DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells

Modulation of Amyloid-β Peptide-Induced Toxicity through Inhibition of JNK Nuclear Localization and Caspase-2 Activation

(2017) Ricardo J.S. Viana et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

(2016) Si Chen et al.   ARCHIVES OF TOXICOLOGY

Mechanism of caspase-2 activation upon DNA damage

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Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells

(2015) Xiaoqing Guo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells

(2015) Chun-Chi Wu et al.   PLoS One

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Endoplasmic Reticulum Stress-Mediated Activation of p38 MAPK, Caspase-2 and Caspase-8 Leads to Abrin-Induced Apoptosis

(2014) Ritu Mishra et al.   PLoS One

The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells

(2014) Si Chen et al.   TOXICOLOGICAL SCIENCES

Hepatic toxicity of dronedarone in mice: Role of mitochondrial β-oxidation

(2014) Andrea Felser et al.   TOXICOLOGY

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

(2013) Mallikarjun Patil et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway

(2013) Si Chen et al.   TOXICOLOGICAL SCIENCES

Utilization of Causal Reasoning of Hepatic Gene Expression in Rats to Identify Molecular Pathways of Idiosyncratic Drug-Induced Liver Injury

(2013) Daphna Laifenfeld et al.   TOXICOLOGICAL SCIENCES

Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells

(2013) Kathy C. Nguyen et al.   TOXICOLOGY

Involvement of enniatins-induced cytotoxicity in human HepG2 cells

(2013) Ana Juan-García et al.   TOXICOLOGY LETTERS

Mechanism study of goldenseal-associated DNA damage

(2013) Si Chen et al.   TOXICOLOGY LETTERS

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

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Drug safety evaluation of dronedarone in atrial fibrillation

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Mechanisms of Hepatocellular Toxicity Associated with Dronedarone—A Comparison to Amiodarone

(2012) Andrea Felser et al.   TOXICOLOGICAL SCIENCES

Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria

(2012) Mathieu Porceddu et al.   TOXICOLOGICAL SCIENCES

Acute Liver Failure Associated With Dronedarone

(2011) Nader Joghetaei et al.   Circulation-Arrhythmia and Electrophysiology

Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration

(2011) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

(2010) L. Guo et al.   DRUG METABOLISM AND DISPOSITION

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

The unpredictable caspase-2: what can it do?

(2010) Helin Vakifahmetoglu-Norberg et al.   TRENDS IN CELL BIOLOGY

Dronedarone

(2009) Chinmay Patel et al.   CIRCULATION

Dronedarone

(2009) Sheridan M. Hoy et al.   DRUGS

Structure and Activation Mechanism of the CHK2 DNA Damage Checkpoint Kinase

(2009) Zhenjian Cai et al.   MOLECULAR CELL

Cell based approaches for evaluation of drug-induced liver injury

(2009) Mhairi L. Greer et al.   TOXICOLOGY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY