Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells
出版年份 2022 全文链接
标题
Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-08-11
DOI
10.1038/s41467-022-32233-z
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus
- (2021) Sriram Vaidyanathan et al. MOLECULAR THERAPY
- Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
- (2021) Mitchell L. Leibowitz et al. NATURE GENETICS
- Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells
- (2021) M. Kyle Cromer et al. NATURE MEDICINE
- CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
- (2021) J. Boutin et al. Nature Communications
- CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
- (2021) Emmanouela Tsagkaraki et al. Nature Communications
- The mutational constraint spectrum quantified from variation in 141,456 humans
- (2020) Konrad J. Karczewski et al. NATURE
- Gene-editing pipeline takes off
- (2020) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity
- (2020) Cicera R. Lazzarotto et al. NATURE BIOTECHNOLOGY
- Cancer immunotherapy comes of age and looks for maturity
- (2020) Amanda Finck et al. Nature Communications
- CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
- (2019) Grégoire Cullot et al. Nature Communications
- Highly efficient therapeutic gene editing of human hematopoietic stem cells
- (2019) Yuxuan Wu et al. NATURE MEDICINE
- Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I
- (2019) Natalia Gomez-Ospina et al. Nature Communications
- Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34 + Hematopoietic Stem and Progenitor Cells
- (2018) M. Kyle Cromer et al. MOLECULAR THERAPY
- p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
- (2018) Robert J. Ihry et al. NATURE MEDICINE
- CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
- (2018) Emma Haapaniemi et al. NATURE MEDICINE
- CRISPR/Cas9 genome editing in human hematopoietic stem cells
- (2018) Rasmus O Bak et al. Nature Protocols
- Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting
- (2018) Carsten T. Charlesworth et al. Molecular Therapy-Nucleic Acids
- A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
- (2018) Christopher A. Vakulskas et al. NATURE MEDICINE
- Deep intronic mutations and human disease
- (2017) Rita Vaz-Drago et al. HUMAN GENETICS
- Mapping the genomic landscape of CRISPR–Cas9 cleavage
- (2017) Peter Cameron et al. NATURE METHODS
- CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
- (2017) Shengdar Q Tsai et al. NATURE METHODS
- CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
- (2016) Daniel P. Dever et al. NATURE
- Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia
- (2016) Stefanie Göllner et al. NATURE MEDICINE
- Targeting EZH2 in cancer
- (2016) Kimberly H Kim et al. NATURE MEDICINE
- The presence of extra chromosomes leads to genomic instability
- (2016) Verena Passerini et al. Nature Communications
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
- (2015) Ayal Hendel et al. NATURE BIOTECHNOLOGY
- CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
- (2015) Manuel Stemmer et al. PLoS One
- Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
- (2014) S. Bae et al. BIOINFORMATICS
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Easy quantitative assessment of genome editing by sequence trace decomposition
- (2014) Eva K. Brinkman et al. NUCLEIC ACIDS RESEARCH
- COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites
- (2014) Thomas J Cradick et al. Molecular Therapy-Nucleic Acids
- EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
- (2013) Wendy Béguelin et al. CANCER CELL
- The fractured genome of HeLa cells
- (2013) David Mittelman et al. GENOME BIOLOGY
- Identification of Somatic Mutations in Parathyroid Tumors Using Whole-Exome Sequencing
- (2012) M. Kyle Cromer et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- EZH2 mutational status predicts poor survival in myelofibrosis
- (2011) P. Guglielmelli et al. BLOOD
- RUNX1 and its understudied role in breast cancer
- (2011) Kevin A. Janes CELL CYCLE
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Genetic diagnosis by whole exome capture and massively parallel DNA sequencing
- (2009) Murim Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The tyrosine phosphatase Shp2 (PTPN11) in cancer
- (2008) Gordon Chan et al. CANCER AND METASTASIS REVIEWS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started