Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01

Prospective Validation ofHLA-DRB1*07:01Allele Carriage As a Predictive Risk Factor for Lapatinib-Induced Liver Injury

(2014) Daniel J. Schaid et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications

(2014) Andy Rimmer et al.   NATURE GENETICS

HIBAG—HLA genotype imputation with attribute bagging

(2013) X Zheng et al.   PHARMACOGENOMICS JOURNAL

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

Lapatinib-Induced Liver Injury Characterized by Class II HLA and Gilbert's Syndrome Genotypes

(2012) C F Spraggs et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial

(2012) Paul E Goss et al.   LANCET ONCOLOGY

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Pharmacogenetics at 50: Genomic Personalization Comes of Age

(2012) T. J. Urban et al.   Science Translational Medicine

Drug Hypersensitivity and Human Leukocyte Antigens of the Major Histocompatibility Complex

(2011) Mandvi Bharadwaj et al.   Annual Review of Pharmacology and Toxicology

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan

(2011) Pei Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor

(2010) William McLaren et al.   BIOINFORMATICS

Stampy: A statistical algorithm for sensitive and fast mapping of Illumina sequence reads

(2010) G. Lunter et al.   GENOME RESEARCH

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Pharmacogenetics of drug hypersensitivity

(2010) Elizabeth J Phillips et al.   PHARMACOGENOMICS

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

(2008) Diana Chessman et al.   IMMUNITY

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

The IMGT/HLA database

(2008) J. Robinson et al.   NUCLEIC ACIDS RESEARCH