Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing
出版年份 2023 全文链接
标题
Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing
作者
关键词
-
出版物
Nature Communications
Volume 14, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-08-25
DOI
10.1038/s41467-023-40901-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
- (2022) Ida Höijer et al. Nature Communications
- Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells
- (2022) M. Kyle Cromer et al. Nature Communications
- Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
- (2021) Mitchell L. Leibowitz et al. NATURE GENETICS
- Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells
- (2021) Bo Wang et al. Nature Biomedical Engineering
- In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation
- (2021) Kuo-Hsuan Chang et al. Stem Cell Research & Therapy
- Application of full-genome analysis to diagnose rare monogenic disorders
- (2021) Joseph T. Shieh et al. npj Genomic Medicine
- Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
- (2021) Huimin Zhang et al. Molecular Cancer
- Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
- (2021) Stamatis Papathanasiou et al. Nature Communications
- Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges
- (2020) Shinya Yamanaka Cell Stem Cell
- B3GALT5 knockout alters gycosphingolipid profile and facilitates transition to human naïve pluripotency
- (2020) Ruey-Jen Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos
- (2020) Michael V. Zuccaro et al. CELL
- CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
- (2019) Grégoire Cullot et al. Nature Communications
- Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients
- (2019) Tobias Deuse et al. NATURE BIOTECHNOLOGY
- Creating cell and animal models of human disease by genome editing using CRISPR/Cas9
- (2019) Ali Zarei et al. JOURNAL OF GENE MEDICINE
- Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
- (2019) Huaigeng Xu et al. Cell Stem Cell
- HumCFS: a database of fragile sites in human chromosomes
- (2019) Rajesh Kumar et al. BMC GENOMICS
- Stem Cells in the Treatment of Disease
- (2019) Helen M. Blau et al. NEW ENGLAND JOURNAL OF MEDICINE
- Generation of hypoimmunogenic human pluripotent stem cells
- (2019) Xiao Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multi-platform discovery of haplotype-resolved structural variation in human genomes
- (2019) Mark J. P. Chaisson et al. Nature Communications
- Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
- (2018) Michael Kosicki et al. NATURE BIOTECHNOLOGY
- Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
- (2018) Jennifer Listgarten et al. Nature Biomedical Engineering
- Defining CRISPR–Cas9 genome-wide nuclease activities with CIRCLE-seq
- (2018) Cicera R. Lazzarotto et al. Nature Protocols
- Refining strategies to translate genome editing to the clinic
- (2017) Tatjana I Cornu et al. NATURE MEDICINE
- CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
- (2017) Shengdar Q Tsai et al. NATURE METHODS
- Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
- (2017) Michiko Mandai et al. NEW ENGLAND JOURNAL OF MEDICINE
- Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
- (2017) NEW ENGLAND JOURNAL OF MEDICINE
- A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action
- (2017) Shiran Abadi et al. PLoS Computational Biology
- Repair Pathway Choices and Consequences at the Double-Strand Break
- (2016) Raphael Ceccaldi et al. TRENDS IN CELL BIOLOGY
- Rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology
- (2015) Hongzhi Cao et al. GigaScience
- Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
- (2014) S. Bae et al. BIOINFORMATICS
- Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
- (2013) Seung Woo Cho et al. NATURE BIOTECHNOLOGY
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- RNA-programmed genome editing in human cells
- (2013) Martin Jinek et al. eLife
- Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
- (2012) H. Thorvaldsdottir et al. BRIEFINGS IN BIOINFORMATICS
- Myrip Couples the Capture of Secretory Granules by the Actin-Rich Cell Cortex and Their Attachment to the Plasma Membrane
- (2012) S. Huet et al. JOURNAL OF NEUROSCIENCE
- Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly
- (2012) Ernest T Lam et al. NATURE BIOTECHNOLOGY
- Integrative genomics viewer
- (2011) James T Robinson et al. NATURE BIOTECHNOLOGY
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