Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

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Caspase-1 promotes monocyte-macrophage differentiation by repressing PPARγ

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Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

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Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes

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Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages

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Monosodium urate crystal-induced pro-interleukin-1β production is post-transcriptionally regulated via the p38 signaling pathway in human monocytes

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Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals

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Benefit–Risk Assessment of Diacerein in the Treatment of Osteoarthritis

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Anti-Hyperuricemic and Nephroprotective Effects of Rhein in Hyperuricemic Mice

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Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?

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Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells

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Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages

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Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug–drug interaction in rats

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The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination

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Predicting new molecular targets for rhein using network pharmacology

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A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

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Uric acid as a danger signal in gout and its comorbidities

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Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro

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The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

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Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production

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Rhein lysinate inhibits cell growth by modulating various mitogen-activated protein kinases in cervical cancer cells

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The Inflammasomes: Guardians of the Body

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Monosodium urate crystals in inflammation and immunity

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Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome

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Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages

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Rhein inhibits invasion and migration of human nasopharyngeal carcinoma cells in vitro by down-regulation of matrix metalloproteinases-9 and vascular endothelial growth factor

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Primer: inflammasomes and interleukin 1β in inflammatory disorders

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