Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

(2014) Elaine A Dunlop et al.   Autophagy

Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation

(2014) Yukiko Hasumi et al.   HUMAN MOLECULAR GENETICS

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

(2014) Ming Yan et al.   JOURNAL OF CLINICAL INVESTIGATION

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival

(2014) Elite Possik et al.   PLoS Genetics

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

(2013) Joerg Betschinger et al.   CELL

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Folliculin Contributes to VHL Tumor Suppressing Activity in Renal Cancer through Regulation of Autophagy

(2013) Prabhat Bastola et al.   PLoS One

Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations

(2013) Laura A. Laviolette et al.   PLoS One

The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development

(2012) M. Baba et al.   BLOOD

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

(2012) Michael S. Nahorski et al.   HUMAN MOLECULAR GENETICS

Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development

(2012) Heon Park et al.   IMMUNITY

Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

(2012) Hisashi Hasumi et al.   JNCI-Journal of the National Cancer Institute

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

(2012) Doug A. Medvetz et al.   PLoS One

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

(2012) R. K. Nookala et al.   Open Biology

Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

(2012) Dapeng Zhang et al.   Frontiers in Genetics

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

(2011) Jeff A Klomp et al.   BMC Medical Genomics

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

(2011) T P Cash et al.   ONCOGENE

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling

(2010) Seung-Beom Hong et al.   Molecular Cancer

Absence of the Birt–Hogg–Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

(2010) R S Preston et al.   ONCOGENE

Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization

(2010) Seung-Beom Hong et al.   PLoS One

The role of the Birt–Hogg–Dubé protein in mTOR activation and renal tumorigenesis

(2009) T R Hartman et al.   ONCOGENE

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

(2009) Y. Hasumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of a novel folliculin-interacting protein FNIP2

(2008) Hisashi Hasumi et al.   GENE

Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys

(2008) M. Baba et al.   JNCI-Journal of the National Cancer Institute

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

(2008) Y Takagi et al.   ONCOGENE

Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia

(2008) Jindong Chen et al.   PLoS One