Interferon induction by STING requires its translocation to the late endosomes

STING trafficking as a new dimension of immune signaling

(2023) Devon Jeltema et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy

(2023) Wei Wan et al.   EMBO JOURNAL

ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING

(2023) Run Fang et al.   IMMUNITY

STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage

(2023) Chenyao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAM transports STING oligomers into extracellular vesicles, down‐regulating the innate immune response

(2023) Jiaqi Liang et al.   Journal of Extracellular Vesicles

Clathrin-associated AP-1 controls termination of STING signalling

(2022) Ying Liu et al.   NATURE

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

(2021) Ting-Ting Chu et al.   NATURE

STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk

(2021) Chenyao Wang et al.   mBio

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

(2020) Vladislav Pokatayev et al.   NATURE IMMUNOLOGY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STEEP mediates STING ER exit and activation of signaling

(2020) Bao-cun Zhang et al.   NATURE IMMUNOLOGY

EGFR ‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions

(2020) Chenyao Wang et al.   EMBO JOURNAL

STIM1 moonlights as an anchor for STING

(2019) Jianjun Wu et al.   NATURE IMMUNOLOGY

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection

(2019) Markus Stempel et al.   EMBO JOURNAL

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

(2018) Gustavo P. Amarante-Mendes et al.   Frontiers in Immunology

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

The Emerging Roles of STING in Bacterial Infections

(2017) Fabio V. Marinho et al.   TRENDS IN MICROBIOLOGY

Ubiquitin signaling in immune responses

(2016) Hongbo Hu et al.   CELL RESEARCH

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

Tyrosine phosphorylation in Toll-like receptor signaling

(2014) Saurabh Chattopadhyay et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The cGAS-STING Pathway for DNA Sensing

(2013) T. Sam Xiao et al.   MOLECULAR CELL

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY