The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib

Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline

(2022) Zhen Ren et al.   ARCHIVES OF TOXICOLOGY

The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

(2020) Si Chen et al.   ARCHIVES OF TOXICOLOGY

Factors affecting high-grade hepatotoxicity of tyrosine kinase inhibitors in cancer patients: a multi-center observational study

(2020) Ji Min Han et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

(2020) Noëmi Johanna Roos et al.   Frontiers in Pharmacology

In vitro assessment of the photo(geno)toxicity associated with Lapatinib, a Tyrosine Kinase inhibitor

(2020) Guillermo García-Lainez et al.   ARCHIVES OF TOXICOLOGY

Detoxication vs. Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib

(2020) Dasean T. Nardone-White et al.   DRUG METABOLISM AND DISPOSITION

DNA Damage and Perturbed Topoisomerase IIα as a Target of 1,4-Benzoquinone Toxicity in Murine Fetal Liver Cells

(2019) Trent H Holmes et al.   TOXICOLOGICAL SCIENCES

HLA-DRB1*07:01 and lapatinib-induced hepatotoxicity: a systematic review and meta-analysis

(2019) Wimonchat Tangamornsuksan et al.   PHARMACOGENOMICS JOURNAL

The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone

(2018) Si Chen et al.   ARCHIVES OF TOXICOLOGY

DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells

(2018) Si Chen et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

(2017) Franziska Paech et al.   Frontiers in Pharmacology

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

(2016) Jiekun Xuan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity

(2016) Qiangen Wu et al.   TOXICOLOGY LETTERS

TAMH: A Useful In Vitro Model for Assessing Hepatotoxic Mechanisms

(2016) Madison Davis et al.   Biomed Research International

Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib

(2015) Han Kiat Ho et al.   DRUG METABOLISM REVIEWS

Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01

(2015) L R Parham et al.   PHARMACOGENOMICS JOURNAL

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

(2015) Zhuhong Zhang et al.   Scientific Reports

The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01

(2015) Makoto Hirasawa et al.   PLoS One

Hepatotoxicity of Tyrosine Kinase Inhibitors: Clinical and Regulatory Perspectives

(2013) Rashmi R. Shah et al.   DRUG SAFETY

Pattern of Rash, Diarrhea, and Hepatic Toxicities Secondary to Lapatinib and Their Association With Age and Response to Neoadjuvant Therapy: Analysis From the NeoALTTO Trial

(2013) Hatem A. Azim et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanism study of goldenseal-associated DNA damage

(2013) Si Chen et al.   TOXICOLOGY LETTERS

Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence

(2012) Yi Ling Teo et al.   BREAST CANCER RESEARCH AND TREATMENT

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib

(2010) W. C. Teng et al.   MOLECULAR PHARMACOLOGY