Cotranslational sorting and processing of newly synthesized proteins in eukaryotes

Visualization of translation and protein biogenesis at the ER membrane

(2023) Max Gemmer et al.   NATURE

Mechanism of signal-anchor triage during early steps of membrane protein insertion

(2023) Haoxi Wu et al.   MOLECULAR CELL

Molecular basis of the TRAP complex function in ER protein biogenesis

(2023) Mateusz Jaskolowski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural inventory of cotranslational protein folding by the eukaryotic RAC complex

(2023) Miglė Kišonaitė et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NAC controls cotranslational N-terminal methionine excision in eukaryotes

(2023) Martin Gamerdinger et al.   SCIENCE

The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains

(2023) Alexandra G. Knorr et al.   PLOS BIOLOGY

Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative

(2023) Eva Pauwels et al.   Science Advances

Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

(2022) Ahmad Jomaa et al.   SCIENCE

Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase

(2022) Miriam Pasquini et al.   Cell Reports

Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding

(2022) Yan Chen et al.   Nature Communications

Signal Peptide Features Determining the Substrate Specificities of Targeting and Translocation Components in Human ER Protein Import

(2022) Sven Lang et al.   Frontiers in Physiology

Substrate-driven assembly of a translocon for multipass membrane proteins

(2022) Arunkumar Sundaram et al.   NATURE

Mechanism of an intramembrane chaperone for multipass membrane proteins

(2022) Luka Smalinskaitė et al.   NATURE

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

(2021) Samuel Itskanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress

(2021) Chatchai Phoomak et al.   Science Advances

Protein N-myristoylation: functions and mechanisms in control of innate immunity

(2021) Bin Wang et al.   Cellular & Molecular Immunology

Deciphering molecular details of the RAC–ribosome interaction by EPR spectroscopy

(2021) Sandra J. Fries et al.   Scientific Reports

Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage

(2021) A. Manuel Liaci et al.   MOLECULAR CELL

Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle

(2021) Ahmad Jomaa et al.   Cell Reports

Mapping the myristoylome through a complete understanding of protein myristoylation biochemistry

(2021) Carmela Giglione et al.   PROGRESS IN LIPID RESEARCH

Binding Affinity Determines Substrate Specificity and Enables Discovery of Substrates for N-Myristoyltransferases

(2021) Dan Su et al.   ACS Catalysis

N-Terminal Proteoforms in Human Disease

(2020) Annelies Bogaert et al.   TRENDS IN BIOCHEMICAL SCIENCES

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation

(2020) Cyril Dian et al.   Nature Communications

MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

(2020) Klemens Wild et al.   Nature Communications

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

(2020) Tatsiana Kosciuk et al.   Nature Communications

Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution

(2020) Thierry Meinnel et al.   TRENDS IN BIOCHEMICAL SCIENCES

The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb

(2020) Ying Zhang et al.   Nature Communications

Structure of the ER membrane complex, a transmembrane-domain insertase

(2020) Lin Bai et al.   NATURE

An intramembrane chaperone complex facilitates membrane protein biogenesis

(2020) Patrick J. Chitwood et al.   NATURE

Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation

(2020) Sunbin Deng et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB

(2020) Sunbin Deng et al.   eLife

Translocon-Associated Protein Complex (TRAP) is Crucial for Co-Translational Translocation of Pre-Proinsulin

(2020) T. Kriegler et al.   JOURNAL OF MOLECULAR BIOLOGY

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC

(2019) Martin Gamerdinger et al.   MOLECULAR CELL

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT

(2019) Kevin C. Stein et al.   MOLECULAR CELL

Cryo–electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B

(2019) Ana S. Ramírez et al.   SCIENCE

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis

(2019) Xin Li et al.   Science Advances

N-terminal acetylation: an essential protein modification emerges as an important regulator of stress responses

(2018) Eric Linster et al.   JOURNAL OF EXPERIMENTAL BOTANY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern

(2018) Benoit Castrec et al.   Nature Chemical Biology

Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex

(2018) Kan Kobayashi et al.   SCIENCE

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

(2018) Katharina Braunger et al.   SCIENCE

Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK

(2018) Leah Gottlieb et al.   STRUCTURE

Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

(2018) Duy Nguyen et al.   Nature Communications

Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins

(2018) Günter Kramer et al.   Annual Review of Biochemistry

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

Ribosome–NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation

(2018) Alexandra G. Knorr et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Dissecting the molecular organization of the translocon-associated protein complex

(2017) Stefan Pfeffer et al.   Nature Communications

The Protease Ste24 Clears Clogged Translocons

(2016) Tslil Ast et al.   CELL

Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunits

(2016) Kanghyun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

(2016) Marie A. Hanebuth et al.   Nature Communications

Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunits

(2016) Kanghyun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N-terminal protein modifications: Bringing back into play the ribosome

(2015) Carmela Giglione et al.   BIOCHIMIE

N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects

(2015) Sylvia Varland et al.   PROTEOMICS

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

The Molecular Basis for Histone H4- and H2A-Specific Amino-Terminal Acetylation by NatD

(2015) Robert S. Magin et al.   STRUCTURE

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome

(2014) Yixiao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

(2014) Emmanuelle Thinon et al.   Nature Communications

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

The Ribosome as a Hub for Protein Quality Control

(2013) Sebastian Pechmann et al.   MOLECULAR CELL

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum

(2011) Gabriella M. A. Forte et al.   PLOS BIOLOGY

Extent of N-terminal modifications in cytosolic proteins from eukaryotes

(2008) Aude Martinez et al.   PROTEOMICS