Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway

Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease�1 in SH‑SY5Y cells: Involvement of the PI3K/AKT pathway

(2020) Lei Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammatory Response

(2020) Wen Zhang et al.   MEDIATORS OF INFLAMMATION

MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression

(2020) Zhihao Chen et al.   EXPERIMENTAL NEUROLOGY

Curcumin alleviates OGD/R‐induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF‐κB to suppress inflammation and apoptosis

(2020) Chao Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission

(2019) Lidong Zhao et al.   Frontiers in Pharmacology

Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia

(2019) Rong-Rong Li et al.   MOLECULES

Pterostilbene Attenuates Astrocytic Inflammation and Neuronal Oxidative Injury After Ischemia-Reperfusion by Inhibiting NF-κB Phosphorylation

(2019) Haixiao Liu et al.   Frontiers in Immunology

Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

(2019) Yingze Ye et al.   Frontiers in Cellular Neuroscience

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation

(2018) Jun-rong Zhu et al.   ACTA PHARMACOLOGICA SINICA

RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways

(2017) Lingli Gong et al.   Cell Death & Disease

Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway

(2017) Honglin Yan et al.   Cell Death & Disease

Pterostilbene protects against acute renal ischemia reperfusion injury and inhibits oxidative stress, inducible nitric oxide synthase expression and inflammation in rats via the Toll‑like receptor 4/nuclear factor‑κB signaling pathway

(2017) Dan Gao et al.   Experimental and Therapeutic Medicine

TREM2 protects against cerebral ischemia/reperfusion injury

(2017) Rong Wu et al.   Molecular Brain

Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons

(2017) Shanshan Sun et al.   Redox Biology

Hexahydrocurcumin protects against cerebral ischemia/reperfusion injury, attenuates inflammation, and improves antioxidant defenses in a rat stroke model

(2017) Piyawadee Wicha et al.   PLoS One

Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma

(2016) Ming-jie Pang et al.   ACTA PHARMACOLOGICA SINICA

Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis

(2016) Yaqiong Zhang et al.   NEUROCHEMICAL RESEARCH

Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2

(2015) Yan-tao Han et al.   ACTA PHARMACOLOGICA SINICA

Imaging Biomarkers in Acute Ischemic Stroke Trials: A Systematic Review

(2015) G.W.J. Harston et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

NOD2 is Involved in the Inflammatory Response after Cerebral Ischemia-Reperfusion Injury and Triggers NADPH Oxidase 2-Derived Reactive Oxygen Species

(2015) Huiqing Liu et al.   International Journal of Biological Sciences

Reducing Effect of IL-32α in the Development of Stroke Through Blocking of NF-κB, but Enhancement of STAT3 Pathways

(2014) Chul Ju Hwang et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

(2014) Theodore Kalogeris et al.   Redox Biology

Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-Induced Rats

(2012) Su-xiang Feng et al.   PHYTOTHERAPY RESEARCH

Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

(2011) Xingfen Su et al.   MEDIATORS OF INFLAMMATION

Preparative Isolation of Three Anthraquinones from Rumex japonicus by High-Speed Counter-Current Chromatography

(2011) Shuying Guo et al.   MOLECULES

Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection

(2010) Joo Eun Jung et al.   MOLECULAR NEUROBIOLOGY

NF-κB signaling in cerebral ischemia

(2008) D.A. Ridder et al.   NEUROSCIENCE