Article
Plant Sciences
Ye Yuan, Yuye Liu, Shuangjiang Chen, Lili Wang, Lixin Wang, Yahong Niu, Xin Zhao, Zhihui Zhao, Zhiguo Liu, Mengjun Liu
Summary: A protein called PbrTTM1 was identified as having AC activity in pear. It can complement AC deficiencies in E. coli and has a closed tunnel structure with charged residues possibly involved in catalysis. Its AC activity seems to be a moonlighting function compared to its hydrolysis activity.
FRONTIERS IN PLANT SCIENCE
(2023)
Editorial Material
Cell Biology
Scott A. Gerber, Arminja N. Kettenbach
Summary: A recent study reveals that the metabolic phosphatase fructose-1,6-bisphosphatase 1 (FBP1) can function as a nuclear protein phosphatase and explains its inhibition mechanism in cancer cells.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bhaba Krishna Das, Wajahat Ali Khan, Sreeshma Nellootil Sreekumar, Kannapiran Ponraj, V. Mohan Murali Achary, Elluri Seetharami Reddy, D. Balasubramaniam, Anmol Chandele, Malireddy K. Reddy, Arulandu Arockiasamy
Summary: Plant dehydroascorbate reductases (DHARs) are soluble antioxidant enzymes that protect plants from oxidative stress. Our study reveals the existence of a novel membrane-integrated form of DHAR in plants, which can also conduct ions and is translocated to the plasma membrane under induced oxidative stress.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Tim Crul, Jozsef Maleth
Summary: The article discusses the ultimate specificity in activation and action in eukaryotic cells, as well as the essential role of second messengers in regulating cellular functions. It highlights the importance of segregating molecules to specific plasma membrane subdomains and dynamic contacts between intracellular organelles for cell signaling regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jin Seok Woo, Sun-Hee Hwang, SeungCheon Yang, Kun Hee Lee, Yeon Su Lee, Jeong Won Choi, Jin-Sil Park, JooYeon Jhun, Sung-Hwan Park, Mi-La Cho
Summary: This study investigated the effects of Lactobacillus acidophilus and propionate on the development and progression of Sjogren's syndrome (SS) in a mouse model. It was found that L. acidophilus and propionate could ameliorate SS symptoms by inhibiting the STIM1-STING signaling pathway, suggesting their therapeutic potential for SS.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Mingtong Ma, Yifang Dang, Boran Chang, Fei Wang, Junfang Xu, Li Chen, Hang Su, Jinsong Li, Baoxue Ge, Chang Chen, Haipeng Liu
Summary: In this study, the researchers identified the mechanism underlying the regulation of STING exit from the endoplasmic reticulum. They found that activated TAK1 directly mediates STING phosphorylation, promoting its oligomerization and translocation for subsequent activation. This finding has important implications for tumor immunotherapy and intervention in STING-related diseases.
Article
Virology
Feifei Diao, Juan Bai, Chenlong Jiang, Yangyang Sun, Yanni Gao, Hans Nauwynck, Ping Jiang, Xing Liu
Summary: This study reveals that stimulator of interferon genes (STING) suppresses the replication of porcine reproductive and respiratory syndrome virus (PRRSV) through type I interferon signaling. However, PRRSV can inhibit STING function by impeding its translocation. Moreover, the nonstructural protein 2 (Nsp2) of PRRSV interacts with STING and disrupts its function. Additionally, PRRSV Nsp2 retains STING at the endoplasmic reticulum by increasing the level of STIM1 protein.
JOURNAL OF VIROLOGY
(2023)
Article
Biology
Robert A. Crawford, Mark P. Ashe, Simon J. Hubbard, Graham D. Pavitt
Summary: Translation regulation is an important cellular response to changing external conditions. This study identified RNA-binding proteins (RBPs) involved in translational control using polysome profiling and mass spectrometry. The results revealed previously under-appreciated RBPs and their roles in response to oxidative stress and amino acid starvation.
Review
Multidisciplinary Sciences
Xiangjun Kong, Huali Zuo, Hsien-Da Huang, Qianru Zhang, Jiayu Chen, Chengwei He, Yuanjia Hu
Summary: This article aims to summarize the current situation, development trends, and emerging technologies in the field of STING modulation. Through the analysis of clinical-stage drugs and global patent status, it is found that research and development on STING are increasing, but the current STING agonists have shown limited anti-tumor efficacy in clinical trials.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Oncology
Afsaneh Amouzegar, Manoj Chelvanambi, Jessica N. Filderman, Walter J. Storkus, Jason J. Luke
Summary: Immunotherapies have significantly impacted cancer treatment, yet some patients do not respond effectively. Recent efforts have been focused on identifying targets that could enhance anti-tumor immune responses, with STING pathway being one novel and promising target. Research on STING agonists has opened avenues for developing more effective strategies in cancer immunotherapy.
Article
Economics
Fengxian Chen, Tianruo Hao
Summary: This paper presents an alternative method to estimate the degree of RMB internationalization by combining the modified Frankel-Wei's weight-inference technique and the state space model. Using a large sample of monthly exchange rate data of 54 economies, the authors estimate the dynamic currency weights of major currencies, including the RMB. The results show fluctuations in the RMB's international anchor currency status and identify the key drivers promoting the weight of the RMB. These findings contribute to the literature and provide valuable insights into the dynamics of currency weights.
Article
Veterinary Sciences
Jia Wang, Yao Li, Longji Pan, Jun Li, Yanfei Yu, Beibei Liu, Muhammad Zubair, Yanna Wei, Bala Pillay, Ademola Olufolahan Olaniran, Thamsanqa E. Chiliza, Guoqing Shao, Zhixin Feng, Qiyan Xiong
Summary: Mycoplasma hyorhinis infects pigs and humans, with its surface GAPDH acting as an important adhesion factor and a receptor for binding plasminogen, facilitating the degradation of extracellular matrix and systemic invasion.
VETERINARY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Annalaura Paulis, Enzo Tramontano
Summary: Invading pathogens weaken the host by subverting physiological conditions, while cells have developed countermeasures to maintain cellular physiology and counteract pathogenesis. The cGAS-STING pathway plays a crucial role in innate immunity activation by recognizing viral DNA and producing IFN-I. Targeting STING has the potential for developing broad-spectrum antivirals, and this review explores the function of STING, its modulation, viral evasion mechanisms, and therapeutic strategies to restore its functionality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Leonard Barasa, Sauradip Chaudhuri, Jeffrey Y. Zhou, Zhaozhao Jiang, Shruti Choudhary, Robert Madison Green, Elenore Wiggin, Michael Cameron, Fiachra Humphries, Katherine A. Fitzgerald, Paul R. Thompson
Summary: The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is crucial for detecting cytosolic dsDNA and triggering inflammatory response. Aberrant STING activation is associated with diseases such as ALS, lupus, AGS, and SAVI. In this study, we developed LB244 as a highly potent and selective inhibitor of STING signaling, which showed efficacy comparable to BB-Cl-amidine in vivo. These findings suggest a potential therapeutic approach for STING-dependent inflammatory diseases.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Wei Wan, Chuying Qian, Qian Wang, Jin Li, Hongtao Zhang, Lei Wang, Maomao Pu, Yewei Huang, Zhengfu He, Tianhua Zhou, Han-Ming Shen, Wei Liu
Summary: The cGAS-STING pathway plays a crucial role in host defense by sensing pathogen DNA and inducing immune responses. In this study, it was discovered that STING directly interacts with WIPI2, a key protein involved in autophagy. This interaction is necessary for the formation of autophagosomes induced by STING, but does not affect the activation and trafficking of STING. Furthermore, the specific interaction between STING and WIPI2 leads to competition with PI3P binding, resulting in mutual inhibition between STING-induced autophagy and canonical PI3P-dependent autophagy.
Editorial Material
Immunology
Jianjun Wu, Nan Yan
Summary: A recent study identified an innate-like cytosolic DNA-sensing mechanism in aged CD4(+) T cells, driven by the KU complex, which exacerbates aging-related autoimmunity.
Article
Multidisciplinary Sciences
Ting-Ting Chu, Xintao Tu, Kun Yang, Jianjun Wu, Joyce J. Repa, Nan Yan
Summary: This study identifies a cGAS- and cGAMP-independent mode of STING activation that affects neuropathology and provides a therapeutic target for the treatment of Niemann-Pick disease type C.
Article
Immunology
Rajkumar Venkatadri, Vikram Sabapathy, Murat Dogan, Saleh Mohammad, Scott E. Harvey, Sean R. Simpson, Jason M. Grayson, Nan Yan, Fred W. Perrino, Rahul Sharma
Summary: The study reveals a Th1 bias and elevated Tfh cells and germinal center B cells in TREX1 D18N mice. Inhibiting Bcl6 can attenuate Tfh, germinal center, and Th1 responses and rescue TREX1 D18N mice from autoimmunity. These findings suggest that Tfh cells and germinal center B cells may serve as potential therapeutic targets for autoimmune diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Taisuke Ohto, Ahmed Abu Tayeh, Ryuta Nishikomori, Hiroto Abe, Kyota Hashimoto, Shiro Baba, Anahi-Paula Arias-Loza, Nobumasa Soda, Saya Satoh, Masashi Matsuda, Yusuke Iizuka, Takashi Kondo, Haruhiko Koseki, Nan Yan, Takahiro Higuchi, Takashi Fujita, Hiroki Kato
Summary: Mutations in the IFIH1 gene, which codes for the viral RNA sensor MDA5, have been found to be responsible for the development of myocarditis and nephritis. This study demonstrates that the production of type I interferons and chemokines from cardiomyocytes play a critical role in the development of myocarditis. Activated lymphocytes and autoantibodies exacerbate the pathogenesis but are not necessary for the onset of the disease.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Jianjun Wu, Nan Yan
Summary: This review article summarizes the important role of stimulator of interferon genes (STING) in infection, autoimmune disease, and cancer. It focuses on the evolutionary origin and molecular mechanisms of STING-mediated interferon-independent activities. The article highlights that STING not only produces interferons, but also functions as a hub that converts multiple environmental cues into diverse cellular responses. These findings provide new insights for the clinical testing of STING agonists in cancer and the treatment of STING-associated human diseases.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Immunology
Kun Yang, Jie Han, Jennifer G. Gill, Jason Y. Park, Meghana N. Sathe, Jyothsna Gattineni, Tracey Wright, Christian Wysocki, M. Teresa de la Morena, Nan Yan
Summary: Mutations in the SKIV2L gene cause severe B cell immunodeficiency in THES patients, indicating its crucial role in early B cell development.
SCIENCE IMMUNOLOGY
(2022)
Review
Immunology
Devon Jeltema, Kennady Abbott, Nan Yan
Summary: STING signaling plays a central role in multiple autoinflammatory and neurodegenerative diseases. This study reviews the influence of STING trafficking on signaling, proposes a model of tonic STING signaling, and discusses the emerging link between dysregulated STING trafficking and neurodegenerative disease.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Francine Lianne Emralino, Saya Satoh, Nobuhiro Sakai, Masamichi Takami, Fumihiko Takeuchi, Nan Yan, Frank Rutsch, Takashi Fujita, Hiroki Kato
Summary: Gain-of-function mutations in MDA5 lead to autoimmune IFNopathies. Mice with the SMS-associated mutation R822Q develop SMS-like symptoms and uncontrollable inflammation upon viral infection or vaccination. Interrupting IFN signaling or inhibiting JAK signaling can alleviate inflammation and improve mucosal damage, enabling survival.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xintao Tu, Ting-Ting Chu, Devon Jeltema, Kennady Abbott, Kun Yang, Cong Xing, Jie Han, Nicole Dobbs, Nan Yan
Summary: This study reveals that interference with STING trafficking can trigger basal activation of interferon signaling, providing protection against infection. GCC2 and several RAB GTPases are identified as key regulators during the post-Golgi trafficking of STING. These findings suggest the potential of exploiting this mechanism for cancer immunotherapy.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Kun Yang, Nan Yan
Article
Medicine, Research & Experimental
Kun Yang, Jie Han, Mayumi Asada, Jennifer G. Gill, Jason Y. Park, Meghana N. Sathe, Jyothsna Gattineni, Tracey Wright, Christian A. Wysocki, M. Teresa de la Morena, Luis A. Garza, Nan Yan
Summary: Inborn errors of nucleic acid metabolism often cause aberrant activation of nucleic acid sensing pathways, leading to autoimmune or autoinflammatory diseases. This study demonstrates the physiological function of SKIV2L in mammals. Skiv2l deficiency disrupts the homeostasis of epidermis and T cells, resulting in skin inflammation and hair abnormality. SKIV2L loss activates the mTORC1 pathway and drives autoinflammatory disease.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Hideo Onizawa, Hiroki Kato, Hiroyuki Kimura, Tomoo Kudo, Nobumasa Soda, Shota Shimizu, Masahide Funabiki, Yusuke Yagi, Yuji Nakamoto, Josef Priller, Ryuta Nishikomori, Toshio Heike, Nan Yan, Tohru Tsujimura, Tsuneyo Mimori, Takashi Fujita
Summary: MDA5, as a cytoplasmic sensor of viral RNA triggering IFN-I production, has been linked to autoimmune diseases and AGS. Studies on mice with constitutively active MDA5 have revealed typical features of AGS, suggesting that microglia could be a potential target for AGS therapy.
INTERNATIONAL IMMUNOLOGY
(2021)
