FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment

Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

(2022) Zhisheng Xu et al.   Nature Communications

FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics

(2022) Yujing Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand

(2022) Sarah J. Backe et al.   Cell Reports

Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4

(2022) Qiqi Guo et al.   Science Advances

Perivascular Macrophages Regulate Blood Flow Following Tissue Damage

(2021) Evelina Vågesjö et al.   CIRCULATION RESEARCH

AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1

(2021) Liwei Xiao et al.   PLoS Genetics

Contemporary Medical Management of Peripheral Artery Disease

(2021) Marc P. Bonaca et al.   CIRCULATION RESEARCH

Structural basis and regulation of the reductive stress response

(2021) Andrew G. Manford et al.   CELL

Mutations of the gene FNIP1 associated with a syndromic autosomal recessive immunodeficiency with cardiomyopathy and pre‐excitation syndrome

(2020) Tim Niehues et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophages of diverse phenotypes drive vascularization of engineered tissues

(2020) P. L. Graney et al.   Science Advances

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

(2020) Jing Zhang et al.   Cell Metabolism

Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction

(2020) Lin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in Folliculin Interacting Protein 1 deficiency

(2020) Francesco Saettini et al.   BLOOD

A Cellular Mechanism to Detect and Alleviate Reductive Stress

(2020) Andrew G. Manford et al.   CELL

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

(2020) Lena Claesson-Welsh et al.   TRENDS IN MOLECULAR MEDICINE

Antiangiogenic VEGF 165 b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease

(2019) Vijay Chaitanya Ganta et al.   CIRCULATION

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90

(2019) Rebecca A. Sager et al.   Cell Reports

Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation

(2019) Cao Nguyen Duong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell Metabolism

(2018) Guy Eelen et al.   PHYSIOLOGICAL REVIEWS

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity

(2018) Tingting Fu et al.   Cell Reports

Mechanisms of Vascular Aging

(2018) Zoltan Ungvari et al.   CIRCULATION RESEARCH

Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration

(2018) Mark Juhas et al.   Nature Biomedical Engineering

The mTOR Independent Function of Tsc1 and FNIPs

(2018) Rebecca A. Sager et al.   TRENDS IN BIOCHEMICAL SCIENCES

Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit

(2016) Jing Liu et al.   EMBO Molecular Medicine

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle

(2016) Xijun Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation ofFnip1is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity

(2016) Owen M. Siggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

(2016) Mark R. Woodford et al.   Nature Communications

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

(2015) Maike Frye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

(2015) Hisashi Hasumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules

(2015) Chih-Wei Hsu et al.   PLoS One

PGC-1α Induces SPP1 to Activate Macrophages and Orchestrate Functional Angiogenesis in Skeletal Muscle

(2014) Glenn C. Rowe et al.   CIRCULATION RESEARCH

Changes in Diabetes-Related Complications in the United States, 1990–2010

(2014) Edward W. Gregg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy

(2014) Nicholas L. Reyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development

(2014) H. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

(2013) Zhenji Gan et al.   JOURNAL OF CLINICAL INVESTIGATION

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Therapeutic angiogenesis for critical limb ischaemia

(2013) Brian H. Annex   Nature Reviews Cardiology

VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level

(2013) T. Arcondeguy et al.   NUCLEIC ACIDS RESEARCH

Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications

(2013) Jean-Sébastien Silvestre et al.   PHYSIOLOGICAL REVIEWS

The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development

(2012) M. Baba et al.   BLOOD

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

(2012) S. Willenborg et al.   BLOOD

Revascularization of Ischemic Skeletal Muscle by Estrogen-Related Receptor-γ

(2012) Antonios Matsakas et al.   CIRCULATION RESEARCH

Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development

(2012) Heon Park et al.   IMMUNITY

Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

(2012) Hisashi Hasumi et al.   JNCI-Journal of the National Cancer Institute

Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ

(2011) Vihang A. Narkar et al.   Cell Metabolism

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

A Vascular Theory of Aging

(2010) D. G. Le Couteur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia

(2009) Anne Limbourg et al.   Nature Protocols

PGC-1  is coupled to HIF-1 -dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

(2009) K. A. O'Hagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine Model of Hindlimb Ischemia

(2009) Hiroshi Niiyama et al.   Jove-Journal of Visualized Experiments

TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype

(2008) R. C. A. Sainson et al.   BLOOD

The Local Injection of Peritoneal Macrophages Induces Neovascularization in Rat Ischemic Hind Limb Muscles

(2008) Nobuyuki Hirose et al.   CELL TRANSPLANTATION

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols