Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development

Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield

(2023) Daniel Wrapp et al.   JOURNAL OF VIROLOGY

A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies

(2023) Frederic Bibollet-Ruche et al.   mBio

Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles

(2023) Hanh T. Nguyen et al.   JOURNAL OF VIROLOGY

Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization

(2023) Mallika Sastry et al.   JOURNAL OF VIROLOGY

Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage

(2023) Rory Henderson et al.   Nature Communications

Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles

(2023) Kunyu Wang et al.   Communications Biology

Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions

(2023) Tom G. Caniels et al.   Cell Reports Medicine

Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2

(2022) Evan M. Cale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycans in HIV-1 vaccine design – engaging the shield

(2022) Lachlan P. Deimel et al.   TRENDS IN MICROBIOLOGY

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice

(2022) Zekun Mu et al.   Cell Reports

B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates

(2022) Md. Alamgir Hossain et al.   Cell Reports

Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

(2022) Eleonora Melzi et al.   IMMUNITY

Long-primed germinal centres with enduring affinity maturation and clonal migration

(2022) Jeong Hyun Lee et al.   NATURE

Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection

(2022) Kevin O. Saunders et al.   Science Translational Medicine

Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors

(2022) Sai Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination induces HIV broadly neutralizing antibody precursors in humans

(2022) David J. Leggat et al.   SCIENCE

Virus vaccines: proteins prefer prolines

(2021) Rogier W. Sanders et al.   Cell Host & Microbe

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

(2021) Lawrence Corey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120–MF59 in Adults

(2021) Glenda E. Gray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

(2021) Mohamad-Gabriel Alameh et al.   IMMUNITY

Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials

(2021) Jill Whitley et al.   Translational Research

Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth

(2020) Krishna M. Roskin et al.   NATURE IMMUNOLOGY

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

(2020) Rory Henderson et al.   Nature Communications

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

(2020) Prabhu S. Arunachalam et al.   NATURE MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

(2020) Ryan S. Roark et al.   SCIENCE

Exploitation of glycosylation in enveloped virus pathobiology

(2019) Yasunori Watanabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein and Glycan Mimicry in HIV Vaccine Design

(2019) Gemma E. Seabright et al.   JOURNAL OF MOLECULAR BIOLOGY

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

(2019) Maolin Lu et al.   NATURE

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

(2019) Raiees Andrabi et al.   Cell Reports

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

(2019) Christine A. Bricault et al.   Cell Host & Microbe

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

(2019) Celia C. LaBranche et al.   PLoS Pathogens

Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5

(2019) Joel Finney et al.   JOURNAL OF IMMUNOLOGY

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

(2019) Kevin O. Saunders et al.   SCIENCE

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

(2018) Kevin Wiehe et al.   Cell Host & Microbe

RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses

(2018) Todd Bradley et al.   CELL

Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies

(2018) Alba Torrents de la Peña et al.   Retrovirology

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

(2018) Matthias G. Pauthner et al.   IMMUNITY

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

Polyvalent vaccine approaches to combat HIV-1 diversity

(2017) Bette Korber et al.   IMMUNOLOGICAL REVIEWS

Germline-targeting immunogens

(2017) Leonidas Stamatatos et al.   IMMUNOLOGICAL REVIEWS

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

(2017) Gwo-Yu Chuang et al.   JOURNAL OF VIROLOGY

Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

(2017) Qingbo Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

What Are the Most Powerful Immunogen Design Vaccine Strategies?

(2017) Dennis R. Burton   Cold Spring Harbor Perspectives in Biology

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations

(2017) Wilton B. Williams et al.   Nature Communications

Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

(2017) Qingbo Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

(2016) Ruijun Zhang et al.   Science Translational Medicine

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas

(2015) Hannah J. Barbian et al.   mBio

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies

(2013) Guang Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of HIV-1 Broad Neutralizing Antibodies in 2F5 Knock-in Mice: Selection against Membrane Proximal External Region-Associated Autoreactivity Limits T-Dependent Responses

(2013) L. Verkoczy et al.   JOURNAL OF IMMUNOLOGY

Common Tolerance Mechanisms, but Distinct Cross-Reactivities Associated with gp41 and Lipids, Limit Production of HIV-1 Broad Neutralizing Antibodies 2F5 and 4E10

(2013) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41

(2011) S. Moses Dennison et al.   PLoS One

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Is developing an HIV-1 vaccine possible?

(2010) Barton F Haynes et al.   Current Opinion in HIV and AIDS

Stable Docking of Neutralizing Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Monoclonal Antibodies 2F5 and 4E10 Is Dependent on the Membrane Immersion Depth of Their Epitope Regions

(2009) S. M. Dennison et al.   JOURNAL OF VIROLOGY

Role of HIV membrane in neutralization by two broadly neutralizing antibodies

(2009) S. M. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Hides an Achilles' Heel in Virion Lipids

(2008) Barton F. Haynes et al.   IMMUNITY