Shifting the trajectory of therapeutic development for neurological and psychiatric disorders

The foundation and architecture of precision medicine in neurology and psychiatry

(2023) Harald Hampel et al.   TRENDS IN NEUROSCIENCES

Predicting amyloid PET and tau PET stages with plasma biomarkers

(2023) Clifford R Jack et al.   BRAIN

Neurofilament light‐chain response during therapy with antisense oligonucleotide tofersen in SOD1‐related ALS: Treatment experience in clinical practice

(2023) Thomas Meyer et al.   MUSCLE & NERVE

Autism genes converge on asynchronous development of shared neuron classes

(2022) Bruna Paulsen et al.   NATURE

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

(2022) Emily G. Baxi et al.   NATURE NEUROSCIENCE

Rare coding variants in ten genes confer substantial risk for schizophrenia

(2022) Tarjinder Singh et al.   NATURE

An integrated framework for local genetic correlation analysis

(2022) Josefin Werme et al.   NATURE GENETICS

Genetic ancestry in precision medicine is reshaping the race debate

(2022) Talia Krainc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Children with autism spectrum disorder show atypical electroencephalographic response to processing contextual incongruencies

(2022) Amparo V. Márquez-García et al.   Scientific Reports

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

(2022) Nina M. Dräger et al.   NATURE NEUROSCIENCE

Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning

(2022) Nikolaos Koutsouleris et al.   JAMA Psychiatry

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

(2022) Timothy M. Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional regulatory variants implicate distinct transcriptional networks in dementia

(2022) Yonatan A. Cooper et al.   SCIENCE

Current Approaches in Computational Psychiatry for the Data-Driven Identification of Brain-Based Subtypes

(2022) Leyla R. Brucar et al.   BIOLOGICAL PSYCHIATRY

Melanin and Neuromelanin: Linking Skin Pigmentation and Parkinson's Disease

(2022) Talia Krainc et al.   MOVEMENT DISORDERS

Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience

(2021) Helen Rankin Willsey et al.   NEURON

Developing the ATX(N) classification for use across the Alzheimer disease continuum

(2021) Harald Hampel et al.   Nature Reviews Neurology

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease

(2021) Dallas P. Veitch et al.   Alzheimers & Dementia

Neurofilament light chain and C reactive protein explored as predictors of survival in amyotrophic lateral sclerosis

(2020) Maxim De Schaepdryver et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

CRISPR-based functional genomics for neurological disease

(2020) Martin Kampmann   Nature Reviews Neurology

Innovations present in the primate interneuron repertoire

(2020) Fenna M. Krienen et al.   NATURE

Pathophysiological subtypes of Alzheimer’s disease based on cerebrospinal fluid proteomics

(2020) Betty M Tijms et al.   BRAIN

Multimodal Machine Learning Workflows for Prediction of Psychosis in Patients With Clinical High-Risk Syndromes and Recent-Onset Depression

(2020) Nikolaos Koutsouleris et al.   JAMA Psychiatry

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Neurofilaments in pre-symptomatic ALS and the impact of genotype

(2019) Michael Benatar et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

ERP indices of performance monitoring and feedback processing in psychosis: A meta-analysis

(2018) Elizabeth A. Martin et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Accurate classification of BRCA1 variants with saturation genome editing

(2018) Gregory M. Findlay et al.   NATURE

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

(2018) Michael Inouye et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Regulatory watch: Challenges in drug development for central nervous system disorders: a European Medicines Agency perspective

(2016) Florence Butlen-Ducuing et al.   NATURE REVIEWS DRUG DISCOVERY

Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis

(2015) Patrick Weydt et al.   ANNALS OF NEUROLOGY

Two decades of new drug development for central nervous system disorders

(2015) Aaron S. Kesselheim et al.   NATURE REVIEWS DRUG DISCOVERY

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Neuroscience in the era of functional genomics and systems biology

(2009) Daniel H. Geschwind et al.   NATURE