Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway

A Novel Progress: Glial Cells and Inflammatory Pain

(2022) Hongji Wang et al.   ACS Chemical Neuroscience

Interleukin 33-mediated inhibition of A-type K+ channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice

(2022) Yiru Wang et al.   Theranostics

Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

(2022) Hongwei Fan et al.   Frontiers in Neuroscience

Makatoxin-3, a thermostable Nav1.7 agonist from Buthus martensii Karsch (BmK) scorpion elicits non-narcotic analgesia in inflammatory pain models

(2022) Yonggen Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Screening 5‐lipoxygenase inhibitors from selected traditional Chinese medicines and isolation of the active compounds from Polygoni Cuspidati Rhizoma by an on‐line bioactivity evaluation system

(2022) Hong‐Bo Xu et al.   BIOMEDICAL CHROMATOGRAPHY

Recent advances in the therapeutic potential of emodin for human health

(2022) Javad Sharifi-Rad et al.   BIOMEDICINE & PHARMACOTHERAPY

Effects of resveratrol on lipid metabolism in liver of red tilapia Oreochromis niloticus

(2022) Yao Zheng et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization

(2022) Chujun Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway

(2021) Xiaobo Dong et al.   Drug Design Development and Therapy

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes

(2021) Weimin Fan et al.   Journal of Inflammation Research

Qianghuo Shengshi decoction exerts anti-inflammatory and analgesic via MAPKs/CREB signaling pathway

(2021) Nan Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The analgesic activities of total alkaloids of the ethnic medicine Cynanchum komarovii Al. Iljinski

(2021) Ruizhou Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuraxial Cytokines in Pain States

(2020) Gilson Gonçalves dos Santos et al.   Frontiers in Immunology

Central Neuropathic Mechanisms in Pain Signaling Pathways: Current Evidence and Recommendations

(2020) Omar Viswanath et al.   ADVANCES IN THERAPY

Pain and Inflammation

(2020) James David Adams   CURRENT MEDICINAL CHEMISTRY

Webina: An Open-Source Library and Web App that Runs AutoDock Vina Entirely in the Web Browser

(2020) Yuri Kochnev et al.   BIOINFORMATICS

Polydatin for treating atherosclerotic diseases: A functional and mechanistic overview

(2020) Min Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Systemic inflammatory markers in neck pain: A systematic review with meta‐analysis

(2020) Scott F. Farrell et al.   EUROPEAN JOURNAL OF PAIN

Purinergic signaling as a basis of acupuncture-induced analgesia

(2020) Jin-Rong He et al.   Purinergic Signalling

Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain

(2020) Yajing Ma et al.   Journal of Pain Research

Anti-Inflammatory and Anti-Nociceptive Effects of Cocoa: A Review on Future Perspectives in Treatment of Pain

(2020) Martina De Feo et al.   Pain and Therapy

Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells

(2020) Weihua Ding et al.   ANESTHESIA AND ANALGESIA

The therapeutic importance of acid-base balance

(2020) Bianca N. Quade et al.   BIOCHEMICAL PHARMACOLOGY

3α-Angeloyloxy-ent-kaur-16-en-19-oic Acid Isolated from Wedelia trilobata L. Alleviates Xylene-Induced Mouse Ear Edema and Inhibits NF-κB and MAPK Pathway in LPS-Stimulated Macrophages

(2020) Jingwen Xu et al.   JOURNAL OF NATURAL PRODUCTS

Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation

(2019) Wan-Chun Chang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats

(2019) Yu-Peng Guo et al.   Frontiers in Molecular Neuroscience

Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy

(2019) Fedir Bokhovchuk et al.   FEBS Journal

Analgesic Effect of Zanthoxylum nitidum Extract in Inflammatory Pain Models Through Targeting of ERK and NF-κB Signaling

(2019) Fenfen Qin et al.   Frontiers in Pharmacology

Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain

(2019) Tasuku Nishino et al.   Molecular Brain

Intestinal metabolism of Polygonum cuspidatum in vitro and in vivo

(2018) Jinfeng Fu et al.   BIOMEDICAL CHROMATOGRAPHY

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

(2018) Ryan S. Tonkin et al.   EXPERIMENTAL NEUROLOGY

Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells

(2018) Adriana Di Benedetto et al.   International Journal of Medical Sciences

PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

(2018) Binbin Wang et al.   JOURNAL OF HEADACHE AND PAIN

Characterization of three mitogen-activated protein kinases (MAPK) genes reveals involvement of ERK and JNK, not p38 in defense against bacterial infection in Yesso scallop Patinopecten yessoensis

(2016) Yan Sun et al.   FISH & SHELLFISH IMMUNOLOGY

Emodin-8-O-glucuronic acid, from the traditional Chinese medicine qinghuobaiduyin, affects the secretion of inflammatory cytokines in LPS-stimulated raw 264.7 cells via HSP70

(2016) Ping Wang et al.   Molecular Medicine Reports

Resveratrol, obesity and diabetes

(2010) Katarzyna Szkudelska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY