

Instrumental learning in a mouse model for obsessive-compulsive disorder: Impaired habit formation in Sapap3 mutants

(2020) I. Ehmer et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies

(2020) Daniel Dautan et al.   Nature Communications

Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity

(2020) Jian Xu et al.   AMERICAN JOURNAL OF PSYCHIATRY

Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice

(2020) Lotfi C. Hadjas et al.   NEUROPSYCHOPHARMACOLOGY

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

(2020) Miao Jing et al.   NATURE METHODS

Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

(2020) Eric M. Prager et al.   NEURON

Strengthened inputs from secondary motor cortex to striatum in a mouse model of compulsive behavior

(2019) Victoria L. Corbit et al.   JOURNAL OF NEUROSCIENCE

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

(2019) Luis Carrillo-Reid et al.   eLife

Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder

(2019) Lotfi C. Hadjas et al.   Scientific Reports

Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum

(2018) Luciana R. Frick et al.   BRAIN BEHAVIOR AND IMMUNITY

Cholinergic modulation of striatal microcircuits

(2018) Nilupaer Abudukeyoumu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour

(2018) Jesse Wood et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders

(2018) Joshua L. Plotkin et al.   NEUROSCIENTIST

Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

(2017) Wenting Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors

(2017) Stefania Bellini et al.   JOURNAL OF NEUROSCIENCE

Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis

(2017) Paul D Arnold et al.   MOLECULAR PSYCHIATRY

Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice

(2016) Kristen K. Ade et al.   BIOLOGICAL PSYCHIATRY

Direct and indirect dorsolateral striatum pathways reinforce different action strategies

(2016) Ana M. Vicente et al.   CURRENT BIOLOGY

Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice

(2016) Q. Zhang et al.   JOURNAL OF NEUROSCIENCE

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

Striatal activation reflects urgency in perceptual decision making

(2016) Leendert van Maanen et al.   NEUROIMAGE

Pathway-Specific Striatal Substrates for Habitual Behavior

(2016) Justin K. O’Hare et al.   NEURON

Striatal circuits, habits, and implications for obsessive–compulsive disorder

(2015) Eric Burguière et al.   CURRENT OPINION IN NEUROBIOLOGY

DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS

(2015) Susanne E. Ahmari et al.   DEPRESSION AND ANXIETY

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

(2015) Weixing Shen et al.   NEURON

Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome

(2015) Meiyu Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective

(2014) David L. Pauls et al.   NATURE REVIEWS NEUROSCIENCE

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

(2014) Tim Fieblinger et al.   Nature Communications

Circuit-Selective Striatal Synaptic Dysfunction in the Sapap3 Knockout Mouse Model of Obsessive-Compulsive Disorder

(2013) Yehong Wan et al.   BIOLOGICAL PSYCHIATRY

Striatum-dependent habits are insensitive to both increases and decreases in reinforcer value in mice

(2013) Jennifer J. Quinn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of dendritic calcium release in striatal spiny projection neurons

(2013) Joshua L. Plotkin et al.   JOURNAL OF NEUROPHYSIOLOGY

Concurrent activation of striatal direct and indirect pathways during action initiation

(2013) Guohong Cui et al.   NATURE

Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

(2013) E. Burguiere et al.   SCIENCE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Translational approaches to obsessive-compulsive disorder: from animal models to clinical treatment

(2011) NA Fineberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cholinergic modulation of synaptic integration and dendritic excitability in the striatum

(2011) Ian Antón Oldenburg et al.   CURRENT OPINION IN NEUROBIOLOGY

Neurobiology of obsessive–compulsive disorder: insights into neural circuitry dysfunction through mouse genetics

(2011) Jonathan T Ting et al.   CURRENT OPINION IN NEUROBIOLOGY

A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons

(2011) Michael J. Grybko et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sapap3 Deletion Anomalously Activates Short-Term Endocannabinoid-Mediated Synaptic Plasticity

(2011) M. Chen et al.   JOURNAL OF NEUROSCIENCE

Sapap3 Deletion Causes mGluR5-Dependent Silencing of AMPAR Synapses

(2011) Y. Wan et al.   JOURNAL OF NEUROSCIENCE

Synaptically driven state transitions in distal dendrites of striatal spiny neurons

(2011) Joshua L Plotkin et al.   NATURE NEUROSCIENCE

The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder

(2011) Ke Wu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Key role of striatal cholinergic interneurons in processes leading to arrest of motor stereotypies

(2010) Verena Aliane et al.   BRAIN

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

(2010) Sergey V Shmelkov et al.   NATURE MEDICINE

Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+currents

(2009) Marcello D’Ascenzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action

(2009) Bernard W Balleine et al.   NEUROPSYCHOPHARMACOLOGY

Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites

(2008) M. Day et al.   JOURNAL OF NEUROSCIENCE

Drd1a-tdTomato BAC Transgenic Mice for Simultaneous Visualization of Medium Spiny Neurons in the Direct and Indirect Pathways of the Basal Ganglia

(2008) J. A. Shuen et al.   JOURNAL OF NEUROSCIENCE

Multiple rare SAPAP3 missense variants in trichotillomania and OCD

(2008) S Züchner et al.   MOLECULAR PSYCHIATRY